{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:54:08Z","timestamp":1767862448073,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-NS053792"],"award-info":[{"award-number":["R01-NS053792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F31-NS077700"],"award-info":[{"award-number":["F31-NS077700"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Epilepsy Foundation Predoctoral Fellowship"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.eplepsyres.2015.11.016","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T08:30:18Z","timestamp":1448958618000},"page":"20-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations"],"prefix":"10.1016","volume":"119","author":[{"given":"Nicole A.","family":"Hawkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0005","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/epi.12657","article-title":"Antiepileptic activity of preferential inhibitors of persistent sodium current","volume":"55","author":"Anderson","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0010","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00335-005-0049-4","article-title":"Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a","volume":"16","author":"Bergren","year":"2005","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00335-009-9193-6","article-title":"Fine mapping of an epilepsy modifier gene on mouse Chromosome 19","volume":"20","author":"Bergren","year":"2009","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0020","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1101\/gad.301404","article-title":"The loss of circadian PAR bZip transcription factors results in epilepsy","volume":"18","author":"Gachon","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1601-183X.2012.00790.x","article-title":"Confirmation of an epilepsy modifier locus on mouse chromosome 11 and candidate gene analysis by RNA-Seq","volume":"11","author":"Hawkins","year":"2012","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0030","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nbd.2010.11.016","article-title":"Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus","volume":"41","author":"Hawkins","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0167-4838(95)00025-P","article-title":"Pyridoxal phosphate-dependent enzymes","volume":"1248","author":"John","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0040","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1073\/pnas.1017539108","article-title":"Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility","volume":"108","author":"Jorge","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0045","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1172\/JCI66220","article-title":"Sudden unexpected death in a mouse model of Dravet syndrome","volume":"123","author":"Kalume","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0050","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-4522(00)00479-6","article-title":"A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities","volume":"102","author":"Kearney","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0055","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1113\/jphysiol.2010.188482","article-title":"Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects","volume":"588","author":"Meisler","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/gbb.12099","article-title":"Mapping genetic modifiers of survival in a mouse model of Dravet syndrome","volume":"13","author":"Miller","year":"2014","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2014.01.006","article-title":"Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice","volume":"65","author":"Mistry","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"Suppl 2","key":"10.1016\/j.eplepsyres.2015.11.016_bib0070","first-page":"73","article-title":"Vitamin B6 dependent seizures","volume":"36","author":"Plecko","year":"2009","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0075","series-title":"Epilepsy Fact Sheet N\u00b0999","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.eplepsyres.2015.11.016_bib0080","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121115300760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121115300760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:34:12Z","timestamp":1760276052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121115300760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":16,"alternative-id":["S0920121115300760"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2015.11.016","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2015.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}