{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:39:32Z","timestamp":1777329572703,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.eplepsyres.2016.06.012","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T09:08:33Z","timestamp":1467104913000},"page":"16-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment"],"prefix":"10.1016","volume":"126","author":[{"given":"Josy Carolina C.","family":"Pontes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Z.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio M.","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone M.","family":"Cinini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam M.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-1108","authenticated-orcid":false,"given":"Luiz E.","family":"Mello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yebeh.2008.02.010","article-title":"Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset","volume":"13","author":"Bachiega","year":"2008","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0166-4328(99)00153-9","article-title":"Measuring fear and anxiety in the marmoset (Callithrix penicillata) with a novel predator confrontation model: effects of diazepam","volume":"108","author":"Barros","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yebeh.2005.05.014","article-title":"Anxiety in patients with epilepsy: systematic review and suggestions for clinical management","volume":"7","author":"Beyenburg","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrd2997","article-title":"Key factors in the discovery and development of new antiepileptic drugs","volume":"9","author":"Bialer","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0025","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1073\/pnas.94.17.9422","article-title":"A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year","volume":"94","author":"Bing","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0030","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1528-1167.2008.01797.x","article-title":"Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models","volume":"50","author":"Blanco","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0035","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00381-006-0145-0","article-title":"Pre-surgical evaluation and surgical treatment in children with extratemporal epilepsy","volume":"22","author":"Centeno","year":"2006","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0091-3057(96)00376-0","article-title":"Marmoset conspecific confrontation: an ethologically-based model of anxiety","volume":"58","author":"Cilia","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(83)90386-2","article-title":"Modulated anticonvulsant block of sodium channels in nerve and muscle","volume":"88","author":"Courtney","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1098-1063(2000)10:2<169::AID-HIPO6>3.0.CO;2-W","article-title":"Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus","volume":"10","author":"Covolan","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0055","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.eplepsyres.2014.08.005","article-title":"Medication side effects among people with epilepsy taking phenobarbital in Zambia","volume":"108","author":"Elafros","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0065","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1523\/JNEUROSCI.18-17-06952.1998","article-title":"Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures","volume":"18","author":"Hiroi","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0070","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0212s45","article-title":"The importance of titrating antibodies for immunocytochemical methods","author":"Hoffman","year":"2008","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0075","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/jps.23575","article-title":"Quantitative atlas of blood\u2013brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset","volume":"102","author":"Hoshi","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0080","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-3565(24)29466-0","article-title":"Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action","volume":"298","author":"Huang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0085","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0028-3908(00)00009-5","article-title":"Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram","volume":"39","author":"Husum","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0090","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.0013-9580.2004.12704.x","article-title":"Phenobarbital for the treatment of epilepsy in the 21st century: a critical review","volume":"45","author":"Kwan","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0095","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230647","article-title":"Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats","volume":"102","author":"Lemos","year":"1995","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrn1728","article-title":"Drug resistance in brain diseases and the role of drug efflux transporters","volume":"6","author":"Loscher","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0920-1211(02)00063-3","article-title":"New horizons in the development of antiepileptic drugs","volume":"50","author":"Loscher","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0110","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1528-1167.2011.03024.x","article-title":"Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma","volume":"52","author":"Loscher","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0006-8993(85)90634-1","article-title":"Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats","volume":"339","author":"Loscher","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/dev.420240805","article-title":"Anxiety in rhesus monkey infants in relation to interactions with their mother and other social companions","volume":"24","author":"Maestripieri","year":"1991","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0896-6273(01)00253-7","article-title":"When do epileptic seizures really begin?","volume":"30","author":"McKeown","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0135","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1523\/JNEUROSCI.04-09-02410.1984","article-title":"Evidence implicating substantia nigra in regulation of kindled seizure threshold","volume":"4","author":"McNamara","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0140","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","article-title":"Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting","volume":"34","author":"Mello","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0145","first-page":"51","article-title":"Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy","author":"Mello","year":"1992","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0169-328X(00)00112-1","article-title":"Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy","volume":"79","author":"Morris","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0155","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1023\/A:1026004904199","article-title":"The recurrent mossy fiber pathway of the epileptic brain","volume":"28","author":"Nadler","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.eplepsyres.2006.10.003","article-title":"Effect of antiepileptic drugs on spontaneous seizures in epileptic rats","volume":"73","author":"Nissinen","year":"2007","journal-title":"Epilepsy Res."},{"issue":"Suppl. 9","key":"10.1016\/j.eplepsyres.2016.06.012_bib0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1528-1167.2005.00326.x","article-title":"Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies","volume":"46","author":"Patsalos","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eplepsyres.2011.04.015","article-title":"Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate","volume":"96","author":"Perez-Mendes","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0175","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1523\/JNEUROSCI.4056-03.2004","article-title":"Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus","volume":"24","author":"Richichi","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0180","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0091-3057(91)90258-4","article-title":"Measuring anxiety in nonhuman primates: effect of lorazepam on macaque scratching","volume":"38","author":"Schino","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0003-3472(76)80053-X","article-title":"An ethogram of the common marmoset (Calithrix jacchus jacchus): general behavioural repertoire","volume":"24","author":"Stevenson","year":"1976","journal-title":"Anim. Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0190","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yebeh.2016.01.032","article-title":"Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures","volume":"57","author":"Tollner","year":"2016","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0195","doi-asserted-by":"crossref","first-page":"16423","DOI":"10.1523\/JNEUROSCI.2506-11.2011","article-title":"The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance","volume":"31","author":"Tollner","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ana.410250302","article-title":"Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital","volume":"25","author":"Twyman","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0205","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1523\/JNEUROSCI.4970-05.2006","article-title":"Regulation of DeltaFosB stability by phosphorylation","volume":"26","author":"Ulery","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0210","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuroscience.2008.10.059","article-title":"Phosphorylation of DeltaFosB mediates its stability in vivo","volume":"158","author":"Ulery-Reynolds","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.npep.2004.05.004","article-title":"Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?","volume":"38","author":"Vezzani","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0920-1211(98)00061-8","article-title":"Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy","volume":"32","author":"Vreugdenhil","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0225","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1528-1157.1999.tb02034.x","article-title":"Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis","volume":"40","author":"Vreugdenhil","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.06.012_bib0230","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s13311-013-0250-1","article-title":"Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies","volume":"11","author":"White","year":"2014","journal-title":"Neurotherapeutics"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116300985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116300985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:34:52Z","timestamp":1760276092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121116300985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":46,"alternative-id":["S0920121116300985"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.06.012","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}