{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:30:50Z","timestamp":1793050250693,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81471316"],"award-info":[{"award-number":["81471316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.eplepsyres.2016.09.004","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T04:03:11Z","timestamp":1473393791000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy"],"prefix":"10.1016","volume":"127","author":[{"given":"Chun-Hong","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Lei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.eplepsyres.2016.09.004_bib0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3748\/wjg.v20.i1.22","article-title":"Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks","volume":"20","author":"Babeu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0010","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005\u20132009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.eplepsyres.2016.09.004_bib0015","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00228-014-1690-1","article-title":"Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China","volume":"70","author":"Chang","year":"2014","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.eplepsyres.2016.09.004_bib0020","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bcp.2011.12.032","article-title":"Lamotrigine is a substrate for OCT1 in brain endothelial cells","volume":"83","author":"Dickens","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.eplepsyres.2016.09.004_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2011.01.016","article-title":"The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy?","volume":"95","author":"Gulcebi","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/FPC.0b013e3282f974b7","article-title":"Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol","volume":"18","author":"Haenisch","year":"2008","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0035","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11095-007-9254-z","article-title":"Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications","volume":"24","author":"Koepsell","year":"2007","journal-title":"Pharm. Res."},{"issue":"11","key":"10.1016\/j.eplepsyres.2016.09.004_bib0040","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00228-015-1925-9","article-title":"Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7-161C>T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children","volume":"71","author":"Liu","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.eplepsyres.2016.09.004_bib0045","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/FTD.0b013e31826517c6","article-title":"Association between lamotrigine concentrations and ABCB1 polymorphisms in patients with epilepsy","volume":"34","author":"Lovri\u0107","year":"2012","journal-title":"Ther. Drug Monit."},{"issue":"8","key":"10.1016\/j.eplepsyres.2016.09.004_bib0050","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neuropharm.2008.08.032","article-title":"Several major antiepileptic drugs are substrates for human P-glycoprotein","volume":"55","author":"Luna-Tort\u00f3s","year":"2008","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.eplepsyres.2016.09.004_bib0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2217\/pgs.14.186","article-title":"SCN1A, ABCC2 and UGT2B7 gene polymorphisms in association with individualized oxcarbazepine therapy","volume":"16","author":"Ma","year":"2015","journal-title":"Pharmacogenomics"},{"issue":"6","key":"10.1016\/j.eplepsyres.2016.09.004_bib0060","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/cpt.317","article-title":"OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics","volume":"99","author":"Matthaei","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.eplepsyres.2016.09.004_bib0065","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2174\/13816128113199990457","article-title":"Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier","volume":"20","author":"Miller","year":"2014","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.eplepsyres.2016.09.004_bib0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/bcp.12984","article-title":"Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: influence of polymorphism of UDP-glucuronosyltransferases and drug transporters","volume":"82","author":"Milosheska","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0075","doi-asserted-by":"crossref","first-page":"752","DOI":"10.5414\/CPP47752","article-title":"Population pharmacokinetics of lamotrigine in patients with epilepsy","volume":"47","author":"Milovanovic","year":"2009","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.eplepsyres.2016.09.004_bib0080","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acs.molpharmaceut.5b00733","article-title":"The non-metabolized \u03b2-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3","volume":"13","author":"Misaka","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0085","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1528-1167.2007.01471.x","article-title":"Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy","volume":"49","author":"Ohman","year":"2008","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.eplepsyres.2016.09.004_bib0090","first-page":"S48","article-title":"Overview of lamotrigine and the new antiepileptic drugs: the challenge","volume":"12","author":"Pellock","year":"2007","journal-title":"J. Child Neurol."},{"issue":"12","key":"10.1016\/j.eplepsyres.2016.09.004_bib0095","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.0013-9580.2003.22603.x","article-title":"Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2\/MRP2-deficient TR- rats","volume":"44","author":"Potschka","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0100","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1528-1167.2005.10105.x","article-title":"Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations","volume":"46","author":"Reimers","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/FTD.0b013e31817fd4d4","article-title":"Population pharmacokinetics of lamotrigine with data from therapeutic drug monitoring in German and Spanish patients with epilepsy","volume":"30","author":"Rivas","year":"2008","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuropharm.2015.01.015","article-title":"The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)","volume":"93C","author":"Romermann","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0115","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/dmd.106.009340","article-title":"In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction","volume":"34","author":"Rowland","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0120","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.1186176","article-title":"Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding","volume":"328","author":"Schmidt","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0125","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00228-012-1449-5","article-title":"Influence of the UGT2B7-161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients","volume":"69","author":"Singkham","year":"2013","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.eplepsyres.2016.09.004_bib0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pharmthera.2006.07.005","article-title":"Novel anticonvulsant drugs","volume":"113","author":"Stefan","year":"2007","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.eplepsyres.2016.09.004_bib0135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40262-015-0241-y","article-title":"Drug transporters in the central nervous system","volume":"54","author":"Stieger","year":"2015","journal-title":"Clin. Pharmacokinet."},{"issue":"10","key":"10.1016\/j.eplepsyres.2016.09.004_bib0140","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/FPC.0b013e3283498131","article-title":"Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy","volume":"21","author":"Ufer","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"issue":"3","key":"10.1016\/j.eplepsyres.2016.09.004_bib0145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0971-6866.92094","article-title":"Genetic analysis of OCT1 gene polymorphisms in an Indian population","volume":"17","author":"Umamaheswaran","year":"2011","journal-title":"Indian J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.eplepsyres.2016.09.004_bib0150","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/ane.12197","article-title":"Effect of oral contraceptives on lamotrigine levels depends on comedication","volume":"129","author":"Wegner","year":"2014","journal-title":"Acta Neurol. Scand."},{"issue":"8","key":"10.1016\/j.eplepsyres.2016.09.004_bib0155","first-page":"9533","article-title":"Genetic variants of OCT1 influence glycemic response to metformin in Han Chinese patients with type-2 diabetes mellitus in Shanghai","volume":"8","author":"Zhou","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"4","key":"10.1016\/j.eplepsyres.2016.09.004_bib0160","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.dmpk.2015.05.002","article-title":"Polymorphisms of ABCG2, ABCB1 and HNF4\u03b1 are associated with Lamotrigine trough concentrations in epilepsy patients","volume":"30","author":"Zhou","year":"2015","journal-title":"Drug Metab. Pharmacokinet."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:37:10Z","timestamp":1760276230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121116301656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":32,"alternative-id":["S0920121116301656"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.004","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}