{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:05:27Z","timestamp":1766048727954,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.eplepsyres.2016.09.005","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T04:03:11Z","timestamp":1473393791000},"page":"191-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon?"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-7167","authenticated-orcid":false,"given":"Nilesh","family":"Kurwale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanwaljeet","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poodipedi Sarat","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-2007-981448","article-title":"Severe bleeding complications during antiepileptic treatment with valproic acid in children","volume":"38","author":"Cannizzaro","year":"2007","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0010","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0609.1996.tb01387.x","article-title":"Acquired and transient factor X deficiency associated with sodium valproate treatment","volume":"57","author":"Gallais","year":"1996","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0015","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1528-1167.2006.00587.x","article-title":"Valproate-associated coagulopathies are frequent and variable in children","volume":"47","author":"Gerstner","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1528-1157.1999.tb00709.x","article-title":"Valproate treatment and platelet function: the role of arachidonate metabolites","volume":"40","author":"Kis","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0025","first-page":"833","article-title":"Valproate-induced bleeding: report of two cases and review of literature","volume":"42","author":"Kumar","year":"2005","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1034\/j.1600-0404.2003.00149.x","article-title":"Valproate induces reversible factor XIII deficiency with risk of perioperative bleeding","volume":"108","author":"Pohlmann-Eden","year":"2003","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-2008-1080939","article-title":"Quantitative assessment of postoperative blood collection in brain tumor surgery under valproate medication","volume":"69","author":"Psaras","year":"2008","journal-title":"Zentralbl. Neurochir."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0040","first-page":"596","article-title":"Valproate induced bleeding","volume":"26","author":"Raghuveer","year":"1989","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0045","first-page":"e19881","article-title":"Anesthesia for patients with liver disease","volume":"14","author":"Rahimzadeh","year":"2014","journal-title":"Hepatitis Mon."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.2006.00655.x","article-title":"Valproate-induced hyperammonemic encephalopathy","volume":"114","author":"Segura-Bruna","year":"2006","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.0013-9580.2004.28302.x","article-title":"Factor XIII deficiency associated with valproate treatment","volume":"45","author":"Teich","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0028-3886.41990","article-title":"Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: a 10-year experience","volume":"56","author":"Tripathi","year":"2008","journal-title":"Neurol. India"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0065","first-page":"403","article-title":"Factor VII deficiency associated with valproate treatment","volume":"50","author":"Unalp","year":"2008","journal-title":"Pediatr. Int. Off. J. Japan Pediatr. Soc."},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1528-1157.1996.tb00519.x","article-title":"Preoperative valproate administration does not increase blood loss during temporal lobectomy","volume":"37","author":"Ward","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.005_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0887-8994(96)00124-5","article-title":"Perioperative blood loss: the effect of valproate","volume":"15","author":"Winter","year":"1996","journal-title":"Pediatr. Neurol."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:37:13Z","timestamp":1760276233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121116301668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":15,"alternative-id":["S0920121116301668"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.005","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon?","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}