{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:52:45Z","timestamp":1791924765024,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.eplepsyres.2016.09.007","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T11:33:57Z","timestamp":1473420837000},"page":"302-310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-2236","authenticated-orcid":false,"given":"Tohru","family":"Okanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Ueda-Kawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysa","family":"Widjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvester H.","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Rutka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Drake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"O. Carter","family":"Snead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Otsubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0005","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/j.1528-1167.2011.03199.x","article-title":"Focal resection of fast ripples on extra-operative intracranial EEG improves seizure outcome in pediatric epilepsy","volume":"52","author":"Akiyama","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3171\/jns.1997.87.3.0391","article-title":"Surgical management and seizure outcome in patients with tuberous sclerosis","volume":"87","author":"Avellino","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3171\/2009.3.PEDS08459","article-title":"Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex","volume":"4","author":"Benifla","year":"2009","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3171\/2011.1.PEDS10348","article-title":"Bilateral invasive electroencephalography in patients with tuberous sclerosis complex: a path to surgery?","volume":"7","author":"Carlson","year":"2011","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0025","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/08830738050200040901","article-title":"Intractable seizures in tuberous sclerosis complex: from molecular pathogenesis to the rationale for treatment","volume":"20","author":"Curatolo","year":"2005","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0030","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1469-8749.2010.03802.x","article-title":"Intractable epilepsy in tuberous sclerosis: is the tuber removal not enough?","volume":"52","author":"Curatolo","year":"2010","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0035","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.clinph.2016.04.007","article-title":"A single tight MEG cluster may only represent a fragment of type I FCD","volume":"127","author":"El Tahry","year":"2016","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0040","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/2012.1.FOCUS11330","article-title":"Epilepsy surgery in tuberous sclerosis: a review","volume":"32","author":"Evans","year":"2012","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0045","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1227\/NEU.0000000000000875","article-title":"Resective epilepsy surgery for tuberous sclerosis in children: determining predictors of seizure outcomes in a multicenter retrospective cohort study","volume":"77","author":"Fallah","year":"2015","journal-title":"Neurosurgery"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/brain\/awh333","article-title":"Utilization of magnetoencephalography results to obtain favourable outcomes in epilepsy surgery","volume":"128","author":"Fischer","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0055","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00004691-198510000-00002","article-title":"Neuronal generators and the problem of localization in electroencephalography: application of volume conductor theory to electroencephalography","volume":"2","author":"Gloor","year":"1985","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0060","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.51.5.1263","article-title":"Surgical treatment of epilepsy in tuberous sclerosis: strategies and results in 18 patients","volume":"51","author":"Guerreiro","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0065","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1528-1167.2007.01035.x","article-title":"Tuberous sclerosis complex and epilepsy: recent developments and future challenges","volume":"48","author":"Holmes","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0070","doi-asserted-by":"crossref","first-page":"s187","DOI":"10.3171\/jns.2005.102.2.0187","article-title":"Characterizing magnetic spike sources by using magnetoencephalography-guided neuronavigation in epilepsy surgery in pediatric patients","volume":"102","author":"Iida","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0075","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1528-1167.2005.14005.x","article-title":"Characterizing magnetoencephalographic spike sources in children with tuberous sclerosis complex","volume":"46","author":"Iida","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0080","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1528-1167.2007.01486.x","article-title":"Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG-fMRI","volume":"49","author":"Jacobs","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0085","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1528-1167.2006.00511.x","article-title":"Magnetoencephalography in patients with tuberous sclerosis and localization-related epilepsy","volume":"47","author":"Kamimura","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0883073808325659","article-title":"Unusual clinical presentation of tuberless tuberous sclerosis complex","volume":"24","author":"Kaufmann","year":"2009","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1528-1167.2008.01814.x","article-title":"Are cortical tubers epileptogenic?: Evidence from electrocorticography","volume":"50","author":"Major","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0100","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1212\/WNL.0b013e3182768923","article-title":"Intrinsic epileptogenicity of cortical tubers revealed by intracranial EEG monitoring","volume":"79","author":"Mohamed","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.seizure.2014.04.006","article-title":"Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome","volume":"23","author":"Mu","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpsycho.2007.12.008","article-title":"Magnetoencephalography-guided epilepsy surgery for children with intractable focal epilepsy: sickKids experience","volume":"68","author":"Ochi","year":"2008","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0115","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1046\/j.1528-1157.2002.10702.x","article-title":"Epileptic spikes: magnetoencephalography versus simultaneous electrocorticography","volume":"43","author":"Oishi","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0120","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/epi.12761","article-title":"Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex","volume":"55","author":"Okanishi","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0125","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1528-1157.1999.tb05563.x","article-title":"Confirmation of two magnetoencephalographic epileptic foci by invasive monitoring from subdural electrodes in an adolescent with right frontocentral epilepsy","volume":"40","author":"Otsubo","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0130","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1046\/j.1528-1157.2001.16701.x","article-title":"MEG predicts epileptic zone in lesional extrahippocampal epilepsy: 12 pediatric surgery cases","volume":"42","author":"Otsubo","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0387-7604(01)00204-2","article-title":"Surgical treatment of medically refractory epilepsy in childhood","volume":"23","author":"Snead","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","article-title":"Neural networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0145","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.3171\/2013.4.FOCUS1357","article-title":"Correlation between magnetoencephalography-based clusterectomy and postoperative seizure freedom","volume":"34","author":"Vadera","year":"2013","journal-title":"Neurosurg. Focus"},{"issue":"Suppl. 4","key":"10.1016\/j.eplepsyres.2016.09.007_bib0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.0013-9580.2004.04009.x","article-title":"Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone","volume":"45","author":"Weiner","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0155","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.eplepsyres.2010.01.008","article-title":"Diffusion tensor imaging identifies changes in normal-appearing white matter within the epileptogenic zone in tuberous sclerosis complex","volume":"89","author":"Widjaja","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1528-1167.2007.01270.x","article-title":"Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation","volume":"49","author":"Wong","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0165","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1212\/WNL.0b013e3181ce5d9e","article-title":"Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex","volume":"74","author":"Wu","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2016.09.007_bib0170","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/adc.2011.211995","article-title":"The Tuberous Sclerosis 2000 Study: presentation, initial assessments and implications for diagnosis and management","volume":"96","author":"Yates","year":"2011","journal-title":"Arch. Dis. Child."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121116301681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:38:09Z","timestamp":1760276289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121116301681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":34,"alternative-id":["S0920121116301681"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.007","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}