{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:31:08Z","timestamp":1780461068853,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26293252"],"award-info":[{"award-number":["26293252"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26461551"],"award-info":[{"award-number":["26461551"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29-Nanji-Ippan-010"],"award-info":[{"award-number":["H29-Nanji-Ippan-010"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.eplepsyres.2017.07.018","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T16:47:50Z","timestamp":1501778870000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of a third or later antiepileptic drug regimen according to epilepsy syndrome among adult patients"],"prefix":"10.1016","volume":"136","author":[{"given":"Go","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Kanemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0005","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.yebeh.2016.09.017","article-title":"Benign mesial temporal lobe epilepsy: a clinical cohort and literature review","volume":"65","author":"AlQassmi","year":"2016","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","article-title":"Proposal for revised classification of epilepsies and epileptic syndromes","volume":"30","author":"Commission on Classification and Terminology of the International League Against Epilepsy","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0015","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005\u20132009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0020","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1212\/WNL.0000000000000673","article-title":"treatment outcome after failure of a first antiepileptic drug","volume":"83","author":"Bonnett","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0025","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/epi.13406","article-title":"Drug-resistant epilepsy in adults: outcome trajectories after failure of two medications","volume":"57","author":"Choi","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1528-1167.2009.02141.x","article-title":"Early versus late remission in a cohort of patients with newly diagnosed epilepsy","volume":"51","author":"Del Felice","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0035","series-title":"Epilepsies: Diagnosis and Management","author":"NICE","year":"2017"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0040","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/seiz.2000.0432","article-title":"Characteristics of valproic acid resistant juvenile myoclonic epilepsy","volume":"9","author":"Fernando-Dongas","year":"2000","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0045","series-title":"Operational Classification of Seizure Types by the International League Against Epilepsy","author":"Fisher","year":"2017"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/jnnp.70.2.240","article-title":"Clinical factors of drug resistance in juvenile myoclonic epilepsy","volume":"70","author":"Gelisse","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/epi.12074","article-title":"Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes","volume":"54","author":"Glauser","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(06)68182-8","article-title":"Epilepsy in children","volume":"367","author":"Guerrini","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1684\/epd.2016.0822","article-title":"How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery","volume":"18","author":"Hern\u00e1ndez-Ronquillo","year":"2016","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijsu.2015.05.006","article-title":"Outcome of surgery for temporal lobe epilepsy in adults \u2212 a cohort study","volume":"36","author":"Jayalakshmi","year":"2016","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0075","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/jama.2014.17426","article-title":"Resective epilepsy surgery for drug-resistant focal epilepsy: a review","volume":"31","author":"Jobst","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0080","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0085","doi-asserted-by":"crossref","first-page":"e0159464","DOI":"10.1371\/journal.pone.0159464","article-title":"Very long-term outcome of non-surgically treated patients with temporal lobe epilepsy with hippocampal sclerosis: a retrospective study","volume":"11","author":"Kurita","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0090","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0095","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jamaneurol.2013.209","article-title":"Long-term outcomes after nonlesional extratemporal lobe epilepsy surgery","volume":"70","author":"Noe","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0100","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S1474-4422(14)70156-5","article-title":"Epilepsy surgery in children and adults","volume":"13","author":"Ryvlin","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1212\/01.wnl.0000286959.22040.6e","article-title":"Quantifying the response to antiepileptic drugs: effect of past treatment history","volume":"70","author":"Schiller","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0110","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1212\/WNL.51.5.1256","article-title":"Is the underlying cause of epilepsy a major prognostic factor for recurrence","volume":"51","author":"Semah","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.23862","article-title":"Improved outcomes with earlier surgery for intractable frontal lobe epilepsy","volume":"73","author":"Simasathien","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/WCO.0000000000000078","article-title":"Epilepsy surgery in MRI-negative epilepsies","volume":"27","author":"So","year":"2014","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0125","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/brain\/awh449","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"T\u00e9llez-Zenteno","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.eplepsyres.2017.07.018_bib0130","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ana.24169","article-title":"Linking MRI postprocessing with magnetic source imaging in MRI-negative epilepsy","volume":"75","author":"Wang","year":"2014","journal-title":"Ann. Neurol."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121117301250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121117301250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:38:27Z","timestamp":1760276307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121117301250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":26,"alternative-id":["S0920121117301250"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2017.07.018","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of a third or later antiepileptic drug regimen according to epilepsy syndrome among adult patients","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2017.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}