{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:17Z","timestamp":1787317757769,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Institute of the McGill University Health Centre"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.eplepsyres.2020.106343","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T02:36:57Z","timestamp":1587263817000},"page":"106343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Serum Levels of Valproic Acid and Carbamazepine Do Not Correlate Well with End-Organ Dysfunction"],"prefix":"10.1016","volume":"163","author":[{"given":"Kenneth A.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzziel","family":"Tamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanakumar V.","family":"Agnihotram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoussen","family":"Berrahmoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2020.106343_bib0005","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2146\/ajhp080454","article-title":"Carbamazepine-induced hyperammonemia","volume":"66","author":"Adams","year":"2009","journal-title":"American Journal of Health-System Pharmacy"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0010","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.25641","article-title":"Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment","volume":"87","author":"A\u00edcua-Rap\u00fan","year":"2020","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0015","unstructured":"Al-Roubaie, Z., Guadagno, E., Agnihotram, R.V., Khan, A.Q., Myers, K.A., (published online). Clinical utility of therapeutic drug monitoring of antiepileptic drugs. Neurology Clinical Practice."},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0020","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1212\/WNL.37.3.379","article-title":"Valproic acid hepatic fatalities: a retrospective review","volume":"37","author":"Dreifuss","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1517\/14656566.9.2.285","article-title":"Oral valproic acid for epilepsy--long-term experience in therapy and side effects","volume":"9","author":"Gerstner","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0030","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/WNL.44.8.1418","article-title":"Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration","volume":"44","author":"Gidal","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1211\/jpp.60.2.0017","article-title":"Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients","volume":"60","author":"Goto","year":"2008","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5455\/medarh.2017.71.239-242","article-title":"Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children","volume":"71","author":"Hadzagic-Catibusic","year":"2017","journal-title":"Med Arch"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.1.6053.83-a","article-title":"Hyponatraemia during carbamazepine treatment","volume":"1","author":"Henry","year":"1977","journal-title":"Br Med J"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1542\/peds.90.1.87","article-title":"The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures","volume":"90","author":"Humphrey","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0055","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1248\/bpb.35.971","article-title":"Correlation between plasma ammonia level and serum trough concentration of free valproic acid in patients with epilepsy","volume":"35","author":"Itoh","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0060","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/j.1875-9114.1986.tb03463.x","article-title":"Acute hepatotoxicity after excessively high doses of carbamazepine on two occasions","volume":"6","author":"Luke","year":"1986","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF02939101","article-title":"Hyponatraemia and carbamazepine intoxication","volume":"149","author":"O\u2019Hare","year":"1980","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0070","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1528-1167.2008.01561.x","article-title":"Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies","volume":"49","author":"Patsalos","year":"2008","journal-title":"Epilepsia"},{"issue":"Suppl 3","key":"10.1016\/j.eplepsyres.2020.106343_bib0075","first-page":"S64","article-title":"Carbamazepine side effects in children and adults","volume":"28","author":"Pellock","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0080","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/jnnp.41.8.713","article-title":"Water intoxication in epileptic patients receiving carbamazepine","volume":"41","author":"Perucca","year":"1978","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0085","first-page":"100","article-title":"Hyperammonaemia and hepatotoxicity during chronic valproate therapy: enhancement by combination with other antiepileptic drugs","volume":"22","author":"Ratnaike","year":"1986","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.eplepsyres.2020.106343_bib0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00004714-198304000-00009","article-title":"Effects of carbamazepine on serum electrolytes: clinical and theoretical implications","volume":"3","author":"Uhde","year":"1983","journal-title":"J Clin Psychopharmacol"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120300887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120300887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:43:44Z","timestamp":1760276624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121120300887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":18,"alternative-id":["S0920121120300887"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106343","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Levels of Valproic Acid and Carbamazepine Do Not Correlate Well with End-Organ Dysfunction","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106343"}}