{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:38:50Z","timestamp":1760315930840,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.eplepsyres.2020.106447","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:10:11Z","timestamp":1598008211000},"page":"106447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy"],"prefix":"10.1016","volume":"167","author":[{"given":"Nobutsune","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2020.106447_bib0005","first-page":"269","article-title":"Effect of Anti-Epileptic drugs on Serum Level of IgG Subclasses","volume":"20","author":"Ashrafi","year":"2010","journal-title":"Iran J Pediatr"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1528-1167.2011.03035.x","article-title":"Antiepileptic drugs and the immune system","volume":"52","author":"Beghi","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2249.2003.02097.x","article-title":"Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood","volume":"132","author":"Callnbach","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1084\/jem.175.3.671","article-title":"Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin","volume":"175","author":"Defrance","year":"1992","journal-title":"A. J Exp Med"},{"issue":"Suppl 3","key":"10.1016\/j.eplepsyres.2020.106447_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1528-1167.2011.03034.x","article-title":"Molecular cascades that mediate the influence of inflammation on epilepsy","volume":"51","author":"Friedman","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/ane.12665","article-title":"Alteration of plasma cytokines in patients with active epilepsy","volume":"135","author":"Gao","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0035","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1212\/WNL.0000000000001558","article-title":"Perampanel efficacy and tolerability with enzyme-inducing AEDs in patients with epilepsy","volume":"84","author":"Gidal","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yebeh.2019.02.004","article-title":"Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy","volume":"94","author":"Ishikawa","year":"2019","journal-title":"Epilepsy & Behav"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.seizure.2019.05.024","article-title":"Successful treatment of intractable life-threatening seizures with perampanel in the first case of early myoclonic encephalopathy with a novel de novo SCN1A mutation","volume":"71","author":"Ishikawa","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.eplepsyres.2012.06.002","article-title":"High concentration of immunoglobulin A is associated with temporal lobe epilepsy","volume":"103","author":"Liimatainen","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0055","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1111\/epi.12337","article-title":"Interictal interleukin-17A levels are elevated and correlate with seizure severity of epilepsy patients","volume":"54","author":"Mao","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.seizure.2011.12.013","article-title":"Carbamazepine-induced hypogammaglobulinemia","volume":"21","author":"Ozaras","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0065","series-title":"Chronic toxicity of antiepileptic drugs","first-page":"269","article-title":"Analysis of B lymphocyte function in drug induced immunoglobulin deficiency","author":"Pereira","year":"1983"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.yebeh.2004.11.017","article-title":"Serum IgA, IgG, and IgM concentrations in patients with epilepsy and matched controls: a cohort-based cross-sectional study","volume":"6","author":"Ranua","year":"2005","journal-title":"Epilepsy & Behav"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0075","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.seizure.2017.03.011","article-title":"Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients","volume":"48","author":"Shih","year":"2017","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yebeh.2016.05.007","article-title":"Safety and efficacy of perampanel in children and adults with various epilepsy syndromes: A single-center postmarketing study","volume":"61","author":"Singh","year":"2016","journal-title":"Epilepsy & Behav"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.coi.2012.03.005","article-title":"IgA synthesis: a form of functional immune adaptation extending beyond gut","volume":"24","author":"Sutherland","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0404.2010.01372.x","article-title":"Cardiovascular risk factors in epilepsy patients taking levetiracetam, carbamazepine or lamotrigine","volume":"122","author":"Svalheim","year":"2010","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ane.12044","article-title":"Reduced immunoglobulin levels in epilepsy patients treated with levetiracetam, lamotrigine, or carbamazepine","volume":"127","author":"Svalheim","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106447_bib0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1440-1754.1997.tb01588.x","article-title":"Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants","volume":"33","author":"Verroti","year":"1997","journal-title":"J Paediatr Child Health"},{"issue":"Suppl 5","key":"10.1016\/j.eplepsyres.2020.106447_bib0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1528-1157.43.s.5.14.x","article-title":"Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis","volume":"43","author":"Vezzani","year":"2002","journal-title":"Epilepsia"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120304976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120304976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:44:29Z","timestamp":1760276669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121120304976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":22,"alternative-id":["S0920121120304976"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106447","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106447"}}