{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:24:54Z","timestamp":1762431894310,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.eplepsyres.2020.106461","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T21:26:24Z","timestamp":1599686784000},"page":"106461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-312X","authenticated-orcid":false,"given":"Jessica","family":"Berkvens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-8122","authenticated-orcid":false,"given":"Marian","family":"Majoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-2942","authenticated-orcid":false,"given":"Sandra","family":"Mergler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6679-7177","authenticated-orcid":false,"given":"Kim","family":"Beerhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Verschuure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0496-8209","authenticated-orcid":false,"given":"In","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-2232","authenticated-orcid":false,"given":"Joop van","family":"den Bergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2020.106461_bib0005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1528-1157.1989.tb05308.x","article-title":"Risk of age-related fractures in patients with unprovoked seizures","volume":"30","author":"Annegers","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ane.12118","article-title":"Antiepileptic drugs and high prevalence of low bone mineral density in a group of inpatients with chronic epilepsy","volume":"128","author":"Beerhorst","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0015","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1359\/jbmr.1999.14.5.821","article-title":"Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures","volume":"14","author":"Black","year":"1999","journal-title":"Study of Osteoporotic Fractures Research Group. J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0020","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.2009.50","article-title":"Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women","volume":"301","author":"Bliuc","year":"2009","journal-title":"Jama"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0025","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1359\/jbmr.080411","article-title":"Prevalent vertebral fractures in black women and white women","volume":"23","author":"Cauley","year":"2008","journal-title":"J Bone Miner Res"},{"year":"2011","series-title":"Richtlijn Osteoporose en Fractuurpreventie","author":"CBO","key":"10.1016\/j.eplepsyres.2020.106461_bib0030"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbmr.5650070214","article-title":"Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989","volume":"7","author":"Cooper","year":"1992","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0040","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0045","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S8756-3282(03)00241-2","article-title":"Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial","volume":"33","author":"Delmas","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1359\/JBMR.041214","article-title":"Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study","volume":"20","author":"Delmas","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/bmj.4.5727.69","article-title":"Osteomalacia with long-term anticonvulsant therapy in epilepsy","volume":"4","author":"Dent","year":"1970","journal-title":"Br Med J"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0020-1383(95)00189-1","article-title":"Incidence of five common fracture types in an institutional epileptic population","volume":"27","author":"Desai","year":"1996","journal-title":"Injury"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106511","article-title":"An explorative literature review of the multifactorial causes of osteoporosis in epilepsy","volume":"100","author":"Diemar","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0070","first-page":"17","article-title":"The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism","author":"Fan","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0075","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1359\/JBMR.050314","article-title":"What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa?","volume":"20","author":"Fink","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0080","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1210\/jc.2004-0826","article-title":"Teriparatide reduces the fracture risk associated with increasing number and severity of osteoporotic fractures","volume":"90","author":"Gallagher","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0085","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/epi.14738","article-title":"Bone fractures from generalized convulsive seizures and status epilepticus-A systematic review","volume":"60","author":"Grzonka","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2165\/00003495-197612030-00003","article-title":"Bone complications of anticonvulsants","volume":"12","author":"Hahn","year":"1976","journal-title":"Drugs"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1503\/cmaj.081720","article-title":"Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study","volume":"181","author":"Ioannidis","year":"2009","journal-title":"Cmaj"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0105","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/archinte.159.11.1215","article-title":"Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group","volume":"159","author":"Kado","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0110","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01622200","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report","volume":"4","author":"Kanis","year":"1994","journal-title":"WHO Study Group. Osteoporos Int"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0115","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/jbmr.2002.17.6.1051","article-title":"The incidence of vertebral fractures in men and women: the Rotterdam Study","volume":"17","author":"van der Klift","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0120","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/epi.12351","article-title":"Prevention of bone loss and vertebral fractures in patients with chronic epilepsy--antiepileptic drug and osteoporosis prevention trial","volume":"54","author":"Lazzari","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.amjopharm.2010.02.003","article-title":"A review of the effect of anticonvulsant medications on bone mineral density and fracture risk","volume":"8","author":"Lee","year":"2010","journal-title":"Am J Geriatr Pharmacother"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0130","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1600-0404.1971.tb07517.x","article-title":"Bone density in patients receiving long-term anticonvulsant therapy","volume":"47","author":"Linde","year":"1971","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jama.285.3.320","article-title":"Risk of new vertebral fracture in the year following a fracture","volume":"285","author":"Lindsay","year":"2001","journal-title":"Jama"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01623271","article-title":"Prevalence and incidence of vertebral deformities","volume":"3","author":"Melton","year":"1993","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s001980050218","article-title":"Vertebral fractures predict subsequent fractures","volume":"10","author":"Melton","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2019.116422","article-title":"How safe is bone health in patients on newer or enzyme inhibitor antiepileptic drugs?","volume":"405","author":"Mitta","year":"2019","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0155","first-page":"131","article-title":"Risk factors for a first-incident radiographic vertebral fracture in women & or = 65 years of age: the study of osteoporotic fractures","volume":"20","author":"Nevitt","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bone.2014.04.018","article-title":"Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis","volume":"64","author":"Shen","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1212\/WNL.0b013e31825f0466","article-title":"Falls and fractures in patients chronically treated with antiepileptic drugs","volume":"79","author":"Shiek Ahmad","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0170","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00198-006-0306-8","article-title":"Enhanced prediction of fracture risk combining vertebral fracture status and BMD","volume":"18","author":"Siris","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0175","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1528-1157.1973.tb03967.x","article-title":"Compression fractures of the vertebrae during major epileptic seizures","volume":"14","author":"Vasconcelos","year":"1973","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0180","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0404.1999.tb00675.x","article-title":"Fracture risk is increased in epilepsy","volume":"99","author":"Vestergaard","year":"1999","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.eplepsyres.2020.106461_bib0185","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-0404.2005.00474.x","article-title":"Epilepsy, osteoporosis and fracture risk - a meta-analysis","volume":"112","author":"Vestergaard","year":"2005","journal-title":"Acta Neurol Scand"},{"year":"2018","series-title":"Epilepsy","author":"WHO","key":"10.1016\/j.eplepsyres.2020.106461_bib0190"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120305118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121120305118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:44:57Z","timestamp":1760276697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121120305118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":38,"alternative-id":["S0920121120305118"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106461","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106461"}}