{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:27:28Z","timestamp":1791397648925,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.eplepsyres.2022.106860","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:32:01Z","timestamp":1642451521000},"page":"106860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Evaluation of QT dispersion in epileptic patients and its association with SUDEP risk"],"prefix":"10.1016","volume":"180","author":[{"given":"Rehab M.","family":"Hamdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola H. Abd","family":"Elaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Sobhy","family":"El attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayam","family":"Abdel-Tawab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma M.","family":"Kotb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2022.106860_bib1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1651-2227.2003.tb00624.x","article-title":"Increased QT dispersion in epileptic children","volume":"92","author":"Akalin","year":"2007","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib2","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1111\/j.1528-1157.1997.tb06137.x","article-title":"United States perspective on definitions and classifications","volume":"38","author":"Annegers","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/heartjnl-2014-305664","article-title":"Sudden cardiac death is associated both with epilepsy and with use of antiepileptic medications","volume":"101","author":"Bardai","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib4","first-page":"7","article-title":"Epilepsy is a risk factor for sudden cardiac arrest in the general population","author":"Bardai","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.yebeh.2017.04.018","article-title":"Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy","volume":"71","author":"Baysal-Kirac","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/003655100750046486","article-title":"QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes","volume":"60","author":"Christensen","year":"2000","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13760-019-01182-8","article-title":"Evaluation of electrocardiographic parameters in patients with epileptic seizure","volume":"120","author":"Dagar","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2010.06.011","article-title":"RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: The SUDEP-7 Inventory","volume":"19","author":"DeGiorgio","year":"2010","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib9","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1212\/WNL.0000000000005740","article-title":"Incidence of cardiac fibrosis in SUDEP and control cases","volume":"91","author":"Devinsky","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.eplepsyres.2010.04.008","article-title":"Evaluation of cardiac repolarization indices in well-controlled partial epilepsy: 12-Lead ECG findings","volume":"90","author":"Dogan","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1136\/jnnp.54.10.873","article-title":"The chalfont seizure severity scale","volume":"54","author":"Duncan","year":"1991","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib12","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.0b013e3181a55f90","article-title":"Sudden unexpected near death in epilepsy: malignant arrhythmia from a partial seizure","volume":"72","author":"Espinosa","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib13","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1111\/epi.14084","article-title":"Increased cardiac stiffness is associated with autonomic dysfunction in patients with temporal lobe epilepsy","volume":"59","author":"Fialho","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib14","first-page":"324","article-title":"Physiological limits of variations in heart rate measured by the Holter method in 134 normal subjects","volume":"79","author":"Grosgogeat","year":"1986","journal-title":"Arch. Mal. Coeur Vaiss."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib15","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1212\/WNL.0000000000003685","article-title":"Practice guideline summary: sudden unexpected death in epilepsy incidence rates and risk factors: report of the guideline development, dissemination, and implementation subcommittee of the american academy of neurology and the American Epilepsy Society","volume":"88","author":"Harden","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yebeh.2006.11.010","article-title":"Sudden unexpected death in epilepsy: A search for risk factors","volume":"10","author":"Hitiris","year":"2007","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.seizure.2010.07.008","article-title":"Cardiac changes in epilepsy","volume":"19","author":"Jansen","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yebeh.2017.10.028","article-title":"Interictal cardiac repolarization abnormalities in people with epilepsy","volume":"79","author":"Kishk","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.yebeh.2013.07.021","article-title":"Interictal 12-lead electrocardiography in patients with epilepsy","volume":"29","author":"Krishnan","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/jnnp-2014-307772","article-title":"Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy","volume":"86","author":"Lamberts","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1540-8159.2011.03276.x","article-title":"Cardiac arrhythmias and sudden unexpected death in epilepsy (SUDEP)","volume":"35","author":"Laurence","year":"2012","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2362.2003.01123.x","article-title":"Effects of adrenaline and potassium on QTc interval and QT dispersion in man","volume":"33","author":"Lee","year":"2003","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib24","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/epi.16301","article-title":"Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance","volume":"60","author":"Li","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","article-title":"Heart rate variability standards of measurement, physiological interpretation, and clinical use task force of the european society of cardiology and the north american society of pacing and electrophysiology (membership of the task force listed in the app","volume":"17","author":"Malik","year":"1996","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib26","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.hrthm.2017.05.002","article-title":"Percentile categorization of QT interval as an approach for identifying adult patients at risk for cardiovascular death","volume":"14","author":"Mohebi","year":"2017","journal-title":"Hear. Rhythm"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.eplepsyres.2009.03.021","article-title":"Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies","volume":"85","author":"Mukherjee","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the american society of echocardiography and the european association of cardiovascular imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s41983-020-00257-1","article-title":"Corrected QT interval and QT dispersion in temporal lobe epilepsy","volume":"57","author":"Nasef","year":"2021","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib30","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1111\/j.1528-1157.1997.tb06130.x","article-title":"Sudden unexpected death in epilepsy: terminology and definitions","volume":"38","author":"Nashef","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000233236","article-title":"Cardiac repolarization indices in epilepsy patients","volume":"114","author":"Neufeld","year":"2009","journal-title":"Cardiology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000233236","article-title":"Cardiac repolarization indices in epilepsy patients","volume":"114","author":"Neufeld","year":"2009","journal-title":"Cardiology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib33","first-page":"7","article-title":"Correlation between seizure in children and prolonged QT interval","volume":"9","author":"Sadrnia","year":"2013","journal-title":"ARYA Atheroscler."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib35","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1111\/j.1528-1167.2011.03262.x","article-title":"Seizure-related cardiac repolarization abnormalities are associated with ictal hypoxemia","volume":"52","author":"Seyal","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1212\/WNL.34.2.255","article-title":"No titlechanges in plasma catecholamines after tonic-clonic seizures","volume":"34","author":"Simon","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5698\/1535-7511-16.3.166","article-title":"Seizures, Epilepsy, and SUDEP: a change of heart?","volume":"16","author":"Smith","year":"2016","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jacc.2005.08.067","article-title":"Prolonged QTc interval and risk of sudden cardiac death in a population of older adults","volume":"47","author":"Straus","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1528-1167.2009.02330.x","article-title":"Pathologic cardiac repolarization in pharmacoresistant epilepsy and its potential role in sudden unexpected death in epilepsy: a case-control study","volume":"51","author":"Surges","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1212\/WNL.0b013e3181e79277","article-title":"Enhanced Qt shortening and persistent tachycardia after gereralized seizures","volume":"75","author":"Surges","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1440-1819.1998.00446.x","article-title":"Interictal change in cardiac autonomic function associated with eeg abnormalities and clinical symptoms: a longitudinal study following acute deterioration in two patients with temporal lobe epilepsy","volume":"52","author":"Toichi","year":"1998","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib42","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1111\/epi.16966","article-title":"Epileptic heart: a clinical syndromic approach","volume":"62","author":"Verrier","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1212\/WNL.56.4.519","article-title":"Incidence and risk factors in sudden unexpected death in epilepsy","volume":"56","author":"Walczak","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2022.106860_bib44","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.yebeh.2010.12.001","article-title":"Analysis of 24-hour heart rate variations in patients with epilepsy receiving antiepileptic drugs","volume":"20","author":"Yildiz","year":"2011","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2022.106860_bib45","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.yebeh.2019.05.038","article-title":"Comorbidity between epilepsy and cardiac arrhythmias: implication for treatment","volume":"97","author":"Zaccara","year":"2019","journal-title":"Epilepsy Behav."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121122000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121122000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:46:16Z","timestamp":1760276776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121122000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":45,"alternative-id":["S0920121122000110"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2022.106860","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of QT dispersion in epileptic patients and its association with SUDEP risk","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2022.106860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106860"}}