{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:38:02Z","timestamp":1762317482336,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003454","name":"Guangxi Zhuang Autonomous Region Health Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.eplepsyres.2025.107591","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:45:43Z","timestamp":1747309543000},"page":"107591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Efficacy and safety of perampanel in genetic generalized epilepsy: A retrospective, single-center study in China"],"prefix":"10.1016","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-7886","authenticated-orcid":false,"given":"Hua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2025.107591_bib1","article-title":"Efficacy and tolerability of perampanel in patients with genetic generalized epilepsy (GGE): a retrospective, single-center study from the United Arab Emirates (UAE)","volume":"12","author":"Alsaadi","year":"2019","journal-title":"Epilepsy Behav. Rep."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.seizure.2020.06.011","article-title":"Adjunctive perampanel and myoclonic and absence seizures: post hoc analysis of data from study 332 in patients with idiopathic generalized epilepsy","volume":"80","author":"Brandt","year":"2020","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.eplepsyres.2025.107591_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/epi.12175","article-title":"Road to refractory epilepsy: the glasgow story","volume":"54","author":"Brodie","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2024.107339","article-title":"Perampanel for the treatment of epilepsy with genetic aetiology: Real-world evidence from the PERMIT Extension study","volume":"202","author":"Delanty","year":"2024","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib5","doi-asserted-by":"crossref","unstructured":"Falco-Walter, J.J., Scheffer, I.E., Fisher. R.S.,2018. The new definition and classification of seizures and epilepsy.Epilepsy Res 139:73-79. https:\/\/doi: 10.1016\/j.eplepsyres.","DOI":"10.1016\/j.eplepsyres.2017.11.015"},{"issue":"3","key":"10.1016\/j.eplepsyres.2025.107591_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/epi4.12602","article-title":"Long-term open-label perampanel: generalized tonic\u2013clonic seizures in idiopathic generalized epilepsy","volume":"7","author":"French","year":"2022","journal-title":"Epilepsia Open"},{"issue":"4","key":"10.1016\/j.eplepsyres.2025.107591_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/epi4.12649","article-title":"Effectiveness of perampanel as the only add-on: retrospective, multicenter, observational real-life study on epilepsy patients","volume":"7","author":"Gasparini","year":"2022","journal-title":"Epilepsia Open"},{"issue":"10","key":"10.1016\/j.eplepsyres.2025.107591_bib8","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.eplepsyres.2014.09.008","article-title":"Seizure outcome in 175 patients with juvenile myoclonic epilepsy: a long-term observational study","volume":"108","author":"H\u00f6fler","year":"2014","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.eplepsyres.2025.107591_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/ane.13556","article-title":"Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients","volume":"145","author":"Irelli","year":"2022","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.seizure.2019.05.024","article-title":"Successful treatment of intractable life-threatening seizures with perampanel in the first case of early myoclonic encephalopathy with a novel de novo SCN1A mutation","volume":"71","author":"Ishikawa","year":"2019","journal-title":"Seizure"},{"issue":"4","key":"10.1016\/j.eplepsyres.2025.107591_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/ane.13567","article-title":"Treatment outcomes in women with idiopathic generalized epilepsy","volume":"145","author":"Kiiski","year":"2022","journal-title":"Acta Neurol. Scand."},{"issue":"3","key":"10.1016\/j.eplepsyres.2025.107591_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/17460441.2019.1566318","article-title":"The impact of perampanel and targeting AMPA transmission on anti-seizure drug discovery","volume":"14","author":"Lattanzi","year":"2019","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1120150","article-title":"Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: evidence from the PERMIT study","volume":"14","author":"Liguori","year":"2023","journal-title":"Front Neurol."},{"issue":"11","key":"10.1016\/j.eplepsyres.2025.107591_bib14","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/epi.17058","article-title":"Epilepsy centers in China: current status and ways forward","volume":"62","author":"Lin","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.seizure.2024.01.011","article-title":"Efficacy and safety of perampanel as the first add-on therapy for children with epilepsy: A real-world multicenter prospective observational study","volume":"117","author":"Mai","year":"2024","journal-title":"Seizure"},{"issue":"9566","key":"10.1016\/j.eplepsyres.2025.107591_bib16","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(07)60461-9","article-title":"The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.eplepsyres.2025.107591_bib17","first-page":"75","article-title":"The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies","volume":"75","author":"Nicolson","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.eplepsyres.2025.107591_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neurol.2020.03.018","article-title":"Genetic\/idiopathic generalized epilepsies: not so good as that!","volume":"176","author":"Nilo","year":"2020","journal-title":"Rev. Neurol. (Paris)"},{"issue":"4","key":"10.1016\/j.eplepsyres.2025.107591_bib19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/epi.17530","article-title":"Perampanel as precision therapy in rare genetic epilepsies","volume":"64","author":"Nissenkorn","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib20","doi-asserted-by":"crossref","DOI":"10.1177\/17562864221101687","article-title":"Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide","volume":"15","author":"Nucera","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib21","article-title":"Successful use of perampanel in GABRA1-related myoclonic epilepsy with photosensitivity","volume":"19","author":"Olivotto","year":"2022","journal-title":"Epilepsy Behav. Rep."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.952900","article-title":"Perampanel and childhood absence epilepsy: a real life experience","volume":"13","author":"Operto","year":"2022","journal-title":"Front Neurol."},{"issue":"8","key":"10.1016\/j.eplepsyres.2025.107591_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrneurol.2010.92","article-title":"Genetic evaluation and counseling for epilepsy","volume":"6","author":"Pal","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2025.107591_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16718-x","article-title":"Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy","volume":"12","author":"Pipek","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib25","doi-asserted-by":"crossref","DOI":"10.1684\/epd.2022.1443","article-title":"Use of perampanel in children with refractory epilepsy of genetic aetiology","author":"Qu","year":"2022","journal-title":"Epileptic Disord24(4):687-695"},{"issue":"12","key":"10.1016\/j.eplepsyres.2025.107591_bib26","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00109-023-02383-8","article-title":"Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome","volume":"101","author":"Ricobaraza","year":"2023","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107935","article-title":"Efficacy and tolerability of adjuvant perampanel: an Australian multicenter real-world observational study in refractory focal and generalized epilepsy syndromes","volume":"119","author":"Sagar","year":"2021","journal-title":"Epilepsy Behav."},{"issue":"24","key":"10.1016\/j.eplepsyres.2025.107591_bib28","first-page":"2128","article-title":"Prognosis of juvenile myoclonic epilepsy 45 years after onset: seizure outcome and predictors","volume":"81","author":"Senf","year":"2013","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.eplepsyres.2025.107591_bib29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.biopsych.2019.12.025","article-title":"Low-dose perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic syngap1+\u2009\/- mice","volume":"87","author":"Sullivan","year":"2020","journal-title":"Biol. Psychiatry"},{"issue":"10","key":"10.1016\/j.eplepsyres.2025.107591_bib30","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00415-004-0521-1","article-title":"Long-term prognosis for childhood and juvenile absence epilepsy","volume":"251","author":"Trinka","year":"2004","journal-title":"J. Neurol."},{"issue":"10","key":"10.1016\/j.eplepsyres.2025.107591_bib31","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/jnnp-2011-300376","article-title":"KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy","volume":"84","author":"Trinka","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"8","key":"10.1016\/j.eplepsyres.2025.107591_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s40263-021-00831-y","article-title":"Exploring the evidence for broad-spectrum effectiveness of perampanel: a systematic review of clinical data in generalised seizures","volume":"35","author":"Trinka","year":"2021","journal-title":"CNS Drugs"},{"issue":"8","key":"10.1016\/j.eplepsyres.2025.107591_bib33","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/epi.17631","article-title":"Perampanel for the treatment of people with idiopathic generalized epilepsy in clinical practice","volume":"64","author":"Trinka","year":"2023","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.eplepsyres.2025.107591_bib34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/epi.14522","article-title":"Perampanel in routine clinical use in idiopathic generalized epilepsy: the 12-month GENERAL study","volume":"59","author":"Villanueva","year":"2018","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.eplepsyres.2025.107591_bib35","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1080\/00207454.2022.2032045","article-title":"Efficacy and safety of perampanel for the treatment of epilepsy in adolescents: a meta-analysis","volume":"133","author":"Wang","year":"2023","journal-title":"Int J. Neurosci."},{"issue":"6","key":"10.1016\/j.eplepsyres.2025.107591_bib36","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/epi.17237","article-title":"Methodology for classification and definition of epilepsy syndromes with list of syndromes: report of the ILAE task force on nosology and definitions","volume":"63","author":"Wirrell","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2025.107591_bib37","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fphar.2022.1026836","article-title":"Effectiveness of perampanel in the treatment of pediatric patients with focal epilepsy and ESES: a single-center retrospective study","volume":"13","author":"Yu","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.eplepsyres.2025.107591_bib38","article-title":"Effectiveness and tolerability of perampanel monotherapy in children with newly diagnosed focal epilepsy","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Neurol."}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121125000920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121125000920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:34:29Z","timestamp":1762317269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121125000920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"alternative-id":["S0920121125000920"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2025.107591","relation":{},"ISSN":["0920-1211"],"issn-type":[{"type":"print","value":"0920-1211"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of perampanel in genetic generalized epilepsy: A retrospective, single-center study in China","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2025.107591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107591"}}