{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:45:13Z","timestamp":1776768313543,"version":"3.51.2"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.eplepsyres.2026.107757","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:37:12Z","timestamp":1771519032000},"page":"107757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Landscaping evidence on first-line therapies for infantile epileptic spasms syndrome: An umbrella review"],"prefix":"10.1016","volume":"222","author":[{"given":"Saroj Kundan","family":"Bharti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manya","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Safeer","family":"V S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Madaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chellamani","family":"Harini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra Kumar","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-3293","authenticated-orcid":false,"given":"Dipika","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eplepsyres.2026.107757_bib1","doi-asserted-by":"crossref","unstructured":"Aromataris, E., et al., Chapter 10: Umbrella Reviews. 2020.","DOI":"10.46658\/JBIRM-17-08"},{"issue":"10","key":"10.1016\/j.eplepsyres.2026.107757_bib2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1177\/0883073812453203","article-title":"Corticosteroids for the treatment of infantile spasms: a systematic review","volume":"27","author":"Arya","year":"2012","journal-title":"J. Child Neurol."},{"issue":"3","key":"10.1016\/j.eplepsyres.2026.107757_bib3","article-title":"Comparison of efficacy and safety of low- versus high-dose oral prednisolone in Infantile Spasm (IS): an open label randomized controlled trial at the children's hospital & institute of child health, Multan, Pakistan","volume":"14","author":"Basit","year":"2022","journal-title":"Cureus"},{"issue":"11","key":"10.1016\/j.eplepsyres.2026.107757_bib4","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1002\/acn3.50922","article-title":"Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis","volume":"6","author":"Chang","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"8","key":"10.1016\/j.eplepsyres.2026.107757_bib5","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.eplepsyres.2014.06.019","article-title":"High dose (4 mg\/kg\/day) versus usual dose (2 mg\/kg\/day) oral prednisolone for treatment of infantile spasms: an open-label, randomized controlled trial","volume":"108","author":"Chellamuthu","year":"2014","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.eplepsyres.2026.107757_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/jamapediatrics.2022.5648","article-title":"Efficacy and safety of dietary therapies for childhood drug-resistant epilepsy: a systematic review and network meta-analysis","volume":"177","author":"Devi","year":"2023","journal-title":"JAMA Pedia"},{"issue":"6","key":"10.1016\/j.eplepsyres.2026.107757_bib7","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/epi4.13086","article-title":"First-choice hormonal therapies for children with infantile epileptic spasms syndrome in South Asia: a network meta-analysis of randomized controlled trials","volume":"9","author":"Devi","year":"2024","journal-title":"Epilepsia Open"},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36469\/jheor.2021.18727","article-title":"A systematic literature review and indirect treatment comparison of efficacy of repository corticotropin injection versus synthetic adrenocorticotropic hormone for infantile spasms","volume":"8","author":"Duchowny","year":"2021","journal-title":"J. Health Econ. Outcomes Res"},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib9","first-page":"17","article-title":"Comparison of the effect of high and low doses of adrenocorticotropic hormone (ACTH) in the management of infantile spasms","volume":"14","author":"Fayyazi","year":"2020","journal-title":"Iran. J. Child Neurol."},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1055\/a-2517-7800","article-title":"Adrenocorticotropic hormone versus prednisolone for infantile epileptic spasms syndrome: a systematic review and economic evaluation","volume":"56","author":"Gao","year":"2025","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070849","article-title":"Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement","volume":"378","author":"Gates","year":"2022","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12098-018-2782-1","article-title":"Corticotrophin-ACTH in comparison to prednisolone in West syndrome - a randomized study","volume":"86","author":"Gowda","year":"2019","journal-title":"Indian J. Pedia"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib13","doi-asserted-by":"crossref","first-page":"f7450","DOI":"10.1136\/bmj.f7450","article-title":"Converting an odds ratio to a range of plausible relative risks for better communication of research findings","volume":"348","author":"Grant","year":"2014","journal-title":"BMJ Br. Med. J."},{"issue":"8","key":"10.1016\/j.eplepsyres.2026.107757_bib14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.seizure.2013.04.015","article-title":"Molecular mechanisms of antiseizure drug activity at GABAA receptors.","volume":"22","author":"Greenfield","year":"2013","journal-title":"Seizure"},{"issue":"12","key":"10.1016\/j.eplepsyres.2026.107757_bib15","doi-asserted-by":"crossref","first-page":"e1217","DOI":"10.1212\/WNL.0000000000012511","article-title":"Comparative effectiveness of initial treatment for infantile spasms in a contemporary US cohort","volume":"97","author":"Grinspan","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.772333","article-title":"Hormonal therapy for infantile spasms: a systematic review and meta-analysis","volume":"13","author":"Guang","year":"2022","journal-title":"Front. Neurol."},{"issue":"4","key":"10.1016\/j.eplepsyres.2026.107757_bib17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jclinepi.2010.09.011","article-title":"GRADE guidelines: a new series of articles in the journal of clinical epidemiology","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"issue":"6","key":"10.1016\/j.eplepsyres.2026.107757_bib18","first-page":"Cd001770","article-title":"Treatment of infantile spasms","volume":"2013","author":"Hancock","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jrsm.1390","article-title":"Examining overlap of included studies in meta-reviews: guidance for using the corrected covered area index","volume":"11","author":"Hennessy","year":"2020","journal-title":"Res Synth. Methods"},{"issue":"4","key":"10.1016\/j.eplepsyres.2026.107757_bib20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0022-3476(83)80606-4","article-title":"Double-blind study of ACTH vs prednisone therapy in infantile spasms","volume":"103","author":"Hrachovy","year":"1983","journal-title":"J. Pedia"},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/epi.12460","article-title":"Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone","volume":"55","author":"Hussain","year":"2014","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.eplepsyres.2026.107757_bib22","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/dmcn.15330","article-title":"Treatment of children with infantile spasms: a network meta-analysis","volume":"64","author":"Jain","year":"2022","journal-title":"Dev. Med Child Neurol."},{"issue":"11","key":"10.1016\/j.eplepsyres.2026.107757_bib23","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/epi.13557","article-title":"Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort","volume":"57","author":"Knupp","year":"2016","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.eplepsyres.2026.107757_bib24","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/epi.17918","article-title":"Efficacy and safety of corticosteroids and ACTH in epileptic syndromes beyond infantile epileptic spasms syndrome (IESS): a systematic review and meta-analysis","volume":"65","author":"Korinthenberg","year":"2024","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.eplepsyres.2026.107757_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.yebeh.2009.01.023","article-title":"High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH","volume":"14","author":"Kossoff","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pediatrneurol.2025.09.001","article-title":"A proof-of-concept study on effectiveness of nitrazepam in resistant infantile epileptic spasms syndrome (NitRIS Trial)","volume":"173","author":"Lal","year":"2025","journal-title":"Pedia Neurol."},{"issue":"5","key":"10.1016\/j.eplepsyres.2026.107757_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/dmcn.14452","article-title":"Prednisolone\/prednisone as adrenocorticotropic hormone alternative for infantile spasms: a meta-analysis of randomized controlled trials","volume":"62","author":"Li","year":"2020","journal-title":"Dev. Med Child Neurol."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib28","unstructured":"London, U.Ng.N. Epilepsies in children, young people and adults. NICE guideline NG217 2025; Available from: \u3008https:\/\/www.nice.org.uk\/guidance\/ng217\u3009."},{"issue":"7","key":"10.1016\/j.eplepsyres.2026.107757_bib29","first-page":"656","article-title":"[Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis]","volume":"21","author":"Luo","year":"2019","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"10","key":"10.1016\/j.eplepsyres.2026.107757_bib30","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1212\/01.WNL.0000127773.72699.C8","article-title":"Practice parameter: medical treatment of infantile spasms: report of the American academy of neurology and the child neurology society","volume":"62","author":"Mackay","year":"2004","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.eplepsyres.2026.107757_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/epi4.12419","article-title":"Management practices for West syndrome in South Asia: a survey study and meta-analysis","volume":"5","author":"Madaan","year":"2020","journal-title":"Epilepsia Open"},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1474-4422(16)30294-0","article-title":"Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial","volume":"16","author":"O'Callaghan","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib33","article-title":"Introduction to the GRADE tool for rating certainty in evidence and recommendations","volume":"25","author":"Prasad","year":"2024","journal-title":"Clin. Epidemiol. Glob. Health"},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/ane.12830","article-title":"Efficacy of ketogenic diet for infantile spasms: a systematic review","volume":"137","author":"Prezioso","year":"2018","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib35","doi-asserted-by":"crossref","first-page":"g5630","DOI":"10.1136\/bmj.g5630","article-title":"A GRADE working group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"Puhan","year":"2014","journal-title":"Bmj"},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/epi4.12895","article-title":"Initial combination versus early sequential standard therapies for infantile epileptic spasms syndrome\u2014feedback from stakeholders","volume":"9","author":"Ramani","year":"2024","journal-title":"Epilepsia Open"},{"issue":"6","key":"10.1016\/j.eplepsyres.2026.107757_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/a-1909-2977","article-title":"Treatment of infantile spasm syndrome: update from the interdisciplinary guideline committee coordinated by the German-speaking society of neuropediatrics","volume":"53","author":"Ramantani","year":"2022","journal-title":"Neuropediatrics"},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/epi.13981","article-title":"Comparative efficacy of antiepileptic drugs in children and adolescents: a network meta-analysis","volume":"59","author":"Rosati","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib39","article-title":"The landscape of infantile epileptic spasms syndrome in South Asia: peculiarities, challenges, and way forward","volume":"12","author":"Sahu","year":"2023","journal-title":"Lancet Reg. Health Southeast Asia"},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/epi.16799","article-title":"Cost-effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms","volume":"62","author":"S\u00e1nchez Fern\u00e1ndez","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib41","doi-asserted-by":"crossref","DOI":"10.1590\/1518-8345.2885.3074","article-title":"The Joanna Briggs Institute approach for systematic reviews","volume":"26","author":"Santos","year":"2018","journal-title":"Rev. Lat. Am. Enferm."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib42","series-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.3","article-title":"Completing \u2018summary of findings\u2019 tables and grading the certainty of the evidence","author":"Sch\u00fcnemann","year":"2022"},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s13312-021-2097-6","article-title":"Association of child neurology (AOCN) \u2014 Indian epilepsy society (IES) consensus guidelines for the diagnosis and management of West syndrome","volume":"58","author":"Sharma","year":"2021","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.eplepsyres.2026.107757_bib44","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.eplepsyres.2026.107757_bib45","first-page":"744","article-title":"Adrenocorticotropic hormone for the treatment of West syndrome in children","volume":"47","author":"Shumiloff","year":"2013","journal-title":"Ann. Pharm."},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/WNF.0000000000000200","article-title":"Efficacy of treatments for infantile spasms: a systematic review","volume":"40","author":"Song","year":"2017","journal-title":"Clin. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.eplepsyres.2026.107757_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/epi4.12666","article-title":"Medical treatment in infants and young children with epilepsy: off-label use of antiseizure medications. Survey report of ILAE task force medical therapies in children","volume":"8","author":"Sourbron","year":"2023","journal-title":"Epilepsia Open"},{"issue":"3","key":"10.1016\/j.eplepsyres.2026.107757_bib48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pediatrneurol.2015.05.004","article-title":"Randomized, single-blind, parallel clinical trial on efficacy of oral prednisolone versus intramuscular corticotropin on immediate and continued spasm control in West syndrome","volume":"53","author":"Wanigasinghe","year":"2015","journal-title":"Pedia Neurol."},{"issue":"2","key":"10.1016\/j.eplepsyres.2026.107757_bib49","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/epi4.12703","article-title":"Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: a systematic review and meta-analysis","volume":"8","author":"Xu","year":"2023","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.eplepsyres.2026.107757_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3233\/JPN-2011-0469","article-title":"Efficacy of high-dose ACTH versus low-dose ACTH in infantile spasms: a meta-analysis with direct and indirect comparison of randomized trials","volume":"9","author":"Zeng","year":"2011","journal-title":"J. Pediatr. Neurol."},{"issue":"6","key":"10.1016\/j.eplepsyres.2026.107757_bib51","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/epi.17239","article-title":"ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: position statement by the ILAE task force on nosology and definitions","volume":"63","author":"Zuberi","year":"2022","journal-title":"Epilepsia"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121126000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121126000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:42:08Z","timestamp":1775072528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121126000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":51,"alternative-id":["S0920121126000276"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2026.107757","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Landscaping evidence on first-line therapies for infantile epileptic spasms syndrome: An umbrella review","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2026.107757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107757"}}