{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:25:34Z","timestamp":1774902334530,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800683"],"award-info":[{"award-number":["81800683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902717"],"award-info":[{"award-number":["81902717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013104","name":"Shanghai Health and Medical Development Foundation","doi-asserted-by":"publisher","award":["805344"],"award-info":[{"award-number":["805344"]}],"id":[{"id":"10.13039\/501100013104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.eprac.2021.01.007","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:36:45Z","timestamp":1611056205000},"page":"736-742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["KCNJ5 Mutation Contributes to Complete Clinical Success in Aldosterone-Producing Adenoma: A Study From a Single Center"],"prefix":"10.1016","volume":"27","author":[{"given":"Cui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingwei","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.eprac.2021.01.007_bib1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/HJH.0b013e328360ddf6","article-title":"Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in China","volume":"31","author":"Sang","year":"2013","journal-title":"J\u00a0Hypertens"},{"issue":"14","key":"10.1016\/j.eprac.2021.01.007_bib2","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.eprac.2021.01.007_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"10.1016\/j.eprac.2021.01.007_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/SLA.0b013e318165c075","article-title":"The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronoma","volume":"247","author":"Zarnegar","year":"2008","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.eprac.2021.01.007_bib6","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/SLA.0000000000003200","article-title":"The primary aldosteronism surgical outcome score for the prediction of clinical outcomes after adrenalectomy for unilateral primary aldosteronism","volume":"272","author":"Burrello","year":"2020","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0031-1299681","article-title":"Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a review","volume":"44","author":"Steichen","year":"2012","journal-title":"Horm Metab Res"},{"issue":"9","key":"10.1016\/j.eprac.2021.01.007_bib8","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1097\/HJH.0b013e3283060f0c","article-title":"Blood pressure outcome of adrenalectomy in patients with primary hyperaldosteronism with or without unilateral adenoma","volume":"26","author":"Letavernier","year":"2008","journal-title":"J\u00a0Hypertens"},{"issue":"6018","key":"10.1016\/j.eprac.2021.01.007_bib9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.eprac.2021.01.007_bib10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.eprac.2021.01.007_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"issue":"15","key":"10.1016\/j.eprac.2021.01.007_bib12","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJMoa1504869","article-title":"Pregnancy, Primary aldosteronism, and adrenal CTNNB1 mutations","volume":"373","author":"Teo","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.eprac.2021.01.007_bib13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41422-018-0019-5","article-title":"Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types","volume":"28","author":"Cao","year":"2018","journal-title":"Cell Res"},{"issue":"5","key":"10.1016\/j.eprac.2021.01.007_bib14","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.eprac.2021.01.007_bib15","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline","volume":"93","author":"Funder","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.eprac.2021.01.007_bib16","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1210\/jc.2014-3551","article-title":"Diagnostic value of ACTH stimulation test in determining the subtypes of primary aldosteronism","volume":"100","author":"Jiang","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/ERC-12-0022","article-title":"KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome","volume":"19","author":"Xekouki","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"10.1016\/j.eprac.2021.01.007_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1507\/endocrj.EJ16-0243","article-title":"Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations","volume":"64","author":"Okamura","year":"2017","journal-title":"Endocr J"},{"issue":"8","key":"10.1016\/j.eprac.2021.01.007_bib20","doi-asserted-by":"crossref","first-page":"E1089","DOI":"10.1210\/jc.2015-2149","article-title":"A\u00a0meta-analysis of somatic KCNJ5 K(+) channel mutations in 1636 patients with an aldosterone-producing adenoma","volume":"100","author":"Lenzini","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib21","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/HYPERTENSIONAHA.114.03346","article-title":"Clinical characteristics of somatic mutations in Chinese patients with aldosterone-producing adenoma","volume":"65","author":"Zheng","year":"2015","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.eprac.2021.01.007_bib22","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/HYPERTENSIONAHA.118.12064","article-title":"18-Oxocortisol synthesis in aldosterone-producing adrenocortical adenoma and significance of KCNJ5 mutation status","volume":"73","author":"Tezuka","year":"2019","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.eprac.2021.01.007_bib23","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1210\/jc.2018-01004","article-title":"Targeted molecular characterization of aldosterone-producing adenomas in white Americans","volume":"103","author":"Nanba","year":"2018","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.eprac.2021.01.007_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/joim.12831","article-title":"Diagnosis and treatment of primary aldosteronism: practical clinical perspectives","volume":"285","author":"Young","year":"2019","journal-title":"J\u00a0Intern Med"},{"issue":"6","key":"10.1016\/j.eprac.2021.01.007_bib25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00423-013-1093-2","article-title":"Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from western Norway","volume":"398","author":"Arnesen","year":"2013","journal-title":"Langenbecks Arch Surg"},{"issue":"4","key":"10.1016\/j.eprac.2021.01.007_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/ans.12470","article-title":"Mutations in KCNJ5 determines presentation and likelihood of cure in primary hyperaldosteronism","volume":"85","author":"Ip","year":"2015","journal-title":"ANZ J Surg"},{"issue":"3","key":"10.1016\/j.eprac.2021.01.007_bib27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/HJH.0000000000001578","article-title":"KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma","volume":"36","author":"Kitamoto","year":"2018","journal-title":"J\u00a0Hypertens"},{"issue":"10","key":"10.1016\/j.eprac.2021.01.007_bib28","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 somatic mutation is a predictor of hypertension remission after adrenalectomy for unilateral primary aldosteronism","volume":"104","author":"Vilela","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.eprac.2021.01.007_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2213-8587(16)30100-0","article-title":"Adrenal vein sampling versus CT scan to determine treatment in primary aldosteronism: an outcome-based randomised diagnostic trial","volume":"4","author":"Dekkers","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.eprac.2021.01.007_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.119.14341","article-title":"Precise mapping of intra-adrenal aldosterone activities provides a novel surgical strategy for primary aldosteronism","author":"Kitamoto","year":"2020","journal-title":"Hypertension"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X21000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X21000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:10:35Z","timestamp":1761516635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X21000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1530891X21000124"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2021.01.007","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KCNJ5 Mutation Contributes to Complete Clinical Success in Aldosterone-Producing Adenoma: A Study From a Single Center","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2021.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 AACE. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}