{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:18:30Z","timestamp":1766067510255,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["01158\/17"],"award-info":[{"award-number":["01158\/17"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.eprac.2022.02.010","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:59:15Z","timestamp":1646222355000},"page":"509-514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Importance of Periodical Screening for Primary Hyperparathyroidism in a Pituitary Tumor Cohort in Searching Patients With MEN1 and Its Genetic Profile"],"prefix":"10.1016","volume":"28","author":[{"given":"Sabrina S.P.","family":"Damianse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-4372","authenticated-orcid":false,"given":"Gilvan C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane C.C.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Gis\u00e9lia P.A. C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja C.","family":"Gaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana S.S.","family":"Azulay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wellyandra C.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandilson P.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Rosa P.","family":"Quidute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-668X","authenticated-orcid":false,"given":"Manuel","family":"dos S. Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.eprac.2022.02.010_bib1","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","author":"Thakker","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.eprac.2022.02.010_bib2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1590\/S0004-27302005000500014","article-title":"Multiple endocrine neoplasia type 1 (MEN 1): clinical, biochemical and molecular diagnosis and treatment of the associated disturbances. Article in Portuguese","volume":"49","author":"Hoff","year":"2005","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"3","key":"10.1016\/j.eprac.2022.02.010_bib3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/jc.2018-01170","article-title":"UMD-MEN1 Database: an overview of the 370 MEN1 variants present in 1676 patients from the French population","volume":"104","author":"Romanet","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1210\/jcem.87.2.8145","article-title":"Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study","volume":"87","author":"Verg\u00e8s","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2-3","key":"10.1016\/j.eprac.2022.02.010_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ando.2006.11.003","article-title":"Observatoire francophone des n\u00e9oplasies endocriniennes multiples de type 1. Un outil du Groupe d'\u00e9tude des Tumeurs Endocrines (GTE)","volume":"68","author":"Goudet","year":"2007","journal-title":"Ann Endocrinol (Paris)"},{"issue":"9","key":"10.1016\/j.eprac.2022.02.010_bib6","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1210\/JC.2015-2015","article-title":"Long-term natural course of pituitary tumors in patients with MEN1: results from the dutchmen1 study group (DMSG)","volume":"100","author":"de Laat","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.eprac.2022.02.010_bib7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2265.2007.02934.x","article-title":"Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers","volume":"67","author":"Machens","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5311","key":"10.1016\/j.eprac.2022.02.010_bib8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.eprac.2022.02.010_bib9","doi-asserted-by":"crossref","first-page":"T119","DOI":"10.1530\/ERC-17-0199","article-title":"The future: genetics advances in MEN1 therapeutic approaches and management strategies","volume":"24","author":"Agarwal","year":"2017","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"10.1016\/j.eprac.2022.02.010_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.20605","article-title":"Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene","volume":"29","author":"Lemos","year":"2008","journal-title":"Hum Mutat"},{"issue":"1","key":"10.1016\/j.eprac.2022.02.010_bib11","doi-asserted-by":"crossref","first-page":"E1089","DOI":"10.1002\/humu.21170","article-title":"Diagnostic challenges due to phenocopies: lessons from multiple endocrine neoplasia type1 (MEN1)","volume":"31","author":"Turner","year":"2010","journal-title":"Hum Mutat"},{"issue":"42","key":"10.1016\/j.eprac.2022.02.010_bib12","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0603877103","article-title":"Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans","volume":"103","author":"Pellegata","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2265.2008.03379.x","article-title":"Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neoplasia (MEN1) syndrome patients without any detectable MEN1 gene mutations","volume":"70","author":"Igreja","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"10.1016\/j.eprac.2022.02.010_bib14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2265.2011.04269.x","article-title":"Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain","volume":"76","author":"Belar","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1-2","key":"10.1016\/j.eprac.2022.02.010_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cancergen.2015.12.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1): an update of 208 new germline variants reported in the last nine years","volume":"209","author":"Concolino","year":"2016","journal-title":"Cancer Genet"},{"key":"10.1016\/j.eprac.2022.02.010_bib16","doi-asserted-by":"crossref","DOI":"10.1177\/1177271918785129","article-title":"Multiple endocrine neoplasia syndromes from genetic and epigenetic perspectives","volume":"13","author":"Khatami","year":"2018","journal-title":"Biomark Insights"},{"issue":"9","key":"10.1016\/j.eprac.2022.02.010_bib17","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1210\/jc.2019-00082","article-title":"Clinical features of multiple endocrine neoplasia type 4: novel pathogenic variant and review of published cases","volume":"104","author":"Frederiksen","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.eprac.2022.02.010_bib18","doi-asserted-by":"crossref","first-page":"e2271","DOI":"10.1210\/clinem\/dgaa142","article-title":"Clinical MEN-1 among a large cohort of patients with acromegaly","volume":"105","author":"Nachtigall","year":"2020","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.eprac.2022.02.010_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11102-013-0462-8","article-title":"Frequency of multiple endocrine neoplasia type 1 in a group of patients with pituitary adenoma: genetic study and familial screening","volume":"17","author":"Nunes","year":"2014","journal-title":"Pituitary"},{"key":"10.1016\/j.eprac.2022.02.010_bib20","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7230.1","article-title":"Genetics of multiple endocrine neoplasia type 1 syndrome: what\u2019s new and what\u2019s old","volume":"6","author":"Falchetti","year":"2017","journal-title":"F1000Res"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00268-009-0290-1","article-title":"Risk factors and causes of death in MEN1 disease. A GTE (Groupe d'Etude des Tumeurs Endocrines) cohort study among 758 patients","volume":"34","author":"Goudet","year":"2010","journal-title":"World J Surg"},{"issue":"3","key":"10.1016\/j.eprac.2022.02.010_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ando.2015.04.002","article-title":"Management of clinically non-functioning pituitary adenoma","volume":"76","author":"Chanson","year":"2015","journal-title":"Ann Endocrinol (Paris)"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/jc.2010-1692","article-title":"Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline","volume":"96","author":"Melmed","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.eprac.2022.02.010_bib24","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing\u2019s syndrome: an Endocrine Society Clinical Practice Guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.eprac.2022.02.010_bib25","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.eprac.2022.02.010_bib26","doi-asserted-by":"crossref","first-page":"E701","DOI":"10.1210\/jc.2010-1338","article-title":"Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas","volume":"96","author":"Costa-Guda","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5777","key":"10.1016\/j.eprac.2022.02.010_bib27","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","author":"Vierimaa","year":"2006","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.eprac.2022.02.010_bib28","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s40618-017-0725-8","article-title":"Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic","volume":"40","author":"Marques","year":"2017","journal-title":"J\u00a0Endocrinol Invest"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12020-017-1234-4","article-title":"Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database","volume":"58","author":"Giusti","year":"2017","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.eprac.2022.02.010_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41574-021-00468-3","article-title":"Clinical aspects of multiple endocrine neoplasia type 1","volume":"17","author":"Al-Salameh","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib31","first-page":"323","article-title":"Diferen\u00e7as sexo-espec\u00edficas na preval\u00eancia e nos fatores associados \u00e0 procura por servi\u00e7os de sa\u00fade em estudo epidemiol\u00f3gico de base populacional. Article in Portugese","volume":"17","author":"de Moraes","year":"2014","journal-title":"Rev Bras Epidemiol"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/endrev\/bnaa031","article-title":"Multiple endocrine neoplasia type 1: latest insights","volume":"42","author":"Brandi","year":"2021","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11102-019-00939-x","article-title":"Pituitary adenomas in patients with multiple endocrine neoplasia type 1: a single-center experience in China","volume":"22","author":"Wu","year":"2019","journal-title":"Pituitary"},{"issue":"4","key":"10.1016\/j.eprac.2022.02.010_bib34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAS.0b013e31815ade45","article-title":"Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients","volume":"32","author":"Trouillas","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.eprac.2022.02.010_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMc1406028","article-title":"Breast-cancer predisposition in multiple endocrine neoplasia type 1","volume":"371","author":"Dreijerink","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.eprac.2022.02.010_bib36","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1365-2796.2003.01164.x","article-title":"The treatment of sporadic versus MEN1-related pituitary adenomas","volume":"253","author":"Beckers","year":"2003","journal-title":"J\u00a0Intern Med"},{"issue":"10","key":"10.1016\/j.eprac.2022.02.010_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186485","article-title":"Mutational and large deletion study of genes implicated in hereditary forms of primary hyperparathyroidism and correlation with clinical features","volume":"12","author":"Pardi","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.eprac.2022.02.010_bib38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1","volume":"62","author":"Bassett","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.eprac.2022.02.010_bib39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1530\/ERC-13-0486","article-title":"p27 variant and corticotropinoma susceptibility: a genetic and in\u00a0vitro study","volume":"21","author":"Sekiya","year":"2014","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"10.1016\/j.eprac.2022.02.010_bib40","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1210\/jc.2006-2394","article-title":"Germline mutation in the aryl hydrocarbon receptor interacting protein gene in familial somatotropinoma","volume":"92","author":"Toledo","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.eprac.2022.02.010_bib41","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/jc.2006-2702","article-title":"Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas","volume":"92","author":"Barlier","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.eprac.2022.02.010_bib42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12020-021-02633-0","article-title":"The clinical aspects of pituitary tumour genetics","volume":"71","author":"D\u00e9nes","year":"2021","journal-title":"Endocrine"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22000659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22000659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:12:37Z","timestamp":1761516757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X22000659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1530891X22000659"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2022.02.010","relation":{},"ISSN":["1530-891X"],"issn-type":[{"type":"print","value":"1530-891X"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Importance of Periodical Screening for Primary Hyperparathyroidism in a Pituitary Tumor Cohort in Searching Patients With MEN1 and Its Genetic Profile","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2022.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 AACE. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}