{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:53:45Z","timestamp":1790052825596,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007427","name":"Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences","doi-asserted-by":"publisher","award":["22198-1"],"award-info":[{"award-number":["22198-1"]}],"id":[{"id":"10.13039\/501100007427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.eprac.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T01:24:06Z","timestamp":1659835446000},"page":"1140-1145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Time to Normalization and Sustainable Normal Serum Thyrotropin Concentrations in Patients with Hyperthyroidism: Comparison of Methimazole and Radioactive Iodine Treatments"],"prefix":"10.1016","volume":"28","author":[{"given":"Fereidoun","family":"Azizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Saadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengameh","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-7419","authenticated-orcid":false,"given":"Ladan","family":"Mehran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safdar","family":"Masoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Alireza","family":"Takyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-9408","authenticated-orcid":false,"given":"Atieh","family":"Amouzegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.eprac.2022.08.004_bib1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1510030","article-title":"Graves\u2019 disease","volume":"375","author":"Smith","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.eprac.2022.08.004_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrendo.2010.105","article-title":"Cardiovascular involvement in patients with different causes of hyperthyroidism","volume":"6","author":"Biondi","year":"2010","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.eprac.2022.08.004_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1530\/EJE-13-0708","article-title":"Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study","volume":"170","author":"Brandt","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/eje.0.1510549","article-title":"Impaired health-related quality of life in Graves\u2019 disease. A prospective study","volume":"151","author":"Elberling","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.eprac.2022.08.004_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/105072503322238854","article-title":"Hyperthyroidism, bone mineral, and fracture risk\u2014a meta-analysis","volume":"13","author":"Vestergaard","year":"2003","journal-title":"Thyroid"},{"issue":"10","key":"10.1016\/j.eprac.2022.08.004_bib6","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"6","key":"10.1016\/j.eprac.2022.08.004_bib7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1530\/EJE-20-1490","article-title":"Preferences of patients and clinicians for treatment of Graves\u2019 disease: a discrete choice experiment","volume":"184","author":"van Kinschot","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.eprac.2022.08.004_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/thy.2019.0132","article-title":"Patterns of use, efficacy, and safety of treatment options for patients with Graves\u2019 disease: a nationwide population-based study","volume":"30","author":"Brito","year":"2020","journal-title":"Thyroid"},{"issue":"10","key":"10.1016\/j.eprac.2022.08.004_bib9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/thy.2016.0652","article-title":"Long-term antithyroid drug treatment: a systematic review and meta-analysis","volume":"27","author":"Azizi","year":"2017","journal-title":"Thyroid"},{"issue":"9","key":"10.1016\/j.eprac.2022.08.004_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1089\/thy.2019.0180","article-title":"Increased remission rates after long-term methimazole therapy in patients with Graves\u2019 disease: results of a randomized clinical trial","volume":"29","author":"Azizi","year":"2019","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/MED.0000000000000656","article-title":"Long-term antithyroid drug therapy","volume":"28","author":"Cooper","year":"2021","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"4","key":"10.1016\/j.eprac.2022.08.004_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000490384","article-title":"2018 European Thyroid Association guideline for the management of Graves\u2019 hyperthyroidism","volume":"7","author":"Kahaly","year":"2018","journal-title":"Europ Thyroid J"},{"issue":"7","key":"10.1016\/j.eprac.2022.08.004_bib13","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1210\/jc.2017-00166","article-title":"Excess mortality in treated and untreated hyperthyroidism is related to cumulative periods of low serum TSH","volume":"102","author":"Lillevang-Johansen","year":"2017","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.eprac.2022.08.004_bib14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/thy.2018.0320","article-title":"Duration of hyperthyroidism and lack of sufficient treatment are associated with increased cardiovascular risk","volume":"29","author":"Lillevang-Johansen","year":"2019","journal-title":"Thyroid"},{"issue":"8","key":"10.1016\/j.eprac.2022.08.004_bib15","article-title":"Long-term continuous methimazole or radioiodine treatment for hyperthyroidism","volume":"15","author":"Azizi","year":"2012","journal-title":"Arch Iran Med"},{"issue":"4","key":"10.1016\/j.eprac.2022.08.004_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/thy.2011.0156","article-title":"Eighteen years of continuously sustained elimination of iodine deficiency in the Islamic Republic of Iran: the vitality of periodic monitoring","volume":"22","author":"Delshad","year":"2012","journal-title":"Thyroid"},{"issue":"11","key":"10.1016\/j.eprac.2022.08.004_bib17","first-page":"950","article-title":"Reference limit of thyrotropin (TSH) and free thyroxine (FT4) in thyroperoxidase positive and negative subjects: a population based study","volume":"36","author":"Amouzegar","year":"2013","journal-title":"J\u00a0Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.eprac.2022.08.004_bib18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/thy.2012.0500","article-title":"Graves\u2019 disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study","volume":"23","author":"Brandt","year":"2013","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib19","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2012-3459","article-title":"Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine","volume":"98","author":"Boelaert","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.eprac.2022.08.004_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S2213-8587(19)30059-2","article-title":"Primary therapy of Graves\u2019 disease and cardiovascular morbidity and mortality: a linked-record cohort study","volume":"7","author":"Okosieme","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/ct.2019;31.185-188","article-title":"Long-term methimazole is as effective as radioiodine therapy for the treatment of toxic multinodular goiter","volume":"31","author":"Ganji","year":"2019","journal-title":"Clin Thyroidol"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1530\/eje.1.01904","article-title":"Effect of long-term continuous methimazole treatment of hyperthyroidism: comparison with radioiodine","volume":"152","author":"Azizi","year":"2005","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.eprac.2022.08.004_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/cen.14374","article-title":"Comparison of long-term antithyroid drugs versus radioactive iodine or surgery for Graves\u2019 disease: a review of the literature","volume":"95","author":"El Kawkgi","year":"2021","journal-title":"Clin Endocrinol"},{"issue":"12","key":"10.1016\/j.eprac.2022.08.004_bib24","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1089\/thy.2015.0195","article-title":"Outcomes in relapsed Graves\u2019 disease patients following radioiodine or prolonged low dose of methimazole treatment","volume":"25","author":"Villagelin","year":"2015","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.eprac.2022.08.004_bib25","doi-asserted-by":"crossref","first-page":"e95385","DOI":"10.5812\/ijem.95385","article-title":"Systemic thyroid hormone status in treated Graves\u2019 disease","volume":"17","author":"Azizi","year":"2019","journal-title":"Int J Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.eprac.2022.08.004_bib26","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1210\/jc.2016-2660","article-title":"Is a normal TSH synonymous with \u201ceuthyroidism\u201d in levothyroxine monotherapy?","volume":"101","author":"Peterson","year":"2016","journal-title":"J\u00a0Clinl Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000512734","article-title":"Metabolic changes after radioiodine correction of grade 1 and grade 2 subclinical hyperthyroidism","volume":"10","author":"Russo","year":"2021","journal-title":"Eur Thyroid J"},{"issue":"3","key":"10.1016\/j.eprac.2022.08.004_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/thy.2015.0345","article-title":"Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition","volume":"26","author":"Samuels","year":"2016","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.eprac.2022.08.004_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2265.2002.01654.x","article-title":"Psychological well-being in patients on \u2018adequate\u2019 doses of l-thyroxine: results of a large, controlled community-based questionnaire study","volume":"57","author":"Saravanan","year":"2002","journal-title":"Clin Endocrinol"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22005791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22005791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:13:21Z","timestamp":1761516801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X22005791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1530891X22005791"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2022.08.004","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time to Normalization and Sustainable Normal Serum Thyrotropin Concentrations in Patients with Hyperthyroidism: Comparison of Methimazole and Radioactive Iodine Treatments","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2022.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 AACE. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}