{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:23:12Z","timestamp":1788276192447,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015077","name":"Jagiellonian University in Krak\u00f3w Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.eprac.2022.12.015","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T19:47:04Z","timestamp":1672084024000},"page":"174-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient\u2019s Examination and Retraining on Change of Infusion Set"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8767-403X","authenticated-orcid":false,"given":"Damian","family":"Ucieklak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mrozi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Wojnarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej T.","family":"Ma\u0142ecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Klupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-352X","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Matejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10138","key":"10.1016\/j.eprac.2022.12.015_bib1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","article-title":"Type 1 diabetes","volume":"391","author":"DiMeglio","year":"2018","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.eprac.2022.12.015_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jdiacomp.2018.05.007","article-title":"What are the clinical, quality-of-life, and cost consequences of 30 years of excellent vs. poor glycemic control in type 1 diabetes?","volume":"32","author":"Herman","year":"2018","journal-title":"J\u00a0Diabetes Complications"},{"key":"10.1016\/j.eprac.2022.12.015_bib3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3389\/fendo.2018.00638","article-title":"Insulin-related lipohypertrophy: lipogenic action or tissue trauma?","volume":"9","author":"Barola","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6230","key":"10.1016\/j.eprac.2022.12.015_bib4","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1136\/bmj.280.6230.1500","article-title":"Insulin-induced lipoatrophy: evidence for an immune pathogenesis","volume":"280","author":"Reeves","year":"1980","journal-title":"Br Med J"},{"issue":"8","key":"10.1016\/j.eprac.2022.12.015_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1055\/s-2001-18991","article-title":"Insulin antibodies are associated with lipoatrophy but also with lipohypertrophy in children and adolescents with type 1 diabetes","volume":"109","author":"Raile","year":"2001","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"2","key":"10.1016\/j.eprac.2022.12.015_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13300-016-0161-3","article-title":"Frequency of lipohypertrophy and associated risk factors in young patients with type 1 diabetes: a cross-sectional study","volume":"7","author":"Al Hayek","year":"2016","journal-title":"Diabetes Ther"},{"issue":"1","key":"10.1016\/j.eprac.2022.12.015_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00592-017-1066-y","article-title":"Errors in insulin treatment management and risk of lipohypertrophy","volume":"55","author":"Pozzuoli","year":"2018","journal-title":"Acta Diabetol"},{"issue":"5","key":"10.1016\/j.eprac.2022.12.015_bib8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.diabet.2013.05.006","article-title":"Prevalence and risk factors of lipohypertrophy in insulin-injecting patients with diabetes","volume":"39","author":"Blanco","year":"2013","journal-title":"Diabetes Metab"},{"issue":"2","key":"10.1016\/j.eprac.2022.12.015_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.diabres.2006.12.023","article-title":"Incidence of lipohypertrophy in diabetic patients and a study of influencing factors","volume":"77","author":"Vardar","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"10.1016\/j.eprac.2022.12.015_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3897\/folmed.62.e50166","article-title":"Insulin-induced lipoatrophy in a patient on insulin analogue therapy: a case report","volume":"62","author":"Yanachkova","year":"2020","journal-title":"Folia Med (Plovdiv)"},{"issue":"10","key":"10.1016\/j.eprac.2022.12.015_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/00128071-200304100-00001","article-title":"Skin-related complications of insulin therapy: epidemiology and emerging management strategies","volume":"4","author":"Richardson","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.eprac.2022.12.015_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9169296","article-title":"Insulin-induced lipohypertrophy in patients with type 1 diabetes mellitus treated with an insulin pump","volume":"2022","author":"Ucieklak","year":"2022","journal-title":"Int J Endocrinol"},{"issue":"5","key":"10.1016\/j.eprac.2022.12.015_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2337\/diacare.7.5.479","article-title":"Diabetic lipohypertrophy delays insulin absorption","volume":"7","author":"Young","year":"1984","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.eprac.2022.12.015_bib14","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.2337\/dc16-0610","article-title":"Insulin injection into lipohypertrophic tissue: blunted and more variable insulin absorption and action and impaired postprandial glucose control","volume":"39","author":"Famulla","year":"2016","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.eprac.2022.12.015_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107806","article-title":"Subclinical lipohypertrophy--easily ignored complications of insulin therapy","volume":"35","author":"Luo","year":"2021","journal-title":"J\u00a0Diabetes Complications"},{"issue":"7","key":"10.1016\/j.eprac.2022.12.015_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/dia.2018.0074","article-title":"Clinical implications of lipohypertrophy among people with type 1 diabetes in India","volume":"20","author":"Gupta","year":"2018","journal-title":"Diabetes Technol Ther"},{"issue":"9","key":"10.1016\/j.eprac.2022.12.015_bib17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.mayocp.2016.06.010","article-title":"New insulin delivery recommendations","volume":"91","author":"Frid","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.eprac.2022.12.015_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/s40064-016-1978-y","article-title":"A\u00a0suitable palpation technique allows to identify skin lipohypertrophic lesions in insulin-treated people with diabetes","volume":"5","author":"Gentile","year":"2016","journal-title":"Springerplus"},{"issue":"10","key":"10.1016\/j.eprac.2022.12.015_bib19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s40618-017-0675-1","article-title":"Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus","volume":"40","author":"Bertuzzi","year":"2017","journal-title":"J\u00a0Endocrinol Invest"},{"issue":"29","key":"10.1016\/j.eprac.2022.12.015_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026743","article-title":"Values of ultrasound for diagnosis and management of insulin-induced lipohypertrophy: a prospective cohort study in China","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.eprac.2022.12.015_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-055529","article-title":"Efficacy of education on injection technique for patients diagnosed with diabetes with lipohypertrophy: systematic review and meta-analysis","volume":"12","author":"Ichikawa","year":"2022","journal-title":"BMJ Open"},{"issue":"10","key":"10.1016\/j.eprac.2022.12.015_bib22","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/dme.13764","article-title":"Ultrasound detection of insulin-induced lipohypertrophy in type 1 and type 2 diabetes","volume":"35","author":"Kapeluto","year":"2018","journal-title":"Diabet Med"},{"issue":"5","key":"10.1016\/j.eprac.2022.12.015_bib23","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s13300-018-0472-7","article-title":"A\u00a0systematic review of ultrasound-detected lipohypertrophy in insulin-exposed people with diabetes","volume":"9","author":"Abu Ghazaleh","year":"2018","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.eprac.2022.12.015_bib24","article-title":"Praktyczne wskaz\u00f3wki w leczeniu cukrzycy u os\u00f3b doros\u0142ych za pomoca osobistej pompy insulinowej","volume":"2","author":"Gawrecki","year":"2015","journal-title":"Via Medica. Gdansk"},{"issue":"1","key":"10.1016\/j.eprac.2022.12.015_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.17140\/DROJ-2-126","article-title":"Unexplained hypoglycaemia and large glycaemic variability: skin lipohypertrophy as a predictive sign","volume":"2","author":"Strollo","year":"2016","journal-title":"Diabetes Res Open J"},{"issue":"2","key":"10.1016\/j.eprac.2022.12.015_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00592-009-0172-x","article-title":"Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes","volume":"48","author":"Gentile","year":"2011","journal-title":"Acta Diabetol"},{"issue":"1","key":"10.1016\/j.eprac.2022.12.015_bib28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13300-018-0561-7","article-title":"Impact of insulin injection and infusion routines on lipohypertrophy and glycemic control in children and adults with diabetes","volume":"10","author":"Deeb","year":"2019","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.eprac.2022.12.015_bib29","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.2147\/DMSO.S282926","article-title":"Prevalence, risk factors, and clinical characteristics of lipodystrophy in insulin-treated patients with diabetes: an old problem in a new era of modern insulin","volume":"13","author":"Thewjitcharoen","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"4","key":"10.1016\/j.eprac.2022.12.015_bib30","first-page":"145","article-title":"Optimizing insulin injection technique and its effect on blood glucose control","volume":"1","author":"Grassi","year":"2014","journal-title":"J\u00a0Clin Transl Endocrinol"},{"issue":"4","key":"10.1016\/j.eprac.2022.12.015_bib31","first-page":"62","article-title":"Clinical significance of lipohypertrophy without\u00a0visual and palpable changes detected by ultrasonography of subcutaneous fat","volume":"91","author":"Volkova","year":"2019","journal-title":"Ter Arkh"},{"issue":"1","key":"10.1016\/j.eprac.2022.12.015_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/dme.14672","article-title":"Lipohypertrophy Monitoring Study (LIMO): Effect of single use of 4 mm pen needles combined with education on injection site rotation on glycaemic control: confirmation of an unpleasant truth","volume":"39","author":"Bochanen","year":"2022","journal-title":"Diabet Med"},{"issue":"5","key":"10.1016\/j.eprac.2022.12.015_bib33","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s13300-021-01006-0","article-title":"Role of structured education in reducing lypodistrophy and its metabolic complications in insulin-treated people with type 2 diabetes: a randomized multicenter case-control study","volume":"12","author":"Gentile","year":"2021","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.eprac.2022.12.015_bib34","doi-asserted-by":"crossref","unstructured":"Chen L, Xing Q, Li J, et\u00a0al. Injection technique education in patients with diabetes injecting insulin into areas of lipohypertrophy: a randomized controlled trial. Diabetes Ther. 2021;12(3):813-826. doi:10.1007\/s13300-021-01013-1. Published correction appears in Diabetes Ther. 2021;12(6):1763-1764.","DOI":"10.1007\/s13300-021-01057-3"},{"issue":"11","key":"10.1016\/j.eprac.2022.12.015_bib35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/dia.2017.0165","article-title":"An effective intervention for diabetic lipohypertrophy: results of a randomized, controlled, prospective multicenter study in France","volume":"19","author":"Campinos","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.1016\/j.eprac.2022.12.015_bib36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.diabres.2018.07.030","article-title":"Cost saving effects of a short-term educational intervention entailing lower hypoglycaemic event rates in people with type 1 diabetes and lipo-hypertrophy","volume":"143","author":"Gentile","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.eprac.2022.12.015_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.diabres.2017.01.020","article-title":"UK lipohypertrophy interventional study","volume":"126","author":"Smith","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"10.1016\/j.eprac.2022.12.015_bib38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/1932296819888213","article-title":"Lipohypertrophy effect on glycemic profile in an adult with type 1 diabetes using scanned continuous glucose monitoring","volume":"14","author":"Oriot","year":"2020","journal-title":"J\u00a0Diabetes Sci Technol"},{"issue":"9","key":"10.1016\/j.eprac.2022.12.015_bib39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/dia.2016.07281.sf","article-title":"Insulin infusion set use: European perspectives and recommendations","volume":"18","author":"Deiss","year":"2016","journal-title":"Diabetes Technol Ther"},{"issue":"6","key":"10.1016\/j.eprac.2022.12.015_bib40","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2337\/diacare.16.6.929","article-title":"Severe insulin-induced lipohypertrophy successfully treated by liposuction","volume":"16","author":"Hardy","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.eprac.2022.12.015_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108534","article-title":"How to treat improper insulin injection-related lipohypertrophy: a 3-year follow-up of a monster case and an update on treatment","volume":"171","author":"Gentile","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"10.1016\/j.eprac.2022.12.015_bib42","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.dsx.2019.01.033","article-title":"AMD-OSDI Study Group on Injection Technique. Lessons learned from an unusual case of severe hypoglycemia","volume":"13","author":"Improta","year":"2019","journal-title":"Diabetes Metab Syndr"},{"issue":"8","key":"10.1016\/j.eprac.2022.12.015_bib43","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2337\/dci19-0028","article-title":"Clinical targets for continuous glucose monitoring data interpretation: recommendations from the International consensus on time in range","volume":"42","author":"Battelino","year":"2019","journal-title":"Diabetes Care"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22009077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X22009077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:13:54Z","timestamp":1761516834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X22009077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1530891X22009077"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2022.12.015","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient\u2019s Examination and Retraining on Change of Infusion Set","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2022.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 AACE. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}