{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:06:18Z","timestamp":1791515178382,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.eprac.2023.06.013","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:59:57Z","timestamp":1692583197000},"page":"862-867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Metformin Use on Vitamin B12 Deficiency Over Time (EMBER): A Real-World Evidence Database Study"],"prefix":"10.1016","volume":"29","author":[{"given":"Keri","family":"Hurley-Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuong Hoang","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhat Minh","family":"Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam Chau","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McBane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryana","family":"Sepassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.eprac.2023.06.013_bib5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s40261-019-00799-0","article-title":"Emerging trends in metformin prescribing in the United States from 2000 to 2015","volume":"39","author":"Le","year":"2019","journal-title":"Clin Drug Investig"},{"issue":"2","key":"10.1016\/j.eprac.2023.06.013_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/ph14020122","article-title":"The current and potential therapeutic use of metformin-the good old drug","volume":"14","author":"Drzewoski","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1-2","key":"10.1016\/j.eprac.2023.06.013_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00508-016-1135-1","article-title":"Prescription of oral antidiabetic drugs in Tyrol - data from the Tyrol diabetes registry 2012-2015","volume":"129","author":"Lunger","year":"2016","journal-title":"Wien Klin Wochenschr"},{"issue":"4","key":"10.1016\/j.eprac.2023.06.013_bib10","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1210\/jc.2015-3754","article-title":"Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study","volume":"101","author":"Aroda","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.eprac.2023.06.013_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40360-016-0088-3","article-title":"Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy","volume":"17","author":"Ahmed","year":"2016","journal-title":"BMC Pharmacol Toxicol"},{"issue":"5","key":"10.1016\/j.eprac.2023.06.013_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.diabet.2016.03.008","article-title":"Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"42","author":"Chapman","year":"2016","journal-title":"Diabetes Metab"},{"issue":"7","key":"10.1016\/j.eprac.2023.06.013_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4239\/wjd.v12.i7.916","article-title":"Long-term metformin therapy and vitamin B12 deficiency: an association to bear in mind","volume":"12","author":"Infante","year":"2021","journal-title":"World J Diabetes"},{"issue":"1","key":"10.1016\/j.eprac.2023.06.013_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/bmjnph-2020-000193","article-title":"Assessment of vitamin B12 deficiency and B12 screening trends for patients on metformin: a retrospective cohort case review","volume":"4","author":"Martin","year":"2021","journal-title":"BMJ Nutr Prev Health"},{"issue":"9","key":"10.1016\/j.eprac.2023.06.013_bib15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00592-020-01526-4","article-title":"Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus","volume":"57","author":"Shivaprasad","year":"2020","journal-title":"Acta Diabetol"},{"issue":"9","key":"10.1016\/j.eprac.2023.06.013_bib16","first-page":"729","article-title":"Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis","volume":"11","author":"Yang","year":"2019","journal-title":"J\u00a0Diabetes"},{"issue":"46","key":"10.1016\/j.eprac.2023.06.013_bib17","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017918","article-title":"Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.eprac.2023.06.013_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.amjms.2017.04.010","article-title":"Metformin use and vitamin B12 deficiency: untangling the association","volume":"354","author":"Rodr\u00edguez-Guti\u00e9rrez","year":"2017","journal-title":"Am J Med Sci"},{"issue":"3","key":"10.1016\/j.eprac.2023.06.013_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.18433\/J3PK7P","article-title":"Metformin and vitamin B12 deficiency: where do we stand?","volume":"19","author":"Ahmed","year":"2016","journal-title":"J\u00a0Pharm Pharm Sci"},{"issue":"8","key":"10.1016\/j.eprac.2023.06.013_bib20","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/dom.14734","article-title":"Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes","volume":"24","author":"Bell","year":"2022","journal-title":"Diabetes Obes Metab"},{"issue":"10","key":"10.1016\/j.eprac.2023.06.013_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of peripheral neuropathy and lower extremity disease in diabetes","volume":"19","author":"Hicks","year":"2019","journal-title":"Curr Diab Rep"},{"issue":"10","key":"10.1016\/j.eprac.2023.06.013_bib23","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.2337\/diacare.28.10.2378","article-title":"Diabetic peripheral neuropathy and depressive symptoms: the association revisited","volume":"28","author":"Vileikyte","year":"2005","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.eprac.2023.06.013_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/nu13020395","article-title":"Vitamin B12 supplementation in diabetic neuropathy: a 1-year, randomized, double-blind, placebo-controlled trial","volume":"13","author":"Didangelos","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.eprac.2023.06.013_bib25","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.2147\/DMSO.S237454","article-title":"Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels?","volume":"13","author":"Wakeman","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"7","key":"10.1016\/j.eprac.2023.06.013_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d Research Program","volume":"381","author":"Denny","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.eprac.2023.06.013_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/qjmed\/hct051","article-title":"The pathophysiology of elevated vitamin B12 in clinical practice","volume":"106","author":"Andr\u00e8s","year":"2013","journal-title":"QJM"},{"issue":"8","key":"10.1016\/j.eprac.2023.06.013_bib28","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1515\/cclm-2014-0784","article-title":"A\u00a0review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population","volume":"53","author":"Aparicio-Ugarriza","year":"2015","journal-title":"Clin Chem Lab Med"},{"issue":"11","key":"10.1016\/j.eprac.2023.06.013_bib29","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"key":"10.1016\/j.eprac.2023.06.013_bib30","series-title":"Positioning and Power in Academic Publishing: Players, Agents and Agendas: Proceedings of the 20th International Conference on Electronic Publishing","first-page":"87","article-title":"J.\u00a0Jupyter Notebooks - a publishing format for reproducible computational workflows","author":"Kluyver","year":"2016"},{"issue":"1","key":"10.1016\/j.eprac.2023.06.013_bib31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.nutr.19.1.357","article-title":"Vitamin B12 deficiency in the elderly","volume":"19","author":"Baik","year":"1999","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.eprac.2023.06.013_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.archger.2018.07.019","article-title":"Association of metformin use with vitamin B12 deficiency in the institutionalized elderly","volume":"79","author":"Wong","year":"2018","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.eprac.2023.06.013_bib33","doi-asserted-by":"crossref","first-page":"c2181","DOI":"10.1136\/bmj.c2181","article-title":"Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial","volume":"340","author":"de Jager","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.eprac.2023.06.013_bib34","author":"Ankar"}],"updated-by":[{"DOI":"10.1016\/j.eprac.2023.10.130","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000}}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X23005268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X23005268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T17:06:54Z","timestamp":1716311214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X23005268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1530891X23005268"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2023.06.013","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Metformin Use on Vitamin B12 Deficiency Over Time (EMBER): A Real-World Evidence Database Study","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2023.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 AACE. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}