{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:52:20Z","timestamp":1781319140292,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013070","name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.eprac.2024.09.009","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T06:20:03Z","timestamp":1726726803000},"page":"1158-1165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Causality of Hashimoto's Thyroiditis to Thyroid Cancer: A 2-S Mendelian Randomization Study"],"prefix":"10.1016","volume":"30","author":[{"given":"Xiaojie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafa","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eprac.2024.09.009_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.eprac.2024.09.009_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3389\/fimmu.2017.00521","article-title":"Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases","volume":"8","author":"Fr\u00f6hlich","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.eprac.2024.09.009_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.1020709","article-title":"Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: a systematic review and meta-analysis","volume":"10","author":"Hu","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.eprac.2024.09.009_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.579140","article-title":"Detection of alterations in the gut microbiota and intestinal permeability in patients with Hashimoto thyroiditis","volume":"12","author":"Cayres","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.eprac.2024.09.009_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/jamapsychiatry.2018.0190","article-title":"Association of depression and anxiety disorders with autoimmune thyroiditis: a systematic review and meta-analysis","volume":"75","author":"Siegmann","year":"2018","journal-title":"JAMA Psychiat"},{"key":"10.1016\/j.eprac.2024.09.009_bib6","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism","volume":"390","author":"Chaker","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.eprac.2024.09.009_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF03401282","article-title":"Hashimoto's thyroiditis: history and future outlook","volume":"12","author":"Hiromatsu","year":"2013","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.eprac.2024.09.009_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.eprac.2024.09.009_bib9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12020-020-02207-6","article-title":"Thyroid cancer: incidence and mortality trends in China, 2005-2015","volume":"68","author":"Wang","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.eprac.2024.09.009_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.31768\/2312-8852.2018.40(2):128-131","article-title":"Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties","volume":"40","author":"Myshunina","year":"2018","journal-title":"Exp Oncol"},{"key":"10.1016\/j.eprac.2024.09.009_bib11","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1089\/thy.2023.0052","article-title":"A\u00a0prospective multicenter study examining the relationship between thyroid cancer treatment outcomes and the presence of autoimmune thyroiditis","volume":"33","author":"De Leo","year":"2023","journal-title":"Thyroid"},{"key":"10.1016\/j.eprac.2024.09.009_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MED.0000000000000570","article-title":"Hashimoto's thyroiditis as a risk factor for thyroid cancer","volume":"27","author":"VFeldt-Rasmussen","year":"2020","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.eprac.2024.09.009_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/CCO.0000000000000150","article-title":"Association of Hashimoto's thyroiditis and thyroid cancer","volume":"27","author":"Noureldine","year":"2015","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.eprac.2024.09.009_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/0194599812472426","article-title":"Hashimoto's thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis","volume":"148","author":"Lun","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.eprac.2024.09.009_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jss.2007.09.020","article-title":"Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer?","volume":"150","author":"Repplinger","year":"2007","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.eprac.2024.09.009_bib16","article-title":"Cancer risk in Hashimoto's thyroiditis: a systematic review and meta-analysis","volume":"13","author":"Hu","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.eprac.2024.09.009_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15194902","article-title":"Hashimoto's thyroiditis and the risk of papillary thyroid cancer in children","volume":"15","author":"Gallant","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.eprac.2024.09.009_bib18","first-page":"286","article-title":"Inflammation in thyroid oncogenesis","volume":"2","author":"Liotti","year":"2012","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.eprac.2024.09.009_bib19","article-title":"Chronic inflammation and cytokines in the tumor microenvironment","author":"Landskron","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.eprac.2024.09.009_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jc.2012-2978","article-title":"Clinical Review: Hashimoto's thyroiditis and papillary thyroid carcinoma: is there a correlation?","volume":"98","author":"Jankovic","year":"2013","journal-title":"J\u00a0Clin Endocr Metab"},{"key":"10.1016\/j.eprac.2024.09.009_bib21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.18051\/UnivMed.2018.v37.216-221","article-title":"Hashimoto\u2019s thyroiditis is not a risk factor for thyroid cancer","volume":"37","author":"Eshraghi","year":"2018","journal-title":"Universa Med"},{"key":"10.1016\/j.eprac.2024.09.009_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0306-4603(94)90040-X","article-title":"A\u00a0longitudinal analysis of predictors of quitting smoking among participants in a self-help intervention trial","volume":"19","author":"Hill","year":"1994","journal-title":"Addict Behav"},{"key":"10.1016\/j.eprac.2024.09.009_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12890-023-02546-w","article-title":"Association between a single nucleotide polymorphism of the IL23R gene and tuberculosis in a Chinese Han population: a case\u2012control study","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.eprac.2024.09.009_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/mds.29337","article-title":"Investigation of shared genetic risk factors between Parkinson's disease and cancers","volume":"38","author":"Sugier","year":"2023","journal-title":"Mov Disord"},{"key":"10.1016\/j.eprac.2024.09.009_bib25","doi-asserted-by":"crossref","first-page":"105524","DOI":"10.1016\/j.meegid.2023.105524","article-title":"Assessing the association between the circulating levels of inflammatory cytokines and the risk of tuberculosis: a bidirectional two-sample mendelian randomization study","volume":"116","author":"Zhang","year":"2023","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.eprac.2024.09.009_bib26","doi-asserted-by":"crossref","first-page":"e2783","DOI":"10.1210\/clinem\/dgac196","article-title":"Appraising the effect of potential risk factors on thyroid cancer: a mendelian randomization study","volume":"107","author":"Huang","year":"2022","journal-title":"J\u00a0Clin Endocr Metab"},{"key":"10.1016\/j.eprac.2024.09.009_bib27","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1002\/cam4.3970","article-title":"The global burden of thyroid cancer and its attributable risk factor in 195 countries and territories: a systematic analysis for the Global Burden of Disease Study","volume":"10","author":"Zhai","year":"2021","journal-title":"Cancer Med"},{"key":"10.1016\/j.eprac.2024.09.009_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00004","article-title":"Correlation between Hashimoto's thyroiditis-related thyroid hormone levels and 25-hydroxyvitamin D","volume":"11","author":"Chao","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.eprac.2024.09.009_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/eurheartj\/ehad631","article-title":"Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association","volume":"45","author":"Ardissino","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eprac.2024.09.009_bib30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.eprac.2024.09.009_bib31","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ije\/dyy262","article-title":"An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings","volume":"48","author":"Sanderson","year":"2019","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.eprac.2024.09.009_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12916-023-02780-3","article-title":"Circulating levels of micronutrients and risk of infections: a Mendelian randomization study","volume":"21","author":"Flatby","year":"2023","journal-title":"BMC Med"},{"key":"10.1016\/j.eprac.2024.09.009_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.eprac.2024.09.009_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1530\/ERC-11-0028","article-title":"Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine","volume":"18","author":"Fiore","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.eprac.2024.09.009_bib35","first-page":"74","article-title":"Association between HASHIMOTO'S thyroiditis and papillary thyroid cancer: a single center experience","volume":"18","author":"Danis","year":"2022","journal-title":"Acta Endocrinol"},{"key":"10.1016\/j.eprac.2024.09.009_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/thy.2007.0234","article-title":"Changed presentation of Hashimoto's thyroiditis in north-eastern sicily and calabria (southern Italy) based on a 31-year experience","volume":"18","author":"Benvenga","year":"2008","journal-title":"Thyroid"},{"key":"10.1016\/j.eprac.2024.09.009_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/EJE-12-0903","article-title":"The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis","volume":"168","author":"Lee","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.eprac.2024.09.009_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2022.102273","article-title":"CARD9 gene rs4077515 polymorphism is associated with the susceptibility of Hashimoto's thyroiditis and the development of thyroid cancer","volume":"81","author":"Zhang","year":"2022","journal-title":"Cancer Epidemiol"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X2400675X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X2400675X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:38:45Z","timestamp":1733132325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X2400675X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1530891X2400675X"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2024.09.009","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causality of Hashimoto's Thyroiditis to Thyroid Cancer: A 2-S Mendelian Randomization Study","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2024.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 AACE. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}