{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:44:41Z","timestamp":1785840281770,"version":"3.56.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.eprac.2026.04.008","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:27:41Z","timestamp":1776526061000},"page":"1177-1184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Family History Predicts Primary Hyperparathyroidism Regardless of Genetic Predisposition"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-667X","authenticated-orcid":false,"given":"Reut","family":"Halperin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Tripto-Shkolnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Vered","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinchas","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Avior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Milloh-Raz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ilany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naama","family":"Peltz-Sinvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Cukierman-Yaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Lasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigal","family":"Ben-Shmuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Jabarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehudit","family":"Eden-Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Goldinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadi","family":"Shlomai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naama","family":"Peshes Yaloz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-9634","authenticated-orcid":false,"given":"Amit","family":"Tirosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.eprac.2026.04.008_bib1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/jbmr.4665","article-title":"Epidemiology, pathophysiology, and genetics of primary hyperparathyroidism","volume":"37","author":"Minisola","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"10","key":"10.1016\/j.eprac.2026.04.008_bib2","doi-asserted-by":"crossref","first-page":"e1117","DOI":"10.1210\/clinem\/dgad201","article-title":"Stable incidence and increasing prevalence of primary hyperparathyroidism in a population-based Study in Scotland","volume":"108","author":"Soto-Pedre","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.eprac.2026.04.008_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","article-title":"Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus","volume":"28","author":"Khan","year":"2017","journal-title":"Osteoporos Int"},{"issue":"5","key":"10.1016\/j.eprac.2026.04.008_bib4","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jamcollsurg.2018.01.007","article-title":"Probability of positive genetic testing results in patients with family history of primary hyperparathyroidism","volume":"226","author":"El Lakis","year":"2018","journal-title":"J Am Coll Surg"},{"issue":"20","key":"10.1016\/j.eprac.2026.04.008_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011206","article-title":"Parathyroid tumors: molecular signatures","volume":"22","author":"Marini","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.eprac.2026.04.008_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12020-021-02927-3","article-title":"A contemporary clinical approach to genetic testing for heritable hyperparathyroidism syndromes","volume":"75","author":"De Sousa","year":"2022","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.eprac.2026.04.008_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ando.2025.101694","article-title":"Chapter 5: the roles of genetics in primary hyperparathyroidism","volume":"86","author":"Romanet","year":"2025","journal-title":"Ann Endocrinol (Paris)"},{"issue":"8","key":"10.1016\/j.eprac.2026.04.008_bib8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S2213-8587(25)00119-6","article-title":"Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice","volume":"13","author":"Brandi","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"10.1016\/j.eprac.2026.04.008_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/diseases13040098","article-title":"An analysis of primary hyperparathyroidism in individuals diagnosed with multiple Endocrine Neoplasia type 2","volume":"13","author":"Gheorghe","year":"2025","journal-title":"Diseases"},{"issue":"9","key":"10.1016\/j.eprac.2026.04.008_bib10","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1210\/clinem\/dgaf089","article-title":"Approach to the patient: hereditary medullary thyroid carcinoma","volume":"110","author":"Shariq","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.eprac.2026.04.008_bib11","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-22-0174","article-title":"Germline CDKN1B variant type and site are associated with phenotype in MEN4","volume":"30","author":"Halperin","year":"2023","journal-title":"Endocr Relat Cancer"},{"issue":"12","key":"10.1016\/j.eprac.2026.04.008_bib12","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/clinem\/dgad368","article-title":"Phenotypic profiling and molecular mechanisms in hyperparathyroidism-jaw tumor syndrome","volume":"108","author":"Tora","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.eprac.2026.04.008_bib13","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s40618-024-02366-7","article-title":"Familial states of primary hyperparathyroidism: an update","volume":"47","author":"Cetani","year":"2024","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"10.1016\/j.eprac.2026.04.008_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/endrev\/bnad009","article-title":"Molecular and clinical spectrum of primary hyperparathyroidism","volume":"44","author":"Jha","year":"2023","journal-title":"Endocr Rev"},{"key":"10.1016\/j.eprac.2026.04.008_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.623667","article-title":"Familial hyperparathyroidism","volume":"12","author":"Blau","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.eprac.2026.04.008_bib16","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.ajhg.2016.08.018","article-title":"GCM2-Activating mutations in familial isolated hyperparathyroidism","volume":"99","author":"Guan","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.eprac.2026.04.008_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/js.2017-00043","article-title":"Ethnicity of patients with germline GCM2-Activating variants and primary hyperparathyroidism","volume":"1","author":"Guan","year":"2017","journal-title":"J Endocr Soc"},{"issue":"1","key":"10.1016\/j.eprac.2026.04.008_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.surg.2017.04.027","article-title":"Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure","volume":"163","author":"El Lakis","year":"2018","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.eprac.2026.04.008_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/jc.2018-01170","article-title":"UMD-MEN1 Database: an Overview of the 370 MEN1 Variants Present in 1676 Patients from the French Population","volume":"104","author":"Romanet","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.eprac.2026.04.008_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s40618-019-01107-5","article-title":"Whole exome sequencing in familial isolated primary hyperparathyroidism","volume":"43","author":"Cetani","year":"2020","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.eprac.2026.04.008_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1244361","article-title":"Genetic testing for familial hyperparathyroidism: clinical-genetic profile in a Mediterranean cohort","volume":"14","author":"Mazarico-Altisent","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"10.1016\/j.eprac.2026.04.008_bib22","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/joim.12523","article-title":"Genetics of parathyroid tumours","volume":"280","author":"Thakker","year":"2016","journal-title":"J Intern Med"},{"issue":"9","key":"10.1016\/j.eprac.2026.04.008_bib23","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1210\/jc.2018-02789","article-title":"New concepts about familial isolated hyperparathyroidism","volume":"104","author":"Marx","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.eprac.2026.04.008_bib24","first-page":"433","article-title":"Phenotype and genotype of patients with multiple endocrine neoplasia type 1 studied in Argentina","volume":"84","author":"Fainstein-Day","year":"2024","journal-title":"Medicina (B Aires)"},{"issue":"4","key":"10.1016\/j.eprac.2026.04.008_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/cen.14254","article-title":"Genetic testing for hereditary hyperparathyroidism and familial hypocalciuric hypercalcaemia in a large UK cohort","volume":"93","author":"Mariathasan","year":"2020","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.eprac.2026.04.008_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1254156","article-title":"GCM2 p.Tyr394Ser variant in Ashkenazi Israeli patients with suspected familial isolated hyperparathyroidism","volume":"14","author":"Szalat","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.eprac.2026.04.008_bib27","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad086","article-title":"Variant tyr 394Ser in the GCM2 gene is rare in a cohort of Ashkenazi Jews with primary hyperparathyroidism","volume":"7","author":"Tolkin","year":"2023","journal-title":"J Endocr Soc"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X26009559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X26009559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:53:17Z","timestamp":1785837197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X26009559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1530891X26009559"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2026.04.008","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Family History Predicts Primary Hyperparathyroidism Regardless of Genetic Predisposition","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2026.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 AACE. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}