{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:39:13Z","timestamp":1792841953204,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.eprac.2026.07.020","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:16:03Z","timestamp":1790810163000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Zoledronic Acid for the Prevention of Hungry Bone Syndrome After Parathyroidectomy in Primary Hyperparathyroidism: A Randomized Placebo-Controlled Trial"],"prefix":"10.1016","author":[{"given":"Akanksha","family":"Gautam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat","family":"Rijal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-8778","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eprac.2026.07.020_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/251410","article-title":"Hyperparathyroidism: An overview","volume":"2011","author":"MacKenzie-Feder","year":"2011","journal-title":"Int J Endocrinol"},{"issue":"5","key":"10.1016\/j.eprac.2026.07.020_bib2","first-page":"694","article-title":"Changes in clinical & biochemical presentations of primary hyperparathyroidism in India over a period of 20 years","volume":"139","author":"Shah","year":"2014","journal-title":"Indian J Med Res"},{"issue":"1","key":"10.1016\/j.eprac.2026.07.020_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5144\/0256-4947.2005.29","article-title":"Primary hyperparathyroidism in North India: a description of 52 cases","volume":"25","author":"Bhansali","year":"2005","journal-title":"Ann Saudi Med"},{"issue":"2","key":"10.1016\/j.eprac.2026.07.020_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00774-017-0833-8","article-title":"Primary hyperparathyroidism: insights from the Indian PHPT registry","volume":"36","author":"Bhadada","year":"2018","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"10.1016\/j.eprac.2026.07.020_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/2230-8210.196023","article-title":"Preoperative zoledronic acid therapy prevent hungry bone syndrome in patients with primary hyperparathyroidism","volume":"21","author":"Mayilvaganan","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.eprac.2026.07.020_bib6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1440-1797.2007.00806.x","article-title":"Administration of pamidronate helps prevent immediate postparathyroidectomy hungry bone syndrome","volume":"12","author":"Davenport","year":"2007","journal-title":"Nephrology"},{"issue":"9","key":"10.1016\/j.eprac.2026.07.020_bib7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1016\/j.eprac.2026.07.020_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00774-005-0680-x","article-title":"Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism","volume":"24","author":"Lee","year":"2006","journal-title":"J Bone Miner Metab"},{"issue":"4","key":"10.1016\/j.eprac.2026.07.020_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.14310\/horm.2002.1286","article-title":"Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid","volume":"9","author":"Corsello","year":"2010","journal-title":"Hormones"},{"key":"10.1016\/j.eprac.2026.07.020_bib10","first-page":"1","article-title":"Profound and protracted hypophosphatemia after A single dose of zoledronic acid infusion for osteoporosis associated with normocalcemic primary hyperparathyroidism","volume":"03","author":"Chiam","year":"2017","journal-title":"Med Case Rep [Internet]"},{"issue":"11","key":"10.1016\/j.eprac.2026.07.020_bib11","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jbmr.4677","article-title":"Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.eprac.2026.07.020_bib12","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/EJE-12-0528","article-title":"Therapy of endocrine disease: hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature","volume":"168","author":"Witteveen","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.eprac.2026.07.020_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.sopen.2021.02.002","article-title":"Monocentric experience of primary hyperparathyroidism surgery in Algeria","volume":"4","author":"Nouikes","year":"2021","journal-title":"Surg Open Sci"},{"issue":"2","key":"10.1016\/j.eprac.2026.07.020_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00774-020-01142-w","article-title":"Progressive rise in the prevalence of asymptomatic primary hyperparathyroidism in India: data from PHPT registry","volume":"39","author":"Arya","year":"2021","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"10.1016\/j.eprac.2026.07.020_bib15","first-page":"379","article-title":"Lessons learned from the management of hungry bone syndrome following the removal of an atypical parathyroid adenoma.J Musculoskelet","volume":"19","author":"Florakis","year":"2019","journal-title":"Neuronal Interact"},{"key":"10.1016\/j.eprac.2026.07.020_bib16","series-title":"The parathyroid glands and metabolic bone disease","author":"Albright","year":"1948"},{"issue":"2","key":"10.1016\/j.eprac.2026.07.020_bib17","first-page":"131","article-title":"Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica","volume":"51","author":"de Fran\u00e7a","year":"2011","journal-title":"Rev Bras Reumatol"},{"issue":"02","key":"10.1016\/j.eprac.2026.07.020_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/a-1325-0351","article-title":"Role of bisphosphonates in the prevention of postoperative hungry bone syndrome in primary hyperparathyroidism: a meta-analysis and need for randomized controlled trials","volume":"71","author":"Pal","year":"2021","journal-title":"Drug Res"},{"issue":"1","key":"10.1016\/j.eprac.2026.07.020_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0300-2977(98)00010-2","article-title":"Consequences of long-term hyperparathyroidism","volume":"53","author":"Graal","year":"1998","journal-title":"Neth J Med"},{"issue":"1","key":"10.1016\/j.eprac.2026.07.020_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/01.ten.0000257439.69010.39","article-title":"A longstanding hungry bone syndrome","volume":"17","author":"Demirci","year":"2007","journal-title":"Endocrinologist"},{"issue":"1","key":"10.1016\/j.eprac.2026.07.020_bib21","first-page":"132","article-title":"Recognition and management of hungry bone syndrome\u2014a case report","volume":"55","author":"Hisham","year":"2000","journal-title":"Med J Malaysia"},{"issue":"4","key":"10.1016\/j.eprac.2026.07.020_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/EJE-21-0322","article-title":"Postoperative zoledronic acid for osteoporosis in primary hyperparathyroidism: a randomized placebo-controlled study","volume":"185","author":"Ryh\u00e4nen","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.eprac.2026.07.020_bib23","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199910213411701","article-title":"A 10-Year prospective study of primary hyperparathyroidism with or without parathyroid surgery","volume":"341","author":"Silverberg","year":"1999","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.eprac.2026.07.020_bib24","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/jbmr.3177","article-title":"Effect of surgery versus observation: skeletal 5-Year outcomes in a randomized trial of patients with primary HPT (the SIPH study): effect of surgery versus observation in PHPT","volume":"32","author":"Lundstam","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.eprac.2026.07.020_bib25","first-page":"394","article-title":"Prediction of bone mass changes after successful parathyroidectomy using biochemical markers of bone metabolism in primary hyperparathyroidism: is it clinically useful?","volume":"63","author":"Ohe","year":"2019","journal-title":"Arch Endocrinol Metab [Internet]"},{"issue":"6","key":"10.1016\/j.eprac.2026.07.020_bib26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00000658-197912000-00019","article-title":"Hyperparathyroid crisis: clinical and pathologic studies of 14 patients","volume":"190","author":"Wang","year":"1979","journal-title":"Ann Surg"},{"key":"10.1016\/j.eprac.2026.07.020_bib27","series-title":"Zoledronic acid not only inhibits osteoclast activity but also enhances mineralisation. Poster No. 0505 presented at: ORS 2012 Annual Meeting; February 4\u20137, 2012","author":"Brennan","year":"2012"},{"issue":"11","key":"10.1016\/j.eprac.2026.07.020_bib28","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1359\/jbmr.080617","article-title":"Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo","volume":"23","author":"Plotkin","year":"2008","journal-title":"J Bone Miner Res"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X26011584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X26011584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:33:42Z","timestamp":1792841622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X26011584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S1530891X26011584"],"URL":"https:\/\/doi.org\/10.1016\/j.eprac.2026.07.020","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preoperative Zoledronic Acid for the Prevention of Hungry Bone Syndrome After Parathyroidectomy in Primary Hyperparathyroidism: A Randomized Placebo-Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eprac.2026.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 AACE. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}