{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:54:34Z","timestamp":1793141674574,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ero.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EULAR Rheumatology Open"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ero.2026.02.017","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:46:45Z","timestamp":1773953205000},"page":"100150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Management of mucocutaneous and joint involvement of Beh\u00e7et\u2019s syndrome: a systematic literature review informing the 2025 update of the EULAR recommendations"],"prefix":"10.1016","volume":"2","author":[{"given":"Sinem Nihal","family":"Esatoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Ozguler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Tomasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Falzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Barete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bettiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Bodaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimira","family":"Boyadzhieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cantarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykut Ferhat","family":"Celik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Dhrif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Ducker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Emmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Henes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Koetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Moots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saadoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Sfikakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Stefanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Talarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Tugal-Tutkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Uygunoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-1135","authenticated-orcid":false,"given":"Gulen","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Ramiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ero.2026.02.017_bib0001","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.rdc.2023.03.010","article-title":"Behcet syndrome","volume":"49","author":"Hatemi","year":"2023","journal-title":"Rheum Dis Clin North Am"},{"issue":"3","key":"10.1016\/j.ero.2026.02.017_bib0002","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0140-6736(23)02629-6","article-title":"Behcet's syndrome","volume":"403","author":"Emmi","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ero.2026.02.017_bib0003","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41572-021-00301-1","article-title":"Behcet syndrome","volume":"7","author":"Yazici","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.ero.2026.02.017_bib0004","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005792-200301000-00006","article-title":"The long-term mortality and morbidity of Behcet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center","volume":"82","author":"Kural-Seyahi","year":"2003","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"10.1016\/j.ero.2026.02.017_bib0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s10067-014-2585-3","article-title":"Unmet need in Behcet's disease: most patients in routine follow-up continue to have oral ulcers","volume":"33","author":"Alibaz-Oner","year":"2014","journal-title":"Clin Rheumatol"},{"issue":"12","key":"10.1016\/j.ero.2026.02.017_bib0006","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/ard.2007.080432","article-title":"EULAR recommendations for the management of Behcet disease","volume":"67","author":"Hatemi","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.ero.2026.02.017_bib0007","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/annrheumdis-2018-213225","article-title":"2018 update of the EULAR recommendations for the management of Behcet's syndrome","volume":"77","author":"Hatemi","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ero.2026.02.017_bib0008","article-title":"Management of major organ involvement in Beh\u00e7et\u2019s syndrome: a systematic literature review informing the 2025 update of the EULAR recommendations","author":"Ozguler","year":"2025","journal-title":"EULAR Rheumatol Open"},{"key":"10.1016\/j.ero.2026.02.017_bib0009","article-title":"2025 Update of the EULAR Recommendations for the Management of Beh\u00e7et\u2019s Syndrome","author":"Hatemi","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ero.2026.02.017_bib0010","unstructured":"EULAR SOPs\u2014Standard Operating Procedures for Task Forces 2025. 2025 Jun 25. [cited 2025 Jun 25] Available from: https:\/\/www.eular.org\/web\/static\/lib\/pdfjs\/web\/viewer.html?file=https:\/\/www.eular.org\/document\/download\/1288\/44fd21f5-69ff-449e-a959-c1398468bfe1\/1198."},{"key":"10.1016\/j.ero.2026.02.017_bib0011","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ero.2026.02.017_bib0012","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ero.2026.02.017_bib0013","series-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"Wells","year":"2014"},{"issue":"20","key":"10.1016\/j.ero.2026.02.017_bib0014","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1056\/NEJMoa1816594","article-title":"Trial of apremilast for oral ulcers in Behcet's syndrome","volume":"381","author":"Hatemi","year":"2019","journal-title":"N Engl J Med"},{"issue":"suppl 10","key":"10.1016\/j.ero.2026.02.017_bib0015","article-title":"Efficacy of apremilast for the treatment of manifestations of Beh\u00e7et\u2019s syndrome other than oral ulcers, including skin lesions and arthritis [abstract]","volume":"72","author":"Hatemi","year":"2020","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.ero.2026.02.017_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002235","article-title":"Impact of apremilast on quality of life in Behcet's syndrome: analysis of the phase 3 RELIEF study","volume":"8","author":"Hatemi","year":"2022","journal-title":"RMD Open"},{"issue":"3","key":"10.1016\/j.ero.2026.02.017_bib0017","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/ard-2024-226113","article-title":"Efficacy and safety of infliximab or adalimumab in severe mucocutaneous Behcet's syndrome refractory to traditional immunosuppressants: a 6-month, multicentre, randomised controlled, prospective, parallel group, single-blind trial","volume":"84","author":"Talarico","year":"2025","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ero.2026.02.017_bib0018","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1093\/rheumatology\/keae585","article-title":"Infliximab vs interferon-alpha in the treatment of Behcet's syndrome: clinical data from the BIO-BEHCET'S randomized controlled trial","volume":"64","author":"Moots","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"10.1016\/j.ero.2026.02.017_bib0019","doi-asserted-by":"crossref","first-page":"e780","DOI":"10.1016\/S2665-9913(24)00194-2","article-title":"Combinations of immunomodulatory agents for prevention of uveitis relapse in patients with severe Behcet's disease already on corticosteroid therapy: a randomised, open-label, head-to-head trial","volume":"6","author":"Zhong","year":"2024","journal-title":"Lancet Rheumatol"},{"issue":"11","key":"10.1016\/j.ero.2026.02.017_bib0020","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300354","article-title":"Infliximab versus cyclophosphamide for severe Behcet's syndrome","volume":"3","author":"Saadoun","year":"2024","journal-title":"NEJM Evid"},{"issue":"Suppl 1","key":"10.1016\/j.ero.2026.02.017_bib0021","first-page":"32","article-title":"OP0046 evaluation of the efficacy of topically applied Tacrolimus in the treatment of oral ulcers in Behcet's disease: a double blind placebo controlled study","volume":"81","author":"Hassanien","year":"2023","journal-title":"nn Rheum Dis"},{"issue":"1","key":"10.1016\/j.ero.2026.02.017_bib0022","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00784-021-04047-8","article-title":"Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial","volume":"26","author":"Nagieb","year":"2022","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10.1016\/j.ero.2026.02.017_bib0023","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/rheumatology\/keae274","article-title":"Exploring relief for Behcet's disease refractory oral ulcers: a comparison of TNF inhibitors versus apremilast","volume":"64","author":"Lopalco","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.ero.2026.02.017_bib0024","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bjoms.2020.07.027","article-title":"New mouthwash: an efficacious intervention for oral ulceration associated with Beh\u00e7et's disease","volume":"58","author":"Senusi","year":"2020","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.ero.2026.02.017_bib0025","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/art.40912","article-title":"Long-term outcome of ustekinumab therapy for Behcet's disease","volume":"71","author":"Mirouse","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"10.1016\/j.ero.2026.02.017_bib0026","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jaad.2021.11.045","article-title":"Efficacy and safety of ustekinumab in Behcet disease: results from the prospective phase 2 STELABEC trial","volume":"87","author":"London","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.ero.2026.02.017_bib0027","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/annrheumdis-2020-217108","article-title":"Long-term effectiveness and safety of secukinumab for treatment of refractory mucosal and articular Behcet's phenotype: a multicentre study","volume":"79","author":"Fagni","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ero.2026.02.017_bib0028","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/ced\/llae284","article-title":"Treatment of Behcet disease with oral roflumilast: an observational study","volume":"50","author":"Penuelas Leal","year":"2024","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ero.2026.02.017_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109682","article-title":"Infliximab for vascular involvement in Behcet's syndrome","volume":"253","author":"Hatemi","year":"2023","journal-title":"Clin Immunol"},{"issue":"5","key":"10.1016\/j.ero.2026.02.017_bib0030","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/ced.14539","article-title":"Efficacy of maggot debridement therapy on refractory leg ulcers of Behcet disease: an open-label study","volume":"46","author":"Kecici","year":"2021","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"10.1016\/j.ero.2026.02.017_bib0031","first-page":"289","article-title":"The effects of adalimumab in Behcet disease patients on clinical manifestations and on pro-inflammatory cytokines milieu: long-term follow-up","volume":"22","author":"Braun-Moscovici","year":"2020","journal-title":"Isr Med Assoc J"},{"issue":"5","key":"10.1016\/j.ero.2026.02.017_bib0032","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s40257-023-00783-7","article-title":"Apremilast long-term safety up to 5 years from 15 pooled randomized, placebo-controlled studies of psoriasis, psoriatic arthritis, and Behcet\u2019s syndrome","volume":"24","author":"Mease","year":"2023","journal-title":"Am J Clin Dermatol"},{"issue":"1","key":"10.1016\/j.ero.2026.02.017_bib0033","first-page":"98","article-title":"Short-term trial of etanercept in Behcet's disease: a double blind, placebo controlled study","volume":"32","author":"Melikoglu","year":"2005","journal-title":"J Rheumatol"},{"issue":"Suppl 10","key":"10.1016\/j.ero.2026.02.017_bib0034","article-title":"Pentoxifylline gel for oral ulcers in patients with Beh\u00e7et\u2019s syndrome [abstract]","volume":"71","author":"Hatemi","year":"2019","journal-title":"Arthritis Rheumatol"}],"container-title":["EULAR Rheumatology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050708126000340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050708126000340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:19:55Z","timestamp":1790900395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050708126000340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S3050708126000340"],"URL":"https:\/\/doi.org\/10.1016\/j.ero.2026.02.017","relation":{},"ISSN":["3050-7081"],"issn-type":[{"value":"3050-7081","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of mucocutaneous and joint involvement of Beh\u00e7et\u2019s syndrome: a systematic literature review informing the 2025 update of the EULAR recommendations","name":"articletitle","label":"Article Title"},{"value":"EULAR Rheumatology Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ero.2026.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR).","name":"copyright","label":"Copyright"}],"article-number":"100150"}}