{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:03:37Z","timestamp":1793419417328,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Science and Ecotechnology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ese.2022.100198","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T02:31:07Z","timestamp":1654482667000},"page":"100198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain"],"prefix":"10.1016","volume":"12","author":[{"given":"Zhenfei","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-574X","authenticated-orcid":false,"given":"Chenglian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangkun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Giesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ese.2022.100198_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41578-019-0164-6","article-title":"Flame-retardant surface treatments","volume":"5","author":"Lazar","year":"2020","journal-title":"Nat. Rev. Mater."},{"issue":"14","key":"10.1016\/j.ese.2022.100198_bib2","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1021\/acs.est.0c01152","article-title":"In\u00a0vitro immunotoxicity of organophosphate flame retardants in human THP-1-derived macrophages","volume":"54","author":"Li","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.ese.2022.100198_bib3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chemosphere.2012.03.067","article-title":"Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis","volume":"88","author":"van der Veen","year":"2012","journal-title":"Chemosphere"},{"issue":"14","key":"10.1016\/j.ese.2022.100198_bib4","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1021\/es501334w","article-title":"Comparative body compartment composition and in ovo transfer of organophosphate flame retardants in North American Great Lakes herring gulls","volume":"48","author":"Greaves","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.ese.2022.100198_bib5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jchromb.2008.12.030","article-title":"Determination of human urinary organophosphate flame retardant metabolites by solid-phase extraction and gas chromatography-tandem mass spectrometry","volume":"877","author":"Schindler","year":"2009","journal-title":"J.\u00a0Chromatogr. B"},{"key":"10.1016\/j.ese.2022.100198_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.envpol.2014.09.012","article-title":"Organophosphorus flame retardants and plasticizers: sources, occurrence, toxicity and human exposure","volume":"196","author":"Wei","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ese.2022.100198_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.chemosphere.2015.11.084","article-title":"Inhalation a significant exposure route for chlorinated organophosphate flame retardants","volume":"150","author":"Schreder","year":"2016","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.ese.2022.100198_bib8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/rcm.2937","article-title":"Liquid chromatography\/tandem mass spectrometry determination of organophosphorus flame retardants and plasticizers in drinking and surface waters","volume":"21","author":"Bacaloni","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.ese.2022.100198_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envint.2017.11.028","article-title":"Presence of diphenyl phosphate and aryl-phosphate flame retardants in indoor dust from different microenvironments in Spain and The Netherlands and estimation of human exposure","volume":"112","author":"Bj\u00f6rnsdotter","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ese.2022.100198_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.scitotenv.2015.11.094","article-title":"Occurrence and distribution of organophosphate triesters and diesters in sludge from sewage treatment plants of Beijing, China","volume":"544","author":"Gao","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ese.2022.100198_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2015.11.008","article-title":"Occurrence, distribution and seasonal variation of organophosphate flame retardants and plasticizers in urban surface water in Beijing, China","volume":"209","author":"Shi","year":"2016","journal-title":"Environ. Pollut."},{"issue":"19","key":"10.1016\/j.ese.2022.100198_bib12","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1021\/acs.est.8b02933","article-title":"Traditional organophosphate esters in house dust from South China: Association with hand wipes and exposure estimation","volume":"52","author":"Tan","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.ese.2022.100198_bib13","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1021\/acs.est.7b01122","article-title":"Organophosphorus flame retardants in pregnant women and their transfer to chorionic villi","volume":"51","author":"Zhao","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib14","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.envpol.2018.07.077","article-title":"Trophic transfer of organophosphorus flame retardants in a lake food web","volume":"242","author":"Zhao","year":"2018","journal-title":"Environ. Pollut."},{"issue":"15","key":"10.1016\/j.ese.2022.100198_bib15","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.1021\/acs.est.0c08822","article-title":"Long-range transport, trophic transfer, and ecological risks of organophosphate esters in remote areas","volume":"55","author":"Fu","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.ese.2022.100198_bib16","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1021\/acs.est.7b00755","article-title":"Organophosphate ester flame retardants and plasticizers in ocean sediments from the north Pacific to the arctic ocean","volume":"51","author":"Ma","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.ese.2022.100198_bib17","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1016\/j.envpol.2011.07.022","article-title":"Organophosphorus flame retardants and plasticizers in the atmosphere of the North Sea","volume":"159","author":"M\u00f6ller","year":"2011","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.ese.2022.100198_bib18","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1021\/es204272v","article-title":"Organophosphorus flame retardants and plasticizers in airborne particles over the Northern Pacific and Indian Ocean toward the Polar Regions: evidence for global occurrence","volume":"46","author":"M\u00f6ller","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128989","article-title":"The potential connections of adverse outcome pathways with the hazard identifications of typical organophosphate esters based on toxicity mechanisms","volume":"266","author":"Yan","year":"2021","journal-title":"Chemosphere"},{"issue":"11","key":"10.1016\/j.ese.2022.100198_bib20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1080\/10934529.2016.1191819","article-title":"The cytotoxicity of organophosphate flame retardants on HepG2, A549 and Caco-2 cells","volume":"51","author":"An","year":"2016","journal-title":"J.\u00a0Environ. Sci. Health"},{"key":"10.1016\/j.ese.2022.100198_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.aquatox.2015.01.027","article-title":"Aryl organophosphate flame retardants induced cardiotoxicity during zebrafish embryogenesis: by disturbing expression of the transcriptional regulators","volume":"161","author":"Du","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"12","key":"10.1016\/j.ese.2022.100198_bib22","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1021\/acs.est.5b00857","article-title":"Investigating endocrine and physiological parameters of captive American kestrels exposed by diet to selected organophosphate flame retardants","volume":"49","author":"Fernie","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.chemosphere.2018.12.198","article-title":"The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos\/larvae","volume":"220","author":"Li","year":"2019","journal-title":"Chemosphere"},{"issue":"11","key":"10.1016\/j.ese.2022.100198_bib24","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1289\/ehp.1205316","article-title":"Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure","volume":"120","author":"McGee","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.ese.2022.100198_bib25","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1021\/acs.est.5b00558","article-title":"Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.aay6637","article-title":"Learning from the past and considering the future of chemicals in the environment","volume":"367","author":"Johnson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ese.2022.100198_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2012.02.019","article-title":"Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish","volume":"114\u2013115","author":"Liu","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib28","first-page":"104","article-title":"Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio)","volume":"134\u2013135","author":"Liu","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.aquatox.2012.11.009","article-title":"Exposure of zebrafish embryos\/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic\u2013pituitary\u2013thyroid axis","volume":"126","author":"Wang","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.aquatox.2016.11.019","article-title":"Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP","volume":"182","author":"Xu","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.envpol.2015.10.045","article-title":"Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus)","volume":"208","author":"Yuan","year":"2016","journal-title":"Environ. Pollut."},{"issue":"24","key":"10.1016\/j.ese.2022.100198_bib32","doi-asserted-by":"crossref","first-page":"14579","DOI":"10.1021\/acs.est.5b03849","article-title":"Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate inhibit growth of female zebrafish and decrease fecundity","volume":"49","author":"Zhu","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ese.2022.100198_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.aquatox.2009.01.013","article-title":"Endocrine disrupting chemicals in fish: developing exposure indicators and predictive models of effects based on mechanism of action","volume":"92","author":"Ankley","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biocon.2019.01.020","article-title":"Worldwide decline of the entomofauna: a review of its drivers","volume":"232","author":"S\u00e1nchez-Bayo","year":"2019","journal-title":"Biol. Conserv."},{"issue":"3","key":"10.1016\/j.ese.2022.100198_bib35","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/es202625r","article-title":"Occurrence of thyroid hormone activities in drinking water from eastern China: contributions of phthalate esters","volume":"46","author":"Shi","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ese.2022.100198_bib36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ieam.109","article-title":"Traits-based approaches in bioassessment and ecological risk assessment: strengths, weaknesses, opportunities and threats","volume":"7","author":"Van den Brink","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"key":"10.1016\/j.ese.2022.100198_bib37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aquatox.2015.01.016","article-title":"Thyroid disruption by triphenyl phosphate an organophosphate flame retardant in zebrafish (Danio rerio) embryos larvae and in GH3 and FRTL-5 cell lines","volume":"160","author":"Kim","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ese.2022.100198_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117374","article-title":"Fish toxicity testing for identification of thyroid disrupting chemicals","volume":"284","author":"Dang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ese.2022.100198_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aquatox.2017.06.020","article-title":"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring","volume":"190","author":"Han","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"14","key":"10.1016\/j.ese.2022.100198_bib40","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1021\/acs.est.9b07205","article-title":"Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption","volume":"54","author":"Knapen","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envint.2011.05.013","article-title":"Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta","volume":"42","author":"Shi","year":"2012","journal-title":"Environ. Int."},{"issue":"23","key":"10.1016\/j.ese.2022.100198_bib42","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.1021\/es303289n","article-title":"Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis","volume":"46","author":"Zheng","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ese.2022.100198_bib43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envpol.2015.11.051","article-title":"Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in\u00a0vitro, in\u00a0vivo and in silico approaches","volume":"210","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ese.2022.100198_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aquatox.2018.08.001","article-title":"Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae","volume":"203","author":"Shi","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"12","key":"10.1016\/j.ese.2022.100198_bib45","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/etc.3477","article-title":"Developmental neurotoxicity of organophosphate flame retardants in early life stages of Japanese medaka (Oryzias latipes)","volume":"35","author":"Sun","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"22","key":"10.1016\/j.ese.2022.100198_bib46","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1021\/acs.est.6b02029","article-title":"Identification of thyroid hormone disruptors among HO-PBDEs: in\u00a0vitro investigations and coregulator involved simulations","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ese.2022.100198_bib47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.etap.2004.06.003","article-title":"T-Screen as a tool to identify thyroid hormone receptor active compounds","volume":"19","author":"Gutleb","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ese.2022.100198_bib48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jhazmat.2016.08.033","article-title":"Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects","volume":"320","author":"Li","year":"2016","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.ese.2022.100198_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126034","article-title":"Competitive binding assays for measuring the binding affinity of thyroid-disrupting chemicals for integrin alphavbeta3","volume":"249","author":"Li","year":"2020","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.ese.2022.100198_bib50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2605.2007.00857.x","article-title":"Thyroid disrupting chemicals: mechanisms and mixtures","volume":"31","author":"Crofton","year":"2008","journal-title":"Int. J. Androl."},{"issue":"4","key":"10.1016\/j.ese.2022.100198_bib51","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.tiv.2013.02.012","article-title":"Mechanism-based testing strategy using in\u00a0vitro approaches for identification of thyroid hormone disrupting chemicals","volume":"27","author":"Murk","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.ese.2022.100198_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104914","article-title":"Organophosphate flame retardants (OPFRs) induce genotoxicity in\u00a0vivo: a survey on apoptosis, DNA methylation, DNA oxidative damage, liver metabolites, and transcriptomics","volume":"130","author":"Chen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ese.2022.100198_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116586","article-title":"In\u00a0vitro metabolic kinetics of cresyl diphenyl phosphate (CDP) in liver microsomes of crucian carp (Carassius carassius)","volume":"274","author":"Yan","year":"2021","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.ese.2022.100198_bib54","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2741\/3720","article-title":"Thyroperoxidase, thyroglobulin, Na+\/I- symporter, pendrin in thyroid autoimmunity","volume":"16","author":"Czarnocka","year":"2011","journal-title":"Front. Biosci."},{"issue":"10","key":"10.1016\/j.ese.2022.100198_bib55","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1210\/endo.139.10.6265","article-title":"Human thyroperoxidase is largely retained and rapidly degraded in the endoplasmic reticulum. Its N-glycans are required for folding and intracellular trafficking","volume":"139","author":"Fayadat","year":"1998","journal-title":"Endocrinology"},{"issue":"14","key":"10.1016\/j.ese.2022.100198_bib56","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1073\/pnas.95.14.8251","article-title":"Autoregulation of thyroid-specific gene transcription by thyroglobulin","volume":"95","author":"Suzuki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ese.2022.100198_bib57","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1210\/endo-94-5-1286","article-title":"Comparison of lactoperoxidase- and thyroid peroxidase-catalyzed iodination and coupling","volume":"94","author":"Taurog","year":"1974","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.ese.2022.100198_bib58","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/jc.2011-2178","article-title":"Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis","volume":"97","author":"Ehlers","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ese.2022.100198_bib59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.imlet.2020.02.003","article-title":"Identification of antigenic epitopes of thyroperoxidase, thyroglobulin and interleukin-24. Exploration of cross-reactivity with environmental allergens and possible role in urticaria and hypothyroidism","volume":"220","author":"S\u00e1nchez","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ese.2022.100198_bib60","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1289\/ehp.02110s3337","article-title":"A\u00a0model of the development of the brain as a construct of the thyroid system","volume":"110","author":"Howdeshell","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ese.2022.100198_bib61","first-page":"433","article-title":"Thyroidal dysfunction and environmental chemicals--potential impact on brain development","volume":"108","author":"Porterfield","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.ese.2022.100198_bib62","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1021\/acs.est.1c05956","article-title":"Thyroid hormone disruption by organophosphate esters is mediated by nuclear\/membrane thyroid hormone receptors: in\u00a0vitro, in\u00a0vivo, and in silico studies","volume":"56","author":"Li","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ese.2022.100198_bib63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/elsc.201600040","article-title":"Lipid biosynthesis in yeasts: a comparison of the lipid biosynthetic pathway between the model nonoleaginous yeast Saccharomyces cerevisiae and the model oleaginous yeast Yarrowia lipolytica","volume":"17","author":"Fakas","year":"2017","journal-title":"Eng. Life Sci."},{"issue":"2","key":"10.1016\/j.ese.2022.100198_bib64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbrc.2015.09.129","article-title":"Genome-wide mRNA-seq profiling reveals predominant down-regulation of lipid metabolic processes in adipose tissues of Small Tail Han than Dorset sheep","volume":"467","author":"Miao","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ese.2022.100198_bib65","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ecoenv.2017.02.042","article-title":"Reproductive toxicity of beta-diketone antibiotic mixtures to zebrafish (Danio rerio)","volume":"141","author":"Wang","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ese.2022.100198_bib66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.envpol.2019.02.102","article-title":"Time-dependent transcriptomic responses of Daphnia magna exposed to metabolic disruptors that enhanced storage lipid accumulation","volume":"249","author":"Fuertes","year":"2019","journal-title":"Environ. Pollut."},{"issue":"6582","key":"10.1016\/j.ese.2022.100198_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe8244","article-title":"From cohorts to molecules: adverse impacts of endocrine disrupting mixtures","volume":"375","author":"Caporale","year":"2022","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ese.2022.100198_bib68","first-page":"2697","article-title":"Predominant intracellular overexpression of the Na (+)\/I (-) symporter (NIS) in a large sampling of thyroid cancer cases","volume":"86","author":"Dohan","year":"2001","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.ese.2022.100198_bib69","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0748233720928165","article-title":"Endocrine disruption: molecular interactions of environmental bisphenol contaminants with thyroid hormone receptor and thyroxine-binding globulin","volume":"36","author":"Beg","year":"2020","journal-title":"Toxicol. Ind. Health"},{"issue":"21","key":"10.1016\/j.ese.2022.100198_bib70","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1056\/NEJM196805232782107","article-title":"Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones","volume":"278","author":"Oppenheimer","year":"1968","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"2","key":"10.1016\/j.ese.2022.100198_bib71","first-page":"933","article-title":"Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain","volume":"130","author":"Chanoine","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.ese.2022.100198_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125749","article-title":"Evaluation of structurally different brominated flame retardants interacting with the transthyretin and their toxicity on HepG2 cells","volume":"246","author":"Chi","year":"2020","journal-title":"Chemosphere"},{"issue":"Pt 2","key":"10.1016\/j.ese.2022.100198_bib73","first-page":"R338","article-title":"Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus","volume":"258","author":"Schreiber","year":"1990","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.ese.2022.100198_bib74","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.beem.2015.09.002","article-title":"Inherited defects of thyroxine-binding proteins","volume":"29","author":"Pappa","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"6","key":"10.1016\/j.ese.2022.100198_bib75","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1039\/C9EM00095J","article-title":"Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors","volume":"21","author":"Qin","year":"2019","journal-title":"Environ. Sci. Process. Impacts."},{"key":"10.1016\/j.ese.2022.100198_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17450-8","article-title":"Anthropogenic stressors impact fish sensory development and survival via thyroid disruption","author":"Besson","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ese.2022.100198_bib77","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.envres.2014.09.019","article-title":"Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus)","volume":"136","author":"Gabrielsen","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.ese.2022.100198_bib78","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tox.2014.08.007","article-title":"Toxicogenomic analysis of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells","volume":"325","author":"Guyot","year":"2014","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.ese.2022.100198_bib79","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1289\/ehp.0900753","article-title":"Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells","volume":"117","author":"Kojima","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ese.2022.100198_bib80","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ygcen.2014.12.010","article-title":"A\u00a0review on the effects of PBDEs on thyroid and reproduction systems in fish","volume":"219","author":"Yu","year":"2015","journal-title":"Gen. Comp. Endocrinol."}],"container-title":["Environmental Science and Ecotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666498422000540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666498422000540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:22:00Z","timestamp":1762993320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666498422000540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":80,"alternative-id":["S2666498422000540"],"URL":"https:\/\/doi.org\/10.1016\/j.ese.2022.100198","relation":{},"ISSN":["2666-4984"],"issn-type":[{"value":"2666-4984","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain","name":"articletitle","label":"Article Title"},{"value":"Environmental Science and Ecotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ese.2022.100198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of Chinese Society for Environmental Sciences, Harbin Institute of Technology, Chinese Research Academy of Environmental Sciences.","name":"copyright","label":"Copyright"}],"article-number":"100198"}}