{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:47:32Z","timestamp":1786988852167,"version":"build-2736575974"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["esmogastro.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Gastrointestinal Oncology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.esmogo.2025.100174","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T13:25:00Z","timestamp":1749129900000},"page":"100174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Fibre, microbes and radiotherapy: unravelling the gut\u2019s impact on radiotherapy in cancer"],"prefix":"10.1016","volume":"9","author":[{"given":"L.","family":"Twhigg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-5829","authenticated-orcid":false,"given":"H.M.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Glyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-4530","authenticated-orcid":false,"given":"R.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.esmogo.2025.100174_bib1","article-title":"Role of the gut microbiota in nutrition and health","volume":"361","author":"Valdes","year":"2018","journal-title":"Br Med J"},{"issue":"29","key":"10.1016\/j.esmogo.2025.100174_bib2","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib3","first-page":"17","article-title":"Part 1: the human gut microbiome in health and disease","volume":"13","author":"Bull","year":"2014","journal-title":"Integr Med (Encinitas)"},{"issue":"6265","key":"10.1016\/j.esmogo.2025.100174_bib4","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aac8469","article-title":"Gut microbiota and aging","volume":"350","author":"O\u2019Toole","year":"2015","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib5","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3390\/nu13051655","article-title":"Dietary fibre modulates the gut microbiota","volume":"13","author":"Cronin","year":"2021","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.esmogo.2025.100174_bib6","doi-asserted-by":"crossref","first-page":"R611","DOI":"10.1016\/j.cub.2015.05.040","article-title":"Gut microbiome: westernization and the disappearance of intestinal diversity","volume":"25","author":"Segata","year":"2015","journal-title":"Curr Biol"},{"issue":"33","key":"10.1016\/j.esmogo.2025.100174_bib7","doi-asserted-by":"crossref","first-page":"14691","DOI":"10.1073\/pnas.1005963107","article-title":"Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa","volume":"107","author":"De Filippo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7402","key":"10.1016\/j.esmogo.2025.100174_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"issue":"6052","key":"10.1016\/j.esmogo.2025.100174_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib10","article-title":"Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1017\/S0007114517003440","article-title":"Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study","volume":"119","author":"Healey","year":"2018","journal-title":"Br J Nutr"},{"issue":"11","key":"10.1016\/j.esmogo.2025.100174_bib12","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/gutjnl-2016-313271","article-title":"Prebiotic inulin-type fructans induce specific changes in the human gut microbiota","volume":"66","author":"Vandeputte","year":"2017","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0007114517002318","article-title":"Impact of \u03b22-1 fructan on faecal community change: results from a placebo-controlled, randomised, double-blinded, cross-over study in healthy adults","volume":"118","author":"Clarke","year":"2017","journal-title":"Br J Nutr"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tem.2016.03.001","article-title":"The fiber gap and the disappearing gut microbiome: implications for human nutrition","volume":"27","author":"Deehan","year":"2016","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2891-13-34","article-title":"CODEX-aligned dietary fiber definitions help to bridge the \u2018fiber gap\u2019","volume":"13","author":"Jones","year":"2014","journal-title":"Nutr J"},{"issue":"8","key":"10.1016\/j.esmogo.2025.100174_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota","volume":"8","author":"Holscher","year":"2017","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/femsre\/fuy002","article-title":"Biochemistry of complex glycan depolymerisation by the human gut microbiota","volume":"42","author":"Ndeh","year":"2018","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.esmogo.2025.100174_bib19","series-title":"Prebiotics and Probiotics Science and Technology","first-page":"639","article-title":"Ecological interactions of bacteria in the human gut","author":"Falony","year":"2009"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib20","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.esmogo.2025.100174_bib21","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1016\/j.tjnut.2023.09.001","article-title":"Tuning expectations to reality: don\u2019t expect increased gut microbiota diversity with dietary fiber","volume":"153","author":"Cantu-Jungles","year":"2023","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib22","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/ajcn\/nqz001","article-title":"Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans","volume":"109","author":"Hiel","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1016\/j.esmogo.2025.100174_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1017\/S0007114510001571","article-title":"A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects","volume":"104","author":"Costabile","year":"2010","journal-title":"Br J Nutr"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib24","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.clnu.2020.12.034","article-title":"Galacto-oligosaccharides supplementation in prefrail older and healthy adults increased faecal bifidobacteria, but did not impact immune function and oxidative stress","volume":"40","author":"Wilms","year":"2021","journal-title":"Clin Nutr"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1017\/S0007114515001889","article-title":"Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons","volume":"114","author":"Vulevic","year":"2015","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2019.1704141","article-title":"Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit","volume":"12","author":"M\u00fcller","year":"2020","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1475-2891-11-36","article-title":"A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers","volume":"11","author":"Walton","year":"2012","journal-title":"Nutr J"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib28","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/jn\/nxac021","article-title":"Substitution of refined conventional wheat flour with wheat high in resistant starch modulates the intestinal microbiota and fecal metabolites in healthy adults: a randomized, controlled trial","volume":"152","author":"Gondalia","year":"2022","journal-title":"J Nutr"},{"issue":"11","key":"10.1016\/j.esmogo.2025.100174_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015046","article-title":"Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects","volume":"5","author":"Mart\u00ednez","year":"2010","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.esmogo.2025.100174_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025200","article-title":"Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans","volume":"6","author":"Davis","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chom.2017.02.012","article-title":"A microbiome foundation for the study of Crohn\u2019s disease","volume":"21","author":"Gevers","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat Rev Microbiol"},{"issue":"6536","key":"10.1016\/j.esmogo.2025.100174_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1053\/j.gastro.2020.11.041","article-title":"Cancer and the microbiome-influence of the commensal microbiota on cancer, immune responses, and immunotherapy","volume":"160","author":"Matson","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s42003-021-01741-x","article-title":"Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation","volume":"4","author":"Sims","year":"2021","journal-title":"Commun Biol"},{"issue":"9","key":"10.1016\/j.esmogo.2025.100174_bib36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41571-023-00785-8","article-title":"Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy","volume":"20","author":"Thomas","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"10.1016\/j.esmogo.2025.100174_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/microorganisms7080271","article-title":"The role of gut microbiota in intestinal inflammation with respect to diet and extrinsic stressors","volume":"7","author":"Lobionda","year":"2019","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-physiol-031522-092054","article-title":"The role of the gut microbiota in the relationship between diet and human health","volume":"85","author":"Perler","year":"2023","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib39","first-page":"153","article-title":"Causal role of infectious agents in cancer: an overview","volume":"8","author":"Masrour-Roudsari","year":"2017","journal-title":"Caspian J Intern Med"},{"issue":"14","key":"10.1016\/j.esmogo.2025.100174_bib40","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.3390\/cancers14143385","article-title":"The tissue-associated microbiota in colorectal cancer: a systematic review","volume":"14","author":"Costa","year":"2022","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cid\/ciu787","article-title":"The bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients","volume":"60","author":"Boleij","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13073-015-0177-8","article-title":"Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment","volume":"7","author":"Burns","year":"2015","journal-title":"Genome Med"},{"issue":"11","key":"10.1016\/j.esmogo.2025.100174_bib43","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41575-019-0209-8","article-title":"Gut microbiota in colorectal cancer: mechanisms of action and clinical applications","volume":"16","author":"Wong","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib44","first-page":"355","article-title":"Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate","volume":"39","author":"Laqueur","year":"1967","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib45","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1053\/j.gastro.2017.08.022","article-title":"Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice","volume":"153","author":"Wong","year":"2017","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib46","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib47","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/ijc.28738","article-title":"Infection, antibiotic therapy and risk of colorectal cancer: a nationwide nested case-control study in patients with type 2 diabetes mellitus","volume":"135","author":"Wang","year":"2014","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2017.03.046","article-title":"Bacterial metabolism affects the C. elegans response to cancer chemotherapeutics","volume":"169","author":"Garc\u00eda-Gonz\u00e1lez","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.esmogo.2025.100174_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104197","article-title":"Effects of microbiota on anticancer drugs: current knowledge and potential applications","volume":"83","author":"Huang","year":"2022","journal-title":"eBioMedicine"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib50","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/j.gastro.2022.10.018","article-title":"Gut microbiota modulation of efficacy and toxicity of cancer chemotherapy and immunotherapy","volume":"164","author":"Chrysostomou","year":"2023","journal-title":"Gastroenterology"},{"issue":"6371","key":"10.1016\/j.esmogo.2025.100174_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1\u2013based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"issue":"6264","key":"10.1016\/j.esmogo.2025.100174_bib52","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"V\u00e9tizou","year":"2015","journal-title":"Science"},{"issue":"6264","key":"10.1016\/j.esmogo.2025.100174_bib53","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti\u2013PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"issue":"6575","key":"10.1016\/j.esmogo.2025.100174_bib54","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.aaz7015","article-title":"Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response","volume":"374","author":"Spencer","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib55","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41522-017-0040-3","article-title":"High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia","volume":"3","author":"Drewes","year":"2017","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40168-018-0451-2","article-title":"Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers","volume":"6","author":"Dai","year":"2018","journal-title":"Microbiome"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib57","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/gutjnl-2016-313189","article-title":"Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer","volume":"67","author":"Manasi","year":"2018","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib58","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41591-019-0405-7","article-title":"Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation","volume":"25","author":"Thomas","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.esmogo.2025.100174_bib59","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2147\/OTT.S218004","article-title":"Comparison of gut microbiome in human colorectal cancer in paired tumor and adjacent normal tissues","volume":"13","author":"Sheng","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib60","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/gutjnl-2015-309595","article-title":"Tumour-associated and non-tumour-associated microbiota in colorectal cancer","volume":"66","author":"Burkhardt","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.esmogo.2025.100174_bib61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fcimb.2020.00151","article-title":"Current sampling methods for gut microbiota: a call for more precise devices","volume":"10","author":"Tang","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.esmogo.2025.100174_bib62","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nut.2018.10.038","article-title":"Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients","volume":"61","author":"Xie","year":"2019","journal-title":"Nutrition"},{"issue":"12","key":"10.1016\/j.esmogo.2025.100174_bib63","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.ajpath.2018.08.015","article-title":"The amount of bifidobacterium genus in colorectal carcinoma tissue in relation to tumor characteristics and clinical outcome","volume":"188","author":"Kosumi","year":"2018","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib64","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/carcin\/23.3.529","article-title":"Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA","volume":"23","author":"Huycke","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.esmogo.2025.100174_bib65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fmicb.2015.00020","article-title":"Microbiota disbiosis is associated with colorectal cancer","volume":"6","author":"Gao","year":"2015","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib66","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib67","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0360-3016(03)00423-1","article-title":"An evidence-based estimate of the appropriate radiotherapy utilization rate for colorectal cancer","volume":"56","author":"Foroudi","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib68","article-title":"Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: a pilot study","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib69","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijrobp.2019.12.040","article-title":"Microbial diversity and composition is associated with patient-reported toxicity during chemoradiation therapy for cervical cancer","volume":"107","author":"Mitra","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"10.1016\/j.esmogo.2025.100174_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082659","article-title":"Impact of pelvic radiotherapy on gut microbiota of gynecological cancer patients revealed by massive pyrosequencing","volume":"8","author":"Nam","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib71","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1111\/jcmm.14289","article-title":"Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy","volume":"23","author":"Wang","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib72","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ijrobp.2020.04.015","article-title":"Gut microbiome composition is associated with a pathologic response after preoperative chemoradiation in patients with rectal cancer","volume":"107","author":"Jang","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13014-021-01899-y","article-title":"The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review","volume":"16","author":"Wang","year":"2021","journal-title":"Radiat Oncol"},{"issue":"9","key":"10.1016\/j.esmogo.2025.100174_bib74","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.3390\/nu13093025","article-title":"The effects of ionizing radiation on gut microbiota, a systematic review","volume":"13","author":"Fernandes","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.esmogo.2025.100174_bib75","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2147\/IJN.S290438","article-title":"Application of radiosensitizers in cancer radiotherapy","volume":"16","author":"Gong","year":"2021","journal-title":"Int J Nanomedicine"},{"issue":"21","key":"10.1016\/j.esmogo.2025.100174_bib76","first-page":"10017","article-title":"The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair","volume":"44","author":"Roos","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib77","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/bjc.2013.21","article-title":"Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair","volume":"108","author":"Groselj","year":"2013","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmm.2020.151425","article-title":"Microbiota and cancer: host cellular mechanisms activated by gut microbial metabolites","volume":"310","author":"Tsvetikova","year":"2020","journal-title":"Int J Med Microbiol"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib79","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/1535-7163.MCT-17-0011","article-title":"Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity","volume":"17","author":"Groselj","year":"2018","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib80","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijrobp.2020.01.015","article-title":"The histone deacetylase inhibitor romidepsin spares normal tissues while acting as an effective radiosensitizer in bladder tumors in vivo","volume":"107","author":"Paillas","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib81","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00889-14","article-title":"Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data","volume":"5","author":"Vital","year":"2014","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.esmogo.2025.100174_bib82","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3390\/cells10071775","article-title":"Butyrate and the intestinal epithelium: modulation of proliferation and inflammation in homeostasis and disease","volume":"10","author":"Salvi","year":"2021","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.esmogo.2025.100174_bib83","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41416-022-01980-7","article-title":"Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients","volume":"127","author":"Eaton","year":"2022","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.esmogo.2025.100174_bib84","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","article-title":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation","volume":"48","author":"Donohoe","year":"2012","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib85","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3892\/ijo.2020.5132","article-title":"Butyrate enhances the efficacy of radiotherapy via FOXO3A in colorectal cancer patient-derived organoids","volume":"57","author":"Park","year":"2020","journal-title":"Int J Oncol"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib86","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12915-020-00836-x","article-title":"Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation","volume":"18","author":"Then","year":"2020","journal-title":"BMC Biol"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib87","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrc3064","article-title":"Targeting hypoxia in cancer therapy","volume":"11","author":"Wilson","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib88","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/antibiotics11030331","article-title":"The interplay among radiation therapy, antibiotics and the microbiota: impact on cancer treatment outcomes","volume":"11","author":"Poonacha","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.esmogo.2025.100174_bib89","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.biopha.2017.05.089","article-title":"Lactobacillus rhamnosus ATCC 7469 exopolysaccharides synergizes with low level ionizing radiation to modulate signaling molecular targets in colorectal carcinogenesis in rats","volume":"92","author":"Zahran","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib90","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201915","article-title":"Suppression of local type I interferon by gut microbiota\u2013derived butyrate impairs antitumor effects of ionizing radiation","volume":"218","author":"Yang","year":"2021","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib91","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI124332","article-title":"Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response","volume":"130","author":"Uribe-Herranz","year":"2020","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.esmogo.2025.100174_bib92","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ccell.2021.07.002","article-title":"Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy","volume":"39","author":"Shiao","year":"2021","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib93","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jviscsurg.2020.08.012","article-title":"Radiation enteritis: diagnostic and therapeutic issues","volume":"157","author":"Loge","year":"2020","journal-title":"J Visc Surg"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib94","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/2040622313510730","article-title":"Radiation-induced small bowel disease: latest developments and clinical guidance","volume":"5","author":"Stacey","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.esmogo.2025.100174_bib95","first-page":"1","article-title":"Management of long-term toxicity from pelvic radiation therapy","volume":"41","author":"Dalsania","year":"2021","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"12","key":"10.1016\/j.esmogo.2025.100174_bib96","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/bjs.7655","article-title":"Risk of recurrence after surgery for chronic radiation enteritis","volume":"98","author":"Lefevre","year":"2011","journal-title":"Br J Surg"},{"key":"10.1016\/j.esmogo.2025.100174_bib97","series-title":"Physiology of the Gastrointestinal Tract","first-page":"2075","article-title":"Mechanisms and consequences of intestinal inflammation","author":"McKay","year":"2012"},{"issue":"8","key":"10.1016\/j.esmogo.2025.100174_bib98","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrgastro.2014.46","article-title":"Radiation enteropathy\u2014pathogenesis, treatment and prevention","volume":"11","author":"Hauer-Jensen","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib99","first-page":"725","article-title":"Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract","volume":"65","author":"Balda","year":"1992","journal-title":"Yale J Biol Med"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib100","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib101","doi-asserted-by":"crossref","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","article-title":"Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier","volume":"298","author":"Karczewski","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.esmogo.2025.100174_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.586392","article-title":"The impact of gut microbiota on radiation-induced enteritis","volume":"11","author":"Jian","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"25","key":"10.1016\/j.esmogo.2025.100174_bib103","doi-asserted-by":"crossref","first-page":"14979","DOI":"10.1073\/pnas.95.25.14979","article-title":"Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin","volume":"95","author":"Wu","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib104","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2307\/3571614","article-title":"Effects of the germfree state on responses of mice to whole-body irradiation","volume":"23","author":"McLaughlin","year":"1964","journal-title":"Radiat Res"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib105","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2307\/3575642","article-title":"Effect of intestinal microflora on the survival time of mice exposed to lethal whole-body \u03b3 irradiation","volume":"88","author":"Onoue","year":"1981","journal-title":"Radiat Res"},{"issue":"37","key":"10.1016\/j.esmogo.2025.100174_bib106","doi-asserted-by":"crossref","first-page":"13254","DOI":"10.1073\/pnas.0504830102","article-title":"Microbial regulation of intestinal radiosensitivity","volume":"102","author":"Crawford","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib107","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gutjnl-2017-313789","article-title":"Radiation induces proinflammatory dysbiosis: transmission of inflammatory susceptibility by host cytokine induction","volume":"67","author":"Gerassy-Vainberg","year":"2018","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.esmogo.2025.100174_bib108","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/j.1572-0241.2008.01868.x","article-title":"The gut microbiota predispose to the pathophysiology of acute postradiotherapy diarrhea","volume":"103","author":"Manichanh","year":"2008","journal-title":"Am J Gastroenterol"},{"issue":"7461","key":"10.1016\/j.esmogo.2025.100174_bib109","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"issue":"9237","key":"10.1016\/j.esmogo.2025.100174_bib110","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/S0140-6736(00)02787-2","article-title":"Topical butyrate for acute radiation proctitis: randomised, crossover trial","volume":"356","author":"Vernia","year":"2000","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.esmogo.2025.100174_bib111","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1158\/1078-0432.CCR-19-0960","article-title":"Microbiota- and radiotherapy-induced gastrointestinal side-effects (MARS) study: a large pilot study of the microbiome in acute and late-radiation enteropathy","volume":"25","author":"Reis Ferreira","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib112","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.ijrobp.2021.07.1713","article-title":"Impact of pelvic radiation therapy for prostate cancer on global metabolic profiles and microbiota-driven gastrointestinal late side effects: a longitudinal observational study","volume":"111","author":"Ferreira","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"10.1016\/j.esmogo.2025.100174_bib113","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/sj.bjc.6601868","article-title":"Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy","volume":"90","author":"McGough","year":"2004","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib114","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3945\/ajcn.116.150565","article-title":"Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy","volume":"106","author":"Wedlake","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib115","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jand.2012.04.005","article-title":"Are low-residue diets still applicable?","volume":"112","author":"Cunningham","year":"2012","journal-title":"J Acad Nutr Diet"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib116","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jand.2020.08.077","article-title":"The efficacy of dietary fiber in managing gastrointestinal toxicity symptoms in patients with gynecologic cancers undergoing pelvic radiotherapy: a systematic review","volume":"121","author":"Croisier","year":"2021","journal-title":"J Acad Nutr Diet"},{"issue":"7","key":"10.1016\/j.esmogo.2025.100174_bib117","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/1751-2980.12061","article-title":"Chronic radiation enteritis and malnutrition","volume":"14","author":"Webb","year":"2013","journal-title":"J Dig Dis"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib118","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0016-5085(95)90321-6","article-title":"Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States","volume":"109","author":"Howard","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.esmogo.2025.100174_bib119","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d1447","article-title":"Managing adult patients who need home parenteral nutrition","volume":"342","author":"Wanten","year":"2011","journal-title":"Br Med J"},{"key":"10.1016\/j.esmogo.2025.100174_bib120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ymben.2018.07.018","article-title":"Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: lessons from genome-scale metabolic modeling","volume":"49","author":"Kumar","year":"2018","journal-title":"Metab Eng"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib121","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jpen.1987","article-title":"Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients","volume":"45","author":"Rosli","year":"2021","journal-title":"J Parenter Enteral Nutr"},{"issue":"2","key":"10.1016\/j.esmogo.2025.100174_bib122","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ejcn.2015.192","article-title":"Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial","volume":"70","author":"Garcia-Peris","year":"2016","journal-title":"Eur J Clin Nutr"},{"issue":"6","key":"10.1016\/j.esmogo.2025.100174_bib123","first-page":"1908","article-title":"Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy; a randomised, double-blind, placebo-controlled trial","volume":"27","author":"Guarner","year":"2012","journal-title":"Nutr Hosp"},{"issue":"3","key":"10.1016\/j.esmogo.2025.100174_bib124","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5737\/1181912x10396100","article-title":"Testing control of radiation induced diarrhea with a psyllium bulking agent: a pilot study","volume":"10","author":"Murphy","year":"2000","journal-title":"Can Oncol Nurs"},{"issue":"11","key":"10.1016\/j.esmogo.2025.100174_bib125","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/apt.12316","article-title":"Systematic review: the efficacy of nutritional interventions to counteract acute gastrointestinal toxicity during therapeutic pelvic radiotherapy","volume":"37","author":"Wedlake","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.esmogo.2025.100174_bib126","author":"Gunnar"},{"issue":"10","key":"10.1016\/j.esmogo.2025.100174_bib127","first-page":"4011","article-title":"Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines","volume":"27","author":"Bowen","year":"2019","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.esmogo.2025.100174_bib128","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.radonc.2020.01.011","article-title":"Fecal microbiota transplantation: a promising treatment for radiation enteritis?","volume":"143","author":"Ding","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.esmogo.2025.100174_bib129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-5-31","article-title":"Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients","volume":"5","author":"Chitapanarux","year":"2010","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.esmogo.2025.100174_bib130","article-title":"Decreasing the adverse effects in pelvic radiation therapy: a randomized controlled trial evaluating the use of probiotics","volume":"8","author":"Ahren","year":"2023","journal-title":"Adv Radiat Oncol"},{"issue":"5","key":"10.1016\/j.esmogo.2025.100174_bib131","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.clnu.2013.10.015","article-title":"A randomized double-blind controlled trial: impact of probiotics on diarrhea in patients treated with pelvic radiation","volume":"33","author":"Demers","year":"2014","journal-title":"Clin Nutr"}],"container-title":["ESMO Gastrointestinal Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949819825000433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949819825000433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:00:39Z","timestamp":1758189639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949819825000433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":131,"alternative-id":["S2949819825000433"],"URL":"https:\/\/doi.org\/10.1016\/j.esmogo.2025.100174","relation":{},"ISSN":["2949-8198"],"issn-type":[{"value":"2949-8198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibre, microbes and radiotherapy: unravelling the gut\u2019s impact on radiotherapy in cancer","name":"articletitle","label":"Article Title"},{"value":"ESMO Gastrointestinal Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmogo.2025.100174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100174"}}