{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:00:53Z","timestamp":1789034453825,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.esmoop.2024.102976","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T22:39:25Z","timestamp":1712961565000},"page":"102976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic value of specific KRAS mutations in patients with colorectal peritoneal metastases"],"prefix":"10.1016","volume":"9","author":[{"given":"M.","family":"Tonello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Baratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sammartino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Di Giorgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Robella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sassaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Framarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Macr\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Graziosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Coccolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.V.","family":"Lippolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gelmini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Deraco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Biacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aulicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De Franciscis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"D\u2019Acapito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Carboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Milone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Donini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fugazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Faviana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pizzolato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Del Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sommariva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.esmoop.2024.102976_bib1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S1470-2045(16)30500-9","article-title":"Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database","volume":"17","author":"Franko","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","article-title":"Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Qu\u00e9net","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1245\/s10434-018-6860-4","article-title":"Sites of recurrence after complete cytoreduction and hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis from colorectal and appendiceal adenocarcinoma: a tertiary center experience","volume":"26","author":"Feferman","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/bjs5.50179","article-title":"Meta-analysis of prognostic factors for patients with colorectal peritoneal metastasis undergoing cytoreductive surgery and heated intraperitoneal chemotherapy","volume":"3","author":"Hallam","year":"2019","journal-title":"BJS Open"},{"key":"10.1016\/j.esmoop.2024.102976_bib5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1158\/2159-8290.CD-22-0035","article-title":"Classification of KRAS-activating mutations and the implications for therapeutic intervention","volume":"12","author":"Johnson","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.esmoop.2024.102976_bib6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/418934a","article-title":"Tumorigenesis: RAF\/RAS oncogenes and mismatch-repair status","volume":"418","author":"Rajagopalan","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.esmoop.2024.102976_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100156","article-title":"Strategies to tackle RAS-mutated metastatic colorectal cancer","volume":"6","author":"Patelli","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.esmoop.2024.102976_bib8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1200\/JCO.2014.59.4812","article-title":"Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer","volume":"33","author":"Van Cutsem","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"23","key":"10.1016\/j.esmoop.2024.102976_bib9","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1056\/NEJMoa2308795","article-title":"Sotorasib plus panitumumab in refractory colorectal cancer with mutated KRAS G12C","volume":"389","author":"Fakih","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.esmoop.2024.102976_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/SLA.0000000000002899","article-title":"Mutations of RAS\/RAF proto-oncogenes impair survival after cytoreductive surgery and HIPEC for peritoneal metastasis of colorectal origin","volume":"268","author":"Schneider","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.esmoop.2024.102976_bib11","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1245\/s10434-016-5211-6","article-title":"Development of a prognostic nomogram for patients with peritoneally metastasized colorectal cancer treated with cytoreductive surgery and HIPEC","volume":"23","author":"Simkens","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib12","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1245\/s10434-019-07378-9","article-title":"RAS mutation decreases overall survival after optimal cytoreductive surgery and hyperthermic intraperitoneal chemotherapy of colorectal peritoneal metastasis: a modification proposal of the peritoneal surface disease severity score","volume":"26","author":"Arjona-Sanchez","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib13","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1245\/s10434-021-11045-3","article-title":"Microsatellite and RAS\/RAF mutational status as prognostic factors in colorectal peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)","volume":"29","author":"Tonello","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib14","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.ejso.2022.06.014","article-title":"The impact of molecular and mismatch repair status on the survival outcomes of surgically treated patients with colorectal peritoneal metastases","volume":"48","author":"Flood","year":"2022","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib15","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1200\/JCO.2013.54.9329","article-title":"Association of age with survival in patients with metastatic colorectal cancer: analysis from the ARCAD clinical trials program","volume":"32","author":"Lieu","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1245\/s10434-016-5712-3","article-title":"The role of neoadjuvant and adjuvant systemic chemotherapy with cytoreductive surgery and heated intraperitoneal chemotherapy for colorectal peritoneal metastases: a systematic review","volume":"24","author":"Waite","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S1470-2045(10)70209-6","article-title":"KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer","volume":"12","author":"Roock","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1200\/JCO.2015.63.9674","article-title":"Extended RAS gene mutation testing in metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy: American Society of Clinical Oncology Provisional Clinical Opinion Update 2015","volume":"34","author":"Allegra","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1200\/JCO.2009.23.3452","article-title":"Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial","volume":"28","author":"Roth","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/SLA.0b013e3182a5025a","article-title":"RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases","volume":"258","author":"Vauthey","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.esmoop.2024.102976_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.21037\/cco.2019.08.11","article-title":"RAS mutation: site of disease and recurrence pattern in colorectal cancer","volume":"8","author":"Bonnot","year":"2019","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1245\/s10434-019-07452-2","article-title":"Prognostic impact of BRAF and KRAS mutation in patients with colorectal and appendiceal peritoneal metastases scheduled for CRS and HIPEC","volume":"27","author":"Graf","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib23","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1245\/s10434-022-12704-9","article-title":"RAS Mutation status should not be used to predict outcome from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases","volume":"30","author":"Bhullar","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejso.2022.10.007","article-title":"External validation of COMPASS and BIOSCOPE prognostic scores in colorectal peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)","volume":"49","author":"Tonello","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib25","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41571-018-0105-0","article-title":"Therapeutic strategies to target RAS-mutant cancers","volume":"15","author":"Ryan","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib26","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1200\/JCO.2012.42.2592","article-title":"Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab","volume":"30","author":"Tejpar","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/1758834015591952","article-title":"Precision medicine in colorectal cancer: the molecular profile alters treatment strategies","volume":"7","author":"Tran","year":"2015","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12071919","article-title":"Study of ras mutations\u2019 prognostic value in metastatic colorectal cancer: STORIA analysis","volume":"12","author":"Ottaiano","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.esmoop.2024.102976_bib29","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/annonc\/mdw261","article-title":"Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by\u00a0the\u00a0AIO colorectal cancer study group","volume":"27","author":"Modest","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.esmoop.2024.102976_bib30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.clcc.2020.04.009","article-title":"KRAS G12C metastatic colorectal cancer: specific features of a new emerging target population","volume":"19","author":"Schirripa","year":"2020","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.esmoop.2024.102976_bib31","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jamasurg.2015.0313","article-title":"Association between specific mutations in KRAS codon 12 and colorectal liver metastasis","volume":"150","author":"Margonis","year":"2015","journal-title":"JAMA Surg"},{"key":"10.1016\/j.esmoop.2024.102976_bib32","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/jcs.182873","article-title":"RAS isoforms and mutations in cancer at a glance","volume":"129","author":"Hobbs","year":"2016","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.esmoop.2024.102976_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48029-z","article-title":"Oncogenic G12D mutation alters local conformations and dynamics of K-Ras","volume":"9","author":"Vatansever","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.esmoop.2024.102976_bib34","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1073\/pnas.1218173110","article-title":"NMR-based functional profiling of RASopathies and oncogenic RAS mutations","volume":"110","author":"Smith","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.esmoop.2024.102976_bib35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.str.2014.12.017","article-title":"Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD","volume":"23","author":"Fetics","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.esmoop.2024.102976_bib36","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1158\/0008-5472.CAN-10-0192","article-title":"Genomic and biological characterization of exon 4 KRAS mutations in human cancer","volume":"70","author":"Janakiraman","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.esmoop.2024.102976_bib37","doi-asserted-by":"crossref","first-page":"E157","DOI":"10.1038\/ctg.2016.18","article-title":"KRAS G12D mutation subtype is a prognostic factor for advanced pancreatic adenocarcinoma","volume":"7","author":"Bournet","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.esmoop.2024.102976_bib38","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1158\/1541-7786.MCR-15-0203","article-title":"Biochemical and structural analysis of common cancer-associated KRAS mutations","volume":"13","author":"Hunter","year":"2015","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.esmoop.2024.102976_bib39","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1158\/1078-0432.CCR-19-0311","article-title":"Class 1, 2, and 3 BRAF-mutated metastatic colorectal cancer: a detailed clinical, pathologic, and molecular characterization","volume":"25","author":"Schirripa","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.esmoop.2024.102976_bib40","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1038\/s41388-018-0634-0","article-title":"Impact of RAS mutation subtype on clinical outcome-a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer","volume":"38","author":"Wiesweg","year":"2019","journal-title":"Oncogene"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924007440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924007440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T05:23:29Z","timestamp":1731734609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702924007440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S2059702924007440"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.102976","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of specific KRAS mutations in patients with colorectal peritoneal metastases","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.102976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"102976"}}