{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:55:38Z","timestamp":1793498138298,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.esmoop.2024.103617","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:45:10Z","timestamp":1719413110000},"page":"103617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comprehensive genomic analysis of adrenocortical carcinoma reveals genetic profiles associated with patient survival"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7079-1917","authenticated-orcid":false,"given":"A.","family":"Sun-Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-9081","authenticated-orcid":false,"given":"C.C.","family":"Juhlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-187X","authenticated-orcid":false,"given":"T.","family":"Carling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-8045","authenticated-orcid":false,"given":"U.","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7175-7102","authenticated-orcid":false,"given":"S.","family":"Bajalica-Lagercrantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.esmoop.2024.103617_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1530\/EJE-13-0519","article-title":"Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care center","volume":"169","author":"Ayala-Ramirez","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103617_bib2","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"10.1016\/j.esmoop.2024.103617_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1210\/er.2013-1029","article-title":"Adrenocortical carcinoma","volume":"35","author":"Else","year":"2014","journal-title":"Endocr Rev"},{"issue":"11","key":"10.1016\/j.esmoop.2024.103617_bib4","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/cncr.23886","article-title":"Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors","volume":"113","author":"Bilimoria","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.esmoop.2024.103617_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/20406223211033103","article-title":"Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment","volume":"12","author":"Shariq","year":"2021","journal-title":"Ther Adv Chronic Dis"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.surg.2018.04.068","article-title":"Longitudinal patterns of recurrence in patients with adrenocortical carcinoma","volume":"165","author":"Glenn","year":"2019","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1245\/s10434-015-4810-y","article-title":"Curative resection of adrenocortical carcinoma: rates and patterns of postoperative recurrence","volume":"23","author":"Amini","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.esmoop.2024.103617_bib8","first-page":"62","article-title":"Role of mitotane in adrenocortical carcinoma - review and state of the art","volume":"14","author":"Paragliola","year":"2018","journal-title":"Eur Endocrinol"},{"issue":"10","key":"10.1016\/j.esmoop.2024.103617_bib9","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S2213-8587(23)00193-6","article-title":"Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study","volume":"11","author":"Terzolo","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"10.1016\/j.esmoop.2024.103617_bib10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s41431-020-0638-4","article-title":"Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes","volume":"28","author":"Frebourg","year":"2020","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.esmoop.2024.103617_bib11","article-title":"Adrenocortical carcinoma: current therapeutic state-of-the-art","volume":"2012","author":"Lebastchi","year":"2012","journal-title":"J\u00a0Oncol"},{"issue":"3","key":"10.1016\/j.esmoop.2024.103617_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1530\/EC-18-0526","article-title":"Adrenocortical carcinoma in patients with MEN1: a kindred report and review of the literature","volume":"8","author":"Wang","year":"2019","journal-title":"Endocr Connect"},{"issue":"24","key":"10.1016\/j.esmoop.2024.103617_bib13","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1200\/JCO.2012.48.0988","article-title":"Adrenocortical carcinoma is a Lynch syndrome-associated cancer","volume":"31","author":"Raymond","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"6","key":"10.1016\/j.esmoop.2024.103617_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ng.2953","article-title":"Integrated genomic characterization of adrenocortical carcinoma","volume":"46","author":"Assie","year":"2014","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.esmoop.2024.103617_bib15","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/cncr.25724","article-title":"MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy","volume":"117","author":"Patterson","year":"2011","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.esmoop.2024.103617_bib16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ecl.2017.01.007","article-title":"Genetics of adrenocortical development and tumors","volume":"46","author":"Lodish","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103617_bib17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ccell.2016.04.002","article-title":"Comprehensive pan-genomic characterization of adrenocortical carcinoma","volume":"29","author":"Zheng","year":"2016","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12022-021-09667-0","article-title":"What did we learn from the molecular biology of adrenal cortical neoplasia? From histopathology to translational genomics","volume":"32","author":"Juhlin","year":"2021","journal-title":"Endocr Pathol"},{"issue":"3","key":"10.1016\/j.esmoop.2024.103617_bib19","doi-asserted-by":"crossref","first-page":"E493","DOI":"10.1210\/jc.2014-3282","article-title":"Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma","volume":"100","author":"Juhlin","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.esmoop.2024.103617_bib20","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1158\/1078-0432.CCR-08-1067","article-title":"Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling","volume":"15","author":"Giordano","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"D1","key":"10.1016\/j.esmoop.2024.103617_bib21","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAP.0000000000000104","article-title":"CTNNB1 (beta-catenin)-altered neoplasia: a review focusing on soft tissue neoplasms and parenchymal lesions of uncertain histogenesis","volume":"23","author":"Agaimy","year":"2016","journal-title":"Adv Anat Pathol"},{"issue":"17","key":"10.1016\/j.esmoop.2024.103617_bib23","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1158\/0008-5472.CAN-05-0593","article-title":"Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors","volume":"65","author":"Tissier","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.esmoop.2024.103617_bib24","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3389\/fonc.2019.01248","article-title":"Multiple targets of the canonical WNT\/beta-catenin signaling in cancers","volume":"9","author":"Lecarpentier","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.esmoop.2024.103617_bib25","article-title":"Comprehensive pan-cancer analysis and the regulatory mechanism of AURKA, a gene associated with prognosis of ferroptosis of adrenal cortical carcinoma in the tumor micro-environment","volume":"13","author":"Lu","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.esmoop.2024.103617_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.lungcan.2015.11.018","article-title":"Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients","volume":"92","author":"Kato","year":"2016","journal-title":"Lung Cancer"},{"key":"10.1016\/j.esmoop.2024.103617_bib27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1186\/s12885-015-1987-1","article-title":"Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma","volume":"15","author":"Sun","year":"2015","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103617_bib28","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/carcin\/bgaa118","article-title":"ARID3A promotes the development of colorectal cancer by upregulating AURKA","volume":"42","author":"Tang","year":"2021","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78024-8","article-title":"Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia","volume":"10","author":"Moreira-Nunes","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12943-020-01305-3","article-title":"Targeting AURKA in cancer: molecular mechanisms and opportunities for Cancer therapy","volume":"20","author":"Du","year":"2021","journal-title":"Mol Cancer"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12885-022-09284-y","article-title":"A\u00a0comprehensive prognostic analysis of POLD1 in hepatocellular carcinoma","volume":"22","author":"Tang","year":"2022","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103617_bib32","first-page":"5591","article-title":"Elevated expression of POLD1 is associated with poor prognosis in breast cancer","volume":"16","author":"Qin","year":"2018","journal-title":"Oncol Lett"},{"issue":"7-8 Pt 2","key":"10.1016\/j.esmoop.2024.103617_bib33","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.lpm.2018.07.004","article-title":"Adrenocortical carcinoma (ACC): when and why should we consider germline testing?","volume":"47","author":"Petr","year":"2018","journal-title":"Presse Med"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103617_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng1279","article-title":"Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53","volume":"36","author":"Katayama","year":"2004","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.esmoop.2024.103617_bib35","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/sj.bjc.6604083","article-title":"Enhancement of radiation response by inhibition of aurora-A kinase using siRNA or a selective aurora kinase inhibitor PHA680632 in p53-deficient cancer cells","volume":"97","author":"Tao","year":"2007","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103617_bib36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41416-022-02082-0","article-title":"Efficacy and safety of radiation therapy in advanced adrenocortical carcinoma","volume":"128","author":"Kimpel","year":"2023","journal-title":"Br J Cancer"},{"issue":"10","key":"10.1016\/j.esmoop.2024.103617_bib37","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1001\/jamaoncol.2019.2963","article-title":"Evaluation of POLE and POLD1 mutations as biomarkers for immunotherapy outcomes across multiple cancer types","volume":"5","author":"Wang","year":"2019","journal-title":"JAMA Oncol"},{"issue":"6","key":"10.1016\/j.esmoop.2024.103617_bib38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/ejendo\/lvad054","article-title":"Outcome of immunotherapy in adrenocortical carcinoma: a retrospective cohort study","volume":"188","author":"Remde","year":"2023","journal-title":"Eur J Endocrinol"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924013863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924013863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T13:08:51Z","timestamp":1728220131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702924013863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2059702924013863"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.103617","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive genomic analysis of adrenocortical carcinoma reveals genetic profiles associated with patient survival","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.103617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"103617"}}