{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:35:19Z","timestamp":1790976919519,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.esmoop.2024.103644","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:48:06Z","timestamp":1721918886000},"page":"103644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Update on gene fusions and the emerging clinicopathological landscape of peritoneal and pleural mesotheliomas and other neoplasms"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-9610","authenticated-orcid":false,"given":"N.","family":"Benzerdjeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dartigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kepenekian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Damiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sequeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Galateau-Salle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Begueret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Damotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Verriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Valmary-Degano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-7821","authenticated-orcid":false,"given":"L.","family":"Villeneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-4974","authenticated-orcid":false,"given":"O.","family":"Glehen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Scherpereel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-3923","authenticated-orcid":false,"given":"F.","family":"Forest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"De la Fourchardiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Paindavoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hourlier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-950X","authenticated-orcid":false,"given":"D.","family":"Pissaloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7817","authenticated-orcid":false,"given":"F.","family":"Tirode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-6975","authenticated-orcid":false,"given":"S.","family":"Lantuejoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.esmoop.2024.103644_bib1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","article-title":"Advances in malignant mesothelioma","volume":"353","author":"Robinson","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.esmoop.2024.103644_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.jtho.2018.08.2036","article-title":"Current and future management of malignant mesothelioma: a consensus report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation","volume":"13","author":"Tsao","year":"2018","journal-title":"J\u00a0Thorac Oncol"},{"issue":"9","key":"10.1016\/j.esmoop.2024.103644_bib3","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jtho.2023.06.011","article-title":"European epidemiology of pleural mesothelioma\u2014real-life data from a Joint Analysis of the Mesoscape Database of the European Thoracic Oncology Platform and the European Society of Thoracic Surgery Mesothelioma Database","volume":"18","author":"Opitz","year":"2023","journal-title":"J\u00a0Thorac Oncol"},{"issue":"12","key":"10.1016\/j.esmoop.2024.103644_bib4","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative molecular characterization of malignant pleural mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103644_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.esmoop.2024.103644_bib6","doi-asserted-by":"crossref","first-page":"e565","DOI":"10.1016\/S2589-7500(21)00104-7","article-title":"The use of a next-generation sequencing-derived machine-learning risk-prediction model (OncoCast-MPM) for malignant pleural mesothelioma: a retrospective study","volume":"3","author":"Zauderer","year":"2021","journal-title":"Lancet Digit Health"},{"issue":"7","key":"10.1016\/j.esmoop.2024.103644_bib7","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/PAS.0000000000000864","article-title":"A\u00a0subset of malignant mesotheliomas in young adults are associated with recurrent EWSR1\/FUS-ATF1 fusions","volume":"41","author":"Desmeules","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1016\/j.esmoop.2024.103644_bib8","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/s41379-020-0646-5","article-title":"EWSR1\/FUS\u2013CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities","volume":"33","author":"Argani","year":"2020","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.esmoop.2024.103644_bib9","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41379-022-01023-9","article-title":"Comprehensive genomic profiling of EWSR1\/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates","volume":"35","author":"Dermawan","year":"2022","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1016\/j.esmoop.2024.103644_bib10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00428-023-03546-1","article-title":"CREB fusion\u2013associated epithelioid mesenchymal neoplasms of the female adnexa: three cases documenting a novel location of an emerging entity and further highlighting an ambiguous misleading immunophenotype","volume":"482","author":"Trecourt","year":"2023","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103644_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/PAS.0000000000001742","article-title":"Cytokeratin-positive malignant tumor in the abdomen with EWSR1\/FUS-CREB fusion: a clinicopathologic study of 8 cases","volume":"46","author":"Shibayama","year":"2022","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.esmoop.2024.103644_bib12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/gcc.23074","article-title":"EWSR1 :: YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: report of 3 cases in support of an emerging entity","volume":"61","author":"Dermawan","year":"2022","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103644_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.21873\/cgp.20388","article-title":"Genetic pathways in peritoneal mesothelioma tumorigenesis","volume":"20","author":"Panagopoulos","year":"2023","journal-title":"Cancer Genomics Proteomics"},{"issue":"6","key":"10.1016\/j.esmoop.2024.103644_bib14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/10935266211021222","article-title":"Malignant mesothelioma with EWSR1-ATF1 fusion in two adolescent male patients","volume":"24","author":"Ren","year":"2021","journal-title":"Pediatr Dev Pathol"},{"issue":"11","key":"10.1016\/j.esmoop.2024.103644_bib15","article-title":"Malignant peritoneal mesothelioma with EWSR1-ATF1 fusion: a case report","volume":"2","author":"Ke","year":"2021","journal-title":"JTO Clin Res Rep"},{"issue":"7","key":"10.1016\/j.esmoop.2024.103644_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29544","article-title":"Mesothelioma with ALK gene mutations in two pediatric patients: clinical course and outcome","volume":"69","author":"Kimpo","year":"2022","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1016\/j.esmoop.2024.103644_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gcc.23094","article-title":"Metastatic sporadic paraganglioma with EWSR1::CREM gene fusion: a unique molecular profile that expands the phenotypic diversity of the molecular landscape of the EWSR1::CREM gene fusion positive tumors","volume":"62","author":"Javaid","year":"2023","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103644_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/gcc.23118","article-title":"NR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid\/microcystic morphology","volume":"62","author":"Agaimy","year":"2023","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103644_bib19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/PAS.0000000000001656","article-title":"Pediatric mesothelioma with ALK fusions: a molecular and pathologic study of 5 cases","volume":"45","author":"Argani","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.esmoop.2024.103644_bib20","series-title":"WHO Classification of Tumours Editorial Board","article-title":"Thoracic tumours","volume":"Volume 5","year":"2021"},{"issue":"6","key":"10.1016\/j.esmoop.2024.103644_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/gcc.23026","article-title":"Wholistic approach: transcriptomic analysis and beyond using archival material for molecular diagnosis","volume":"61","author":"Macagno","year":"2022","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"10.1016\/j.esmoop.2024.103644_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.esmoop.2024.103644_bib23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/modpathol.2017.153","article-title":"Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation","volume":"31","author":"Goode","year":"2018","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.esmoop.2024.103644_bib24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/gcc.22068","article-title":"RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)","volume":"52","author":"Panagopoulos","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"issue":"7","key":"10.1016\/j.esmoop.2024.103644_bib25","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1158\/2767-9764.CRC-22-0518","article-title":"Targeting the clear cell sarcoma oncogenic driver fusion gene EWSR1::ATF1 by HDAC inhibition","volume":"3","author":"Mae","year":"2023","journal-title":"Cancer Res Commun"},{"issue":"12","key":"10.1016\/j.esmoop.2024.103644_bib26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/gcc.20491","article-title":"EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma","volume":"46","author":"Antonescu","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"issue":"10","key":"10.1016\/j.esmoop.2024.103644_bib27","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1158\/1535-7163.MCT-16-0229","article-title":"Genomic landscape of malignant mesotheliomas","volume":"15","author":"Kato","year":"2016","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103644_bib28","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1158\/1535-7163.MCT-15-0583","article-title":"Antagonizing the hedgehog pathway with vismodegib impairs malignant pleural mesothelioma growth in\u00a0vivo by affecting stroma","volume":"15","author":"Meerang","year":"2016","journal-title":"Mol Cancer Ther"},{"issue":"9","key":"10.1016\/j.esmoop.2024.103644_bib29","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/cells9092114","article-title":"Hedgehog signaling and truncated GLI1 in cancer","volume":"9","author":"Doheny","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.esmoop.2024.103644_bib30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jtcvs.2013.08.035","article-title":"Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in\u00a0vitro","volume":"147","author":"You","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.esmoop.2024.103644_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1200\/PO.20.00260","article-title":"Durable response to vismodegib in PTCH1 F1147fs mutant relapsed malignant pleural mesothelioma: implications for mesothelioma drug treatment","author":"Popat","year":"2021","journal-title":"JCO Precis Oncol"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924014133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924014133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:06:39Z","timestamp":1737331599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702924014133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2059702924014133"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.103644","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Update on gene fusions and the emerging clinicopathological landscape of peritoneal and pleural mesotheliomas and other neoplasms","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.103644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"103644"}}