{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:03:56Z","timestamp":1783479836224,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-CC139201"],"award-info":[{"award-number":["RS-2023-CC139201"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["NCC2410821-1"],"award-info":[{"award-number":["NCC2410821-1"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.esmoop.2024.104132","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T12:10:10Z","timestamp":1740399010000},"page":"104132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["PALB2 germline pathogenic variants: frequency, clinical features, and functional analysis of c.3350+5G>A variant in 3987 Korean cancer patients"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6991-863X","authenticated-orcid":false,"given":"M.-C.","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-1512","authenticated-orcid":false,"given":"S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6327-433X","authenticated-orcid":false,"given":"H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-4293","authenticated-orcid":false,"given":"H.-S.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4508-4522","authenticated-orcid":false,"given":"S.-Y.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1622-5490","authenticated-orcid":false,"given":"J.-A.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-0277","authenticated-orcid":false,"given":"J.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-836X","authenticated-orcid":false,"given":"K.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-7158","authenticated-orcid":false,"given":"M.C.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-6009","authenticated-orcid":false,"given":"S.-Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-1075","authenticated-orcid":false,"given":"S.H.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-3903","authenticated-orcid":false,"given":"W.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-6518","authenticated-orcid":false,"given":"J.E.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-0936","authenticated-orcid":false,"given":"E.-H.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-4058","authenticated-orcid":false,"given":"S.-Y.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.esmoop.2024.104132_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/aps.2015.89","article-title":"Cancer predisposition genes: molecular mechanisms and clinical impact on personalized cancer care: examples of lynch and HBOC syndromes","volume":"37","author":"Wang","year":"2016","journal-title":"Acta Pharmacol Sin"},{"issue":"5182","key":"10.1016\/j.esmoop.2024.104132_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A\u00a0strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"issue":"6559","key":"10.1016\/j.esmoop.2024.104132_bib3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.esmoop.2024.104132_bib4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/jamaoncol.2022.0476","article-title":"Expansion of cancer risk profile for BRCA1 and BRCA2 pathogenic variants","volume":"8","author":"Momozawa","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.esmoop.2024.104132_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1060504","article-title":"Clinical usefulness of NGS multi-gene panel testing in hereditary cancer analysis","volume":"14","author":"Anaclerio","year":"2023","journal-title":"Front Genet"},{"issue":"17","key":"10.1016\/j.esmoop.2024.104132_bib6","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1073\/pnas.0811159106","article-title":"PALB2 is an integral component of the BRCA complex required for homologous recombination repair","volume":"106","author":"Sy","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.esmoop.2024.104132_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2006.05.022","article-title":"Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2","volume":"22","author":"Xia","year":"2006","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.esmoop.2024.104132_bib8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cub.2009.02.018","article-title":"PALB2 links BRCA1 and BRCA2 in the DNA-damage response","volume":"19","author":"Zhang","year":"2009","journal-title":"Curr Biol"},{"issue":"4","key":"10.1016\/j.esmoop.2024.104132_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.molcel.2012.07.029","article-title":"Playing the end game: DNA double-strand break repair pathway choice","volume":"47","author":"Chapman","year":"2012","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3390\/ijms23010348","article-title":"Homologous recombination deficiencies and hereditary tumors","volume":"23","author":"Yamamoto","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib11","first-page":"263","article-title":"PALB2: the hub of a network of tumor suppressors involved in DNA damage responses","volume":"1846","author":"Park","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"18","key":"10.1016\/j.esmoop.2024.104132_bib12","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1158\/0008-5472.CAN-22-1535","article-title":"BRCA1-dependent and independent recruitment of PALB2-BRCA2-RAD51 in the DNA damage response and cancer","volume":"82","author":"Foo","year":"2022","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.esmoop.2024.104132_bib13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1200\/JCO.19.01907","article-title":"Cancer risks associated with germline PALB2 pathogenic variants: an international study of 524 families","volume":"38","author":"Yang","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.esmoop.2024.104132_bib14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1913948","article-title":"Breast cancer risk genes \u2013 association analysis in more than 113,000 women","volume":"384","author":"Dorling","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.esmoop.2024.104132_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1086\/491747","article-title":"The use of racial, ethnic, and ancestral categories in human genetics research","volume":"77","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"14","key":"10.1016\/j.esmoop.2024.104132_bib17","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1002\/cncr.32905","article-title":"Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing","volume":"126","author":"Zhou","year":"2020","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib18","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-018-06581-8","article-title":"Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls","volume":"9","author":"Momozawa","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.esmoop.2024.104132_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103033","article-title":"Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes","volume":"60","author":"Mizukami","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.esmoop.2024.104132_bib20","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"Li","year":"2013","journal-title":"arXiv: Genomics"},{"issue":"5","key":"10.1016\/j.esmoop.2024.104132_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A\u00a0framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.esmoop.2024.104132_bib22","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a mapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"issue":"21","key":"10.1016\/j.esmoop.2024.104132_bib23","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","article-title":"A\u00a0statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.esmoop.2024.104132_bib24","article-title":"Haplotype-based variant detection from short-read sequencing","author":"Garrison","year":"2012","journal-title":"arXiv"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.esmoop.2024.104132_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/humu.22932","article-title":"dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs","volume":"37","author":"Liu","year":"2016","journal-title":"Hum Mutat"},{"issue":"5","key":"10.1016\/j.esmoop.2024.104132_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and\u00a0the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.esmoop.2024.104132_bib28","author":"Andrews"},{"issue":"15","key":"10.1016\/j.esmoop.2024.104132_bib29","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.esmoop.2024.104132_bib30","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"16","key":"10.1016\/j.esmoop.2024.104132_bib31","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.esmoop.2024.104132_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"40","key":"10.1016\/j.esmoop.2024.104132_bib33","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1038\/onc.2013.421","article-title":"Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair","volume":"33","author":"Park","year":"2014","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.esmoop.2024.104132_bib34","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.122.003782","article-title":"Functional assays reclassify suspected splice-altering variants of uncertain significance in mendelian channelopathies","volume":"15","author":"O\u2019Neill","year":"2022","journal-title":"Circ Genom Precis Med"},{"issue":"7","key":"10.1016\/j.esmoop.2024.104132_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/jmedgenet-2018-105834","article-title":"Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report","volume":"56","author":"Lopez-Perolio","year":"2019","journal-title":"J\u00a0Med Genet"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jamaoncol.2018.2956","article-title":"Association of breast and ovarian cancers with predisposition genes identified by large-scale sequencing","volume":"5","author":"Lu","year":"2019","journal-title":"JAMA Oncol"},{"issue":"4","key":"10.1016\/j.esmoop.2024.104132_bib37","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/cam4.1376","article-title":"Gene panel testing of 5589 BRCA1\/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer","volume":"7","author":"Hauke","year":"2018","journal-title":"Cancer Med"},{"issue":"7","key":"10.1016\/j.esmoop.2024.104132_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.2170","article-title":"Germline mutations in homologous recombination repair genes among Chinese pancreatic ductal adenocarcinoma patients detected using next-generation sequencing","volume":"11","author":"Jiang","year":"2023","journal-title":"Mol Genet Genomic Med"},{"issue":"28","key":"10.1016\/j.esmoop.2024.104132_bib39","doi-asserted-by":"crossref","first-page":"19817","DOI":"10.18632\/oncotarget.24865","article-title":"Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer","volume":"9","author":"Kondo","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/cam4.4927","article-title":"Characterization of rare histological subtypes of ovarian cancer based on molecular profiling","volume":"12","author":"Takahashi","year":"2023","journal-title":"Cancer Med"},{"issue":"10","key":"10.1016\/j.esmoop.2024.104132_bib41","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.3324\/haematol.2018.207241","article-title":"Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients","volume":"104","author":"Mori","year":"2019","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.esmoop.2024.104132_bib42","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.4143\/crt.2021.978","article-title":"Implication and influence of multigene panel testing with genetic counseling in Korean patients with BRCA1\/2 mutation-negative breast cancer","volume":"54","author":"Park","year":"2022","journal-title":"Cancer Res Treat"},{"issue":"2","key":"10.1016\/j.esmoop.2024.104132_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s10038-019-0680-7","article-title":"A\u00a0systematic review of predicted pathogenic PALB2 variants: an analysis of mutational overlap between epithelial cancers","volume":"65","author":"Janssen","year":"2020","journal-title":"J\u00a0Hum Genet"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00432-015-2051-x","article-title":"Uptake of risk-reducing salpingo-oophorectomy among female BRCA mutation carriers: experience at the National Cancer Center of Korea","volume":"142","author":"Kim","year":"2016","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"36","key":"10.1016\/j.esmoop.2024.104132_bib45","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1200\/JCO.20.02151","article-title":"TBCRC 048: phase II study of\u00a0olaparib for metastatic breast cancer and mutations in homologous recombination-related genes","volume":"38","author":"Tung","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"issue":"22","key":"10.1016\/j.esmoop.2024.104132_bib46","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1200\/JCO.21.00003","article-title":"Phase II study of maintenance\u00a0rucaparib in patients with platinum-sensitive advanced pancreatic cancer and a pathogenic germline or somatic variant\u00a0in\u00a0BRCA1, BRCA2, or PALB2","volume":"39","author":"Reiss","year":"2021","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.esmoop.2024.104132_bib47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41591-023-02704-x","article-title":"First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate\u00a0cancer: the phase 3 TALAPRO-2 trial","volume":"30","author":"Fizazi","year":"2024","journal-title":"Nat Med"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924019033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702924019033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:49:25Z","timestamp":1778834965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702924019033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2059702924019033"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.104132","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PALB2 germline pathogenic variants: frequency, clinical features, and functional analysis of c.3350+5G>A variant in 3987 Korean cancer patients","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2024.104132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"104132"}}