{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:48:29Z","timestamp":1794412109551,"version":"4.9.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.esmoop.2025.105859","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:22:03Z","timestamp":1761646923000},"page":"105859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of a prognostic nomogram for locally advanced oropharyngeal carcinoma treated with intensity-modulated radiotherapy with\/without systemic therapy"],"prefix":"10.1016","volume":"10","author":[{"given":"P.","family":"Bossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-7995","authenticated-orcid":false,"given":"S.","family":"Calza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Licitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maddalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bacigalupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-6344","authenticated-orcid":false,"given":"L.","family":"Belgioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cacicedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Facchinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garcia Castano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-8130","authenticated-orcid":false,"given":"M.","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sanguineti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Argiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Psyrri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.esmoop.2025.105859_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2982","article-title":"The molecular biology of head and neck cancer","volume":"11","author":"Leemans","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.esmoop.2025.105859_bib2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"10.1016\/j.esmoop.2025.105859_bib3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"issue":"12","key":"10.1016\/j.esmoop.2025.105859_bib4","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/jnci\/djad169","article-title":"Global epidemiologic patterns of oropharyngeal cancer incidence trends","volume":"115","author":"Zumsteg","year":"2023","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"10.1016\/j.esmoop.2025.105859_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1200\/JCO.2012.44.0164","article-title":"Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis","volume":"31","author":"O\u2019Sullivan","year":"2013","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.esmoop.2025.105859_bib6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.radonc.2014.09.005","article-title":"Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging","volume":"113","author":"Rios Velazquez","year":"2014","journal-title":"Radiother Oncol"},{"issue":"36","key":"10.1016\/j.esmoop.2025.105859_bib7","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1200\/JCO.2016.72.0748","article-title":"Development and validation of nomograms predictive of overall and progression-free survival in patients with oropharyngeal cancer","volume":"35","author":"Fakhry","year":"2017","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.esmoop.2025.105859_bib8","first-page":"1863","article-title":"ACE-27 as a prognostic tool of severe acute toxicities in patients with head and neck cancer treated with chemoradiotherapy: a real-world, prospective, observational study","volume":"29","author":"Monteiro","year":"2021","journal-title":"Support Care Cancer"},{"issue":"2","key":"10.1016\/j.esmoop.2025.105859_bib9","first-page":"339","article-title":"Potential role of the alcohol and smoking in the squamous cell carcinoma of the head and neck: review of the current literature and new perspectives","volume":"12","author":"Zygogianni","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.esmoop.2025.105859_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1383019","article-title":"Human Papilloma Virus (HPV) driven oropharyngeal cancer in current or previous heavy smokers: should we look for a different treatment paradigm?","volume":"14","author":"Lorini","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.esmoop.2025.105859_bib11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.ijrobp.2015.12.022","article-title":"Molecular profile of human papillomavirus\u2013positive oropharyngeal squamous cell carcinoma stratified by smoking status","volume":"94","author":"Zevallos","year":"2016","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.esmoop.2025.105859_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104216","article-title":"Integrative genomic analysis reveals low T-cell infiltration as the primary feature of tobacco use in HPV-positive oropharyngeal cancer","volume":"25","author":"Wahle","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.esmoop.2025.105859_bib13","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.ijrobp.2017.12.068","article-title":"Prognostic impact of HPV-associated p16 expression and smoking status on outcomes following radiation therapy for oropharyngeal cancer: the MARCH-HPV project","volume":"100","author":"Lassen","year":"2018","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.esmoop.2025.105859_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejca.2018.02.013","article-title":"Does smoking alter the mutation profile of human papillomavirus\u2013driven head and neck cancers?","volume":"94","author":"Mirghani","year":"2018","journal-title":"Eur J Cancer"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702925017284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702925017284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:05:53Z","timestamp":1764302753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702925017284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2059702925017284"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2025.105859","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of a prognostic nomogram for locally advanced oropharyngeal carcinoma treated with intensity-modulated radiotherapy with\/without systemic therapy","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2025.105859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"105859"}}