{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:58:12Z","timestamp":1790222292821,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016916","name":"Royal Marsden Cancer Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022544","name":"Samsung Biomedical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019418","name":"NIHR Maudsley Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.esmoop.2025.106045","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:26:10Z","timestamp":1771961170000},"page":"106045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["SIGNIFIED: whole-body MRI screening in Li\u2013Fraumeni syndrome in the UK"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-9784","authenticated-orcid":false,"given":"E.","family":"Finn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-9886","authenticated-orcid":false,"given":"A.","family":"Sohaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Withey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sardo Infirri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-3713","authenticated-orcid":false,"given":"C.","family":"Bunce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-1257","authenticated-orcid":false,"given":"C.S.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-4029","authenticated-orcid":false,"given":"J.Y.","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Scurr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-3406","authenticated-orcid":false,"given":"R.W.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Eeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.esmoop.2025.106045_bib1","series-title":"GeneReviews\u00ae [Internet]","article-title":"Li-Fraumeni syndrome","author":"Schneider","year":"1993"},{"issue":"23","key":"10.1016\/j.esmoop.2025.106045_bib2","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1002\/cncr.30248","article-title":"Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort","volume":"122","author":"Mai","year":"2016","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.esmoop.2025.106045_bib3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrclinonc.2014.41","article-title":"Li-Fraumeni syndrome: cancer risk assessment and clinical management","volume":"11","author":"McBride","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"issue":"21","key":"10.1016\/j.esmoop.2025.106045_bib4","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1200\/JCO.2014.59.5728","article-title":"Revisiting Li-Fraumeni syndrome from TP53 mutation carriers","volume":"33","author":"Bougeard","year":"2015","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.esmoop.2025.106045_bib5","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1158\/1078-0432.CCR-17-0408","article-title":"Cancer screening recommendations for individuals with Li-Fraumeni syndrome","volume":"23","author":"Kratz","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.esmoop.2025.106045_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jmedgenet-2020-106876","article-title":"UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants","volume":"58","author":"Hanson","year":"2021","journal-title":"J Med Genet"},{"issue":"2","key":"10.1016\/j.esmoop.2025.106045_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10689-017-0034-6","article-title":"Whole body magnetic resonance imaging (WB-MRI) and brain MRI baseline surveillance in TP53 germline mutation carriers: experience from the Li-Fraumeni Syndrome Education and Early Detection (LEAD) clinic","volume":"17","author":"Bojadzieva","year":"2018","journal-title":"Fam Cancer"},{"issue":"3","key":"10.1016\/j.esmoop.2025.106045_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11547-018-0955-7","article-title":"Whole-body magnetic resonance imaging (WB-MRI) in oncology: recommendations and key uses","volume":"124","author":"Petralia","year":"2019","journal-title":"Radiol Med"},{"issue":"1","key":"10.1016\/j.esmoop.2025.106045_bib9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12885-020-6617-x","article-title":"Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response","volume":"20","author":"Fliedner","year":"2020","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.esmoop.2025.106045_bib10","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.2214\/AJR.06.1403","article-title":"Diffusion-weighted MRI in the body: applications and challenges in oncology","volume":"188","author":"Koh","year":"2007","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"10.1016\/j.esmoop.2025.106045_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00330-023-10060-0","article-title":"Assessment of whole-body MRI including diffusion-weighted sequences in the initial staging of breast cancer patients at high risk of metastases in comparison with PET-CT: a prospective cohort study","volume":"34","author":"Hottat","year":"2024","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.esmoop.2025.106045_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40644-020-00315-0","article-title":"Whole-body magnetic resonance imaging (WB-MRI) for cancer screening in asymptomatic subjects of the general population: review and recommendations","volume":"20","author":"Zugni","year":"2020","journal-title":"Cancer Imaging"},{"issue":"3","key":"10.1016\/j.esmoop.2025.106045_bib13","doi-asserted-by":"crossref","DOI":"10.2214\/AJR.15.15532","article-title":"Whole-body MRI screening in children with Li-Fraumeni and other cancer predisposition syndromes","volume":"206","author":"Benusiglio","year":"2016","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"10.1016\/j.esmoop.2025.106045_bib14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10689-017-9965-1","article-title":"Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls","volume":"16","author":"Saya","year":"2017","journal-title":"Fam Cancer"},{"issue":"1","key":"10.1016\/j.esmoop.2025.106045_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40644-018-0162-8","article-title":"Whole-body magnetic resonance imaging of Li-Fraumeni syndrome patients: Observations from a two rounds screening of Brazilian patients","volume":"18","author":"Paix\u00e3o","year":"2018","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.esmoop.2025.106045_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13053-020-0133-5","article-title":"Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants \u2013 the Swedish constitutional TP53 study SWEP53","volume":"18","author":"Omran","year":"2020","journal-title":"Hered Cancer Clin Pract"},{"issue":"12","key":"10.1016\/j.esmoop.2025.106045_bib17","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1001\/jamaoncol.2017.1968","article-title":"Baseline surveillance in Li-Fraumeni syndrome using whole-body magnetic resonance imaging a meta-analysis","volume":"3","author":"Ballinger","year":"2017","journal-title":"JAMA Oncol"},{"issue":"5","key":"10.1016\/j.esmoop.2025.106045_bib18","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3390\/jcm13051223","article-title":"Whole-body MRI screening for carriers of germline TP53 mutations \u2013 a systematic review and meta-analysis","volume":"13","author":"Temperley","year":"2024","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.esmoop.2025.106045_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/humu.24152","article-title":"Specifications of the ACMG\/AMP variant interpretation guidelines for germline TP53 variants","volume":"42","author":"Fortuno","year":"2021","journal-title":"Hum Mutat"},{"issue":"5","key":"10.1016\/j.esmoop.2025.106045_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"2","key":"10.1016\/j.esmoop.2025.106045_bib21","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \u2018personalized\u2019 approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.esmoop.2025.106045_bib22","series-title":"StataCorp. Stata Statistical Software: Release 18","year":"2023"},{"issue":"9","key":"10.1016\/j.esmoop.2025.106045_bib23","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S1470-2045(16)30249-2","article-title":"Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study","volume":"17","author":"Villani","year":"2016","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.esmoop.2025.106045_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/jmedgenet-2019-106407","article-title":"Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: a case-controlled study (SIGNIFY)","volume":"57","author":"Bancroft","year":"2020","journal-title":"J Med Genet"},{"issue":"3","key":"10.1016\/j.esmoop.2025.106045_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10689-016-9964-7","article-title":"Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?","volume":"16","author":"McBride","year":"2017","journal-title":"Fam Cancer"},{"issue":"suppl 15","key":"10.1016\/j.esmoop.2025.106045_bib26","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1200\/JCO.2018.36.15_suppl.1527","article-title":"Evaluation of whole body MRI for early detection of cancer in TP53 mutation carriers: final results of the LIFSCREEN study","volume":"36","author":"Caron","year":"2018","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.esmoop.2025.106045_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2025.105541","article-title":"Li Fraumeni syndrome in the UK: clinical characteristics and outcomes of TP53 carriers","volume":"10","author":"Finn","year":"2025","journal-title":"ESMO Open"},{"issue":"12","key":"10.1016\/j.esmoop.2025.106045_bib28","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1007\/s00330-024-10883-5","article-title":"Image quality of whole-body diffusion MR images comparing deep-learning accelerated and conventional sequences","volume":"34","author":"Ponsiglione","year":"2024","journal-title":"Eur Radiol"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702925019155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702925019155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:12:09Z","timestamp":1777623129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702925019155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2059702925019155"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2025.106045","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIGNIFIED: whole-body MRI screening in Li\u2013Fraumeni syndrome in the UK","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2025.106045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"106045"}}