{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:37:46Z","timestamp":1792715866550,"version":"4.5.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente Reti (2020) - Studi di fattibilit\\u00E0 per la realizzazione di piattaforme clinicoscientifiche di Precision Oncology \\u2013 WP 6 RARITY (Register rAre adult solid canceRs In iTalY)"],"award-info":[{"award-number":["Ricerca Corrente Reti (2020) - Studi di fattibilit\\u00E0 per la realizzazione di piattaforme clinicoscientifiche di Precision Oncology \\u2013 WP 6 RARITY (Register rAre adult solid canceRs In iTalY)"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007565","name":"Consumers, Health, Agriculture and Food Executive Agency","doi-asserted-by":"publisher","award":["947604 \\u2014 STARTER \\u2014 HP-PJ-2019"],"award-info":[{"award-number":["947604 \\u2014 STARTER \\u2014 HP-PJ-2019"]}],"id":[{"id":"10.13039\/501100007565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","esmoopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ESMO Open"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.esmoop.2026.108537","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:35:12Z","timestamp":1790080512000},"page":"108537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pattern and quality of care for rare head and neck cancers treated in expert centres: the experience of the registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)"],"prefix":"10.1016","volume":"11","author":[{"given":"A.","family":"Trama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Licitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2648-5356","authenticated-orcid":false,"given":"M.","family":"Gil Sanjines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bonfarnuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-2239","authenticated-orcid":false,"given":"B.","family":"Vischioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-4846","authenticated-orcid":false,"given":"M.","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"De Berardinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ansarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Manciocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-012X","authenticated-orcid":false,"given":"F.","family":"Nardozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-7892","authenticated-orcid":false,"given":"G.","family":"Mercante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-0940","authenticated-orcid":false,"given":"A.","family":"Mirabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4798-0405","authenticated-orcid":false,"given":"G.","family":"Mari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-0848","authenticated-orcid":false,"given":"F.","family":"Gaino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cavalera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-9704","authenticated-orcid":false,"given":"V.","family":"Gregorc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-0121","authenticated-orcid":false,"given":"M.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-2580","authenticated-orcid":false,"given":"L.D.","family":"Locati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-4998","authenticated-orcid":false,"given":"L.","family":"Sacchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-6859","authenticated-orcid":false,"given":"S.","family":"Cavalieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-5338","authenticated-orcid":false,"given":"L.","family":"Botta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.esmoop.2026.108537_bib2","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.3390\/diagnostics14212365","article-title":"Rare head and neck cancers and pathological diagnosis challenges: a comprehensive literature review","volume":"14","author":"Filippini","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.esmoop.2026.108537_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2024.115147","article-title":"Incidence and survival of rare adult solid cancers in Europe (EUROCARE-6): A population-based study","volume":"214","author":"Trama","year":"2025","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.esmoop.2026.108537_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0283071","article-title":"The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: the protocol for rare head and neck cancers","volume":"18","author":"Trama","year":"2023","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.esmoop.2026.108537_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2022.100602","article-title":"Salivary gland cancer: ESMO\u2013European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow up","volume":"7","author":"van Herpen","year":"2022","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.esmoop.2026.108537_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2024.104121","article-title":"Sinonasal malignancy: ESMO\u2013EURACAN Clinical Practice Guideline for diagnosis, treatment and follow up","volume":"10","author":"Resteghini","year":"2025","journal-title":"ESMO Open"},{"issue":"4","key":"10.1016\/j.esmoop.2026.108537_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.annonc.2020.12.007","article-title":"Nasopharyngeal carcinoma: ESMO\u2013EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow up","volume":"32","author":"Bossi","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.esmoop.2026.108537_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1288695","article-title":"Multimodality treatment in recurrent\/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives","volume":"13","author":"Pannunzio","year":"2024","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.esmoop.2026.108537_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejso.2018.03.030","article-title":"Networking in rare cancers: what was done, what\u2019s next","volume":"45","author":"Frezza","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.esmoop.2026.108537_bib9","article-title":"Management of patients with rare adult solid cancers: objectives and evaluation of European reference networks (ERN) EURACAN","volume":"39","author":"Blay","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.esmoop.2026.108537_bib10","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fonc.2019.00837","article-title":"Quality of care indicators for head and neck cancers: the experience of the European Project RARECAREnet","volume":"9","author":"Trama","year":"2019","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.esmoop.2026.108537_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/21678707.2023.2241347","article-title":"Real world data for rare diseases research: the beginner\u2019s guide to registries","volume":"11","author":"Pisa","year":"2023","journal-title":"Expert Opin Orphan Drugs"},{"key":"10.1016\/j.esmoop.2026.108537_bib14","series-title":"AJCC Cancer Staging Manual","year":"2017"},{"issue":"7","key":"10.1016\/j.esmoop.2026.108537_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/annonc\/mdz146","article-title":"Rare cancers: from centralized referral to networking","volume":"30","author":"Casali","year":"2019","journal-title":"Ann Oncol"},{"issue":"6","key":"10.1016\/j.esmoop.2026.108537_bib18","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/hed.26639","article-title":"The prognostic significance of race in nasopharyngeal carcinoma by histological subtype","volume":"43","author":"Stepan","year":"2021","journal-title":"Head Neck"}],"container-title":["ESMO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702926024828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2059702926024828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:41:04Z","timestamp":1792712464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2059702926024828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2059702926024828"],"URL":"https:\/\/doi.org\/10.1016\/j.esmoop.2026.108537","relation":{},"ISSN":["2059-7029"],"issn-type":[{"value":"2059-7029","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pattern and quality of care for rare head and neck cancers treated in expert centres: the experience of the registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)","name":"articletitle","label":"Article Title"},{"value":"ESMO Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esmoop.2026.108537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of European Society for Medical Oncology.","name":"copyright","label":"Copyright"}],"article-number":"108537"}}