{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:57:16Z","timestamp":1790031436943,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":2500,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Dapoxetine is a short-acting selective serotonin reuptake inhibitor for treatment of premature ejaculation (PE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the efficacy and safety of dapoxetine 30 and 60 mg as needed in Asia-Pacific men with PE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was a prospective, 12-week, open-label study to evaluate the efficacy and safety of flexible-dose dapoxetine in men with PE diagnosed by a Premature Ejaculation Diagnostic Tool score of at least 11, a self-estimated intravaginal ejaculation latency time (IELT) no longer than 2 minutes, and an International Index of Erectile Function erectile function domain score of at least\u00a021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Percentage of subjects reporting their PE as at least \u201cslightly better\u201d using the Clinical Global Impression of Change (CGIC) question.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred eighteen of 285 randomized subjects completed the study. The mean subject age was 45.9 years and 57.7% were Korean. Dosages 1 (30 mg), 2 (30 \u2192 60 mg), and 3 (30 \u2192 60 \u2192 30 mg) were used in 141, 124, and 13 subjects, respectively. At study end, a PE CGIC rating of at least \u201cslightly better\u201d was reported by 77.3%, 92.8%, and 100% of subjects for dosages 1, 2, and 3, respectively (P\u00a0= .49). At study end, a CGIC rating of \u201cslightly better\u201d was reported by 85.2% and 85.3% of subjects with lifelong PE and acquired PE, respectively (P\u00a0= .50). At study end, a CGIC rating of \u201cslightly better\u201d was reported by 84.1% and 86.4% of subjects with an estimated baseline IELT no longer than and at least \u22641 minute, respectively (P\u00a0= .16). The incidence of a CGIC rating of at least \u201cslightly better\u201d was lower in subjects reporting an adverse event of moderate or severe severity and in subjects who increased to and maintained a dapoxetine dose of 60 mg and higher in subjects older than 50 years and in subjects with a baseline estimated IELT of at least 1 minute.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this study, flexible dosing of dapoxetine (30 and 60 mg) appeared effective in the treatment of PE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2015.12.006","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T03:17:10Z","timestamp":1456888630000},"page":"e18-e27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient 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