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Accordingly, the present study investigated mortality and somatic morbidity using a\u00a0sample of transsexual individuals who comprised 98% (n\u00a0= 104) of all surgically reassigned transsexual individuals in Denmark.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate somatic morbidity before and after SRS and cause of death and its relation to somatic morbidity after SRS in Danish individuals who underwent SRS from 1978 through\u00a02010.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Somatic morbidity and mortality in 104 sex-reassigned individuals were identified retrospectively by data from the Danish National Health Register and the Cause of Death Register.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Somatic morbidity and cause of death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 19.2% of the sample were registered with somatic morbidity before SRS and 23.1% after SRS (P\u00a0= not significant). In total, 8.6% had somatic morbidity before and after SRS. The most common diagnostic category was cardiovascular disease, affecting 18 individuals, 9 before and 14 after SRS, and 5 of those 14 who were affected after SRS had cardiovascular disease before and after SRS. Ten individuals died after SRS at an average age of 53.5 \u00b1 7.9 years (male to female) and 53.5 \u00b1 7.3 years (female to male).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Of 98% of all Danish transsexuals who officially underwent SRS from 1978 through 2010, one in three had somatic morbidity and approximately 1 in 10 had died. No significant differences in somatic morbidity or mortality were found between male-to-female and female-to-male individuals. Despite the young average age at death and the relatively larger number of individuals with somatic morbidity, the present study design does not allow for determination of casual relations between, for example, specific types of hormonal or surgical treatment received and somatic morbidity and mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2016.01.001","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T03:16:55Z","timestamp":1456888615000},"page":"e60-e68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long-Term Follow-Up of Individuals Undergoing Sex-Reassignment Surgery: Somatic Morbidity and Cause of Death"],"prefix":"10.1093","volume":"4","author":[{"given":"Rikke Kildev\u00e6ld","family":"Simonsen","sequence":"first","affiliation":[{"name":"Department of Sexology , Copenhagen , Denmark"},{"name":"University Hospital of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert Martin","family":"Hald","sequence":"additional","affiliation":[{"name":"Department of Public Health , Copenhagen , Denmark"},{"name":"University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellids","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Sexological Clinic , Copenhagen , Denmark"},{"name":"Psychiatric Center Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Giraldi","sequence":"additional","affiliation":[{"name":"Sexological Clinic , Copenhagen , Denmark"},{"name":"Psychiatric Center Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"2023011904395398100_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/15532739.2010.509215","article-title":"Recommendations for revision of the DSM diagnoses of gender identity disorder","volume":"12","author":"Knudson","year":"2010","journal-title":"Int J Transgend"},{"key":"2023011904395398100_bib2","article-title":"The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research","author":"World Health Organisation","year":"1993"},{"key":"2023011904395398100_bib3","article-title":"The ICD-8 classification of mental and behavioural disorders: diagnostic criteria for research","author":"World Health Organisation","year":"1965"},{"key":"2023011904395398100_bib4","article-title":"VEJ nr 10353 af 19\/12\/2014 G\u00e6ldende (vejledning om transk\u00f8nnede)","author":"Ministeriet for Sundhed og Forebyggelse","year":"2015"},{"key":"2023011904395398100_bib5","article-title":"Copenhagen, Denmark: Sundhedsloven [The Danish Health Act]","author":"Sundhedsministeriet (Danish Health Authority)","year":"2014"},{"key":"2023011904395398100_bib6","doi-asserted-by":"crossref","first-page":"e16885","DOI":"10.1371\/journal.pone.0016885","article-title":"Long-term follow-up of transsexual persons undergoing sex reassignment surgery: cohort study in Sweden","volume":"6","author":"Dhejne","year":"2011","journal-title":"PLoS One"},{"key":"2023011904395398100_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03632.x","article-title":"Effect of sex steroid use on cardiovascular risk in transsexual individuals: a systematic review and meta-analyses","volume":"72","author":"Elamin","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2023011904395398100_bib8","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1210\/jc.2003-030520","article-title":"Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people","volume":"88","author":"Toorians","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"2023011904395398100_bib9","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/gme.0b013e3182175e5c","article-title":"Does the route of administration for estrogen hormone therapy impact the risk of venous thromboembolism? 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