{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:21:51Z","timestamp":1777944111819,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":2472,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"TriHealth Medical Education Research Fund"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Female sexual dysfunction affects up to 43% of women in the United States and hypoactive sexual desire disorder (HSDD) is the most common type; however, we lack treatment options showing improvement for this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether acupuncture therapy could improve HSDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Premenopausal women with a primary diagnosis of HSDD were included in a single-arm prospective pilot study that was approved by the institutional review board. After providing informed consent, subjects completed validated questionnaires. Participants underwent 25-minute twice-weekly acupuncture sessions for 5 weeks with one certified acupuncturist. Questionnaires were completed again 6 weeks after onset of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Based on a statistically significant change in the desire domain of the Female Sexual Function Index from 2.0 (at baseline) to 2.4 (after intervention with a specialist) in our population of patients diagnosed with HSDD, a sample of 13 was determined, with 90% power and \u03b1 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen women were enrolled and 13 completed the study. Mean age was 36.9 \u00b1 11.4 years. Most were white (n\u00a0= 9, 60%), heterosexual (n\u00a0= 15, 100%), and non-smokers (n\u00a0= 14, 93%). Most were sexually active more than four times per month (n\u00a0= 8, 53%) and none had a history of sexual abuse (n\u00a0= 15, 100%). Participants received a mean acupuncture needle application of 17 \u00b1 2 at each session. Sexual function improved after intervention, particularly desire (2.1 \u00b1 0.6 to 3.3 \u00b1 1.2, P &amp;lt; .0001), arousal (P &amp;lt; .0001), lubrication (P\u00a0=\u00a0.03), and orgasm (P\u00a0= .005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort of premenopausal women with HSDD, 5 weeks of acupuncture therapy was associated with significant improvements in sexual function, particularly desire. This supports a role for acupuncture as a therapeutic option for women with low desire.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.esxm.2016.02.005","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:42:15Z","timestamp":1459298535000},"page":"e176-e181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acupuncture in Premenopausal Women With Hypoactive Sexual Desire Disorder: A Prospective Cohort Pilot Study"],"prefix":"10.1093","volume":"4","author":[{"given":"Susan H.","family":"Oakley","sequence":"first","affiliation":[{"name":"Female Pelvic Medicine and Reconstructive Surgery \u00a0 , Cincinnati, OH , USA"},{"name":"Good Samaritan Hospital \u00a0 , Cincinnati, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Walther-Liu","sequence":"additional","affiliation":[{"name":"Acupuncture and Holistic Health \u00a0 , Cincinnati, OH , USA"},{"name":"TriHealth \u00a0 , Cincinnati, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Crisp","sequence":"additional","affiliation":[{"name":"Female Pelvic Medicine and Reconstructive Surgery \u00a0 , Cincinnati, OH , USA"},{"name":"Good Samaritan Hospital \u00a0 , Cincinnati, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N.","family":"Pauls","sequence":"additional","affiliation":[{"name":"Female Pelvic Medicine and Reconstructive Surgery \u00a0 , Cincinnati, OH , USA"},{"name":"Good Samaritan Hospital \u00a0 , Cincinnati, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"2023011908375143500_bib1","first-page":"888","article-title":"Report of the International Consensus Development Conference on Female Sexual Dysfunction: definitions and classifications","volume":"163","author":"Basson","year":"2000","journal-title":"J\u00a0Urol"},{"key":"2023011908375143500_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/00926239308404902","article-title":"Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic","volume":"19","author":"Rosen","year":"1993","journal-title":"J\u00a0Sex Marital Ther"},{"key":"2023011908375143500_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/0092623X.2011.560533","article-title":"Sexual desire, distress, and associated factors in premenopausal women: preliminary findings from the Hypoactive Sexual Desire Disorder Registry for Women","volume":"37","author":"Connor","year":"2011","journal-title":"J\u00a0Sex Marital Ther"},{"key":"2023011908375143500_bib4","first-page":"635","article-title":"Diagnosis and treatment of female sexual dysfunction","volume":"77","author":"Frank","year":"2008","journal-title":"Am Fam Physician"},{"key":"2023011908375143500_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1142\/S0192415X04001837","article-title":"Alternative therapies for male and female sexual dysfunction","volume":"32","author":"Aung","year":"2004","journal-title":"Am J Chin Med"},{"key":"2023011908375143500_bib6","first-page":"1","article-title":"Sexual dysfunction: a modern medical acupuncture approach","volume":"13","author":"Aung","year":"2000","journal-title":"Med Acupunct"},{"key":"2023011908375143500_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/00365599709070347","article-title":"Acupuncture and hypnotic suggestions in the treatment of non-organic male sexual dysfunction","volume":"31","author":"Aydin","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"2023011908375143500_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.maturitas.2011.06.011","article-title":"Complementary and alternative medicine (CAM) for sexual dysfunction and erectile dysfunction in older men and women: an overview of systematic reviews","volume":"70","author":"Ernst","year":"2011","journal-title":"Maturitas"},{"key":"2023011908375143500_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3727\/036012908803861122","article-title":"Randomized control trial of hand acupuncture for female stress urinary incontinence","volume":"33","author":"Kim","year":"2008","journal-title":"Acupunct Electrother Res Int J"},{"key":"2023011908375143500_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.47102\/annals-acadmedsg.V37N3p215","article-title":"Care of women in menopause: sexual function, dysfunction and therapeutic modalities","volume":"37","author":"Mattar","year":"2008","journal-title":"Ann Acad Med Singapore"},{"key":"2023011908375143500_bib11","author":"National Center for Complementary and Integrative Health. 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