{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:49:30Z","timestamp":1786988970188,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":1616,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the practice patterns for GPA using HA filler among Korean urologists, and to identify whether urologist experienced patient reports of sexual dysfunction post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between March 2016 and July 2016, a specially designed questionnaire was mailed to 86 selected Korean urologists who had used injectable materials to treat PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The prevalence and awareness of sexual dysfunction after GPA using HA filler were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 56 urologists completed the survey (response rate: 69.2%), of which 36 (64.3%) had performed GPA\u00a0using HA filler. They reported having performed a combined total of 4,344 such GPA procedures. Most urologists (72.7%) performed GPA using HA filler in patients who benefit from topical anesthetics. Patients with a history of failed\u00a0pharmacotherapy (59.1%) and selective dorsal nerve neurotomy (45.5%) were selected for GPA using HA filler. The respondents (44.4%) encountered overall 206 (4.7%) cases of patients reports of recurrence of PE. Interestingly, only 36 (0.8%) cases of glans pain or paresthesia and no cases of erectile dysfunction post-treatment were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Korean urologists performed GPA using HA filler when pharmacotherapy failed or if there was a response to topical treatment. Paresthesia and hypoesthesia after GPA using HA filler are rare, and no cases of erectile dysfunction were encountered by Korean urologists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.esxm.2018.06.005","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T09:46:28Z","timestamp":1533203188000},"page":"297-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation"],"prefix":"10.1093","volume":"6","author":[{"given":"Hyeong Guk","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Urology, Korea University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Tae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Urology, Korea University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Korea University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Association of Korean Urologists , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Association of Korean Urologists , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Sun","family":"Uh","sequence":"additional","affiliation":[{"name":"Association of Korean Urologists , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Korea University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du Geon","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Urology, Korea University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"2023011909354346700_bib1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.eururo.2006.07.004","article-title":"The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking","volume":"51","author":"Porst","year":"2007","journal-title":"Eur Urol"},{"key":"2023011909354346700_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.ijir.3901250","article-title":"Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors","volume":"17","author":"Laumann","year":"2005","journal-title":"Int J Impot Res"},{"key":"2023011909354346700_bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/jama.281.6.537","article-title":"Sexual dysfunction in the United States: prevalence and predictors","volume":"281","author":"Laumann","year":"1999","journal-title":"JAMA"},{"key":"2023011909354346700_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/sm2.28","article-title":"An update of the International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE)","volume":"2","author":"Althof","year":"2014","journal-title":"Sex Med"},{"key":"2023011909354346700_bib5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1464-410X.2009.08456.x","article-title":"PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicenter, double-blind, placebo-controlled study","volume":"103","author":"Dinsmore","year":"2009","journal-title":"BJU Int"},{"key":"2023011909354346700_bib6","first-page":"524","article-title":"Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials","volume":"8","author":"McMahon","year":"2011","journal-title":"J\u00a0Sex Med"},{"key":"2023011909354346700_bib7","first-page":"1826","article-title":"Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies","volume":"161","author":"McMahon","year":"1999","journal-title":"J\u00a0Urol"},{"key":"2023011909354346700_bib8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ijir.2009.21","article-title":"Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation","volume":"21","author":"Aversa","year":"2009","journal-title":"Int J Impot Res"},{"key":"2023011909354346700_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.urology.2011.09.031","article-title":"On-demand tramadol hydrochloride use in premature ejaculation treatment","volume":"79","author":"Kaynar","year":"2012","journal-title":"Urology"},{"key":"2023011909354346700_bib10","first-page":"199","article-title":"Urologist practice patterns in the management of premature ejaculation: a nationwide survey","volume":"5","author":"Shindel","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023011909354346700_bib11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/jbm.820270903","article-title":"Hylan gel biomaterial: dermal and immunologic compatibility","volume":"27","author":"Larsen","year":"1993","journal-title":"J\u00a0Biomed Mater Res"},{"key":"2023011909354346700_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D325V7Q60X","article-title":"Reversible vs nonreversible fillers in facial aesthetics: concerns and considerations","volume":"14","author":"Smith","year":"2008","journal-title":"Dermatol Online J"},{"key":"2023011909354346700_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/ijir.2008.26","article-title":"Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation","volume":"20","author":"Kwak","year":"2008","journal-title":"Int J Impot Res"},{"key":"2023011909354346700_bib14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.ijir.3901226","article-title":"Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation","volume":"16","author":"Kim","year":"2004","journal-title":"Int J Impot Res"},{"issue":"Suppl","key":"2023011909354346700_bib15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1439-0272.2011.01244.x","article-title":"Treatment of premature ejaculation by glans penis augmentation using hyaluronic acid gel: a pilot study","volume":"44","author":"Abdallah","year":"2012","journal-title":"Andrologia"},{"key":"2023011909354346700_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5534\/wjmh.2013.31.3.226","article-title":"Urologist's practice patterns including surgical treatment in the management of premature ejaculation: a Korean nationwide survey","volume":"31","author":"Yang","year":"2013","journal-title":"World J Mens Health"},{"key":"2023011909354346700_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5534\/wjmh.2016.34.3.217","article-title":"Diagnosis and treatment of premature ejaculation by urologists in South Korea","volume":"34","author":"Seo","year":"2016","journal-title":"World J Mens Health"},{"key":"2023011909354346700_bib18","first-page":"404","article-title":"Are urology residents ready to treat premature ejaculation after their training?","volume":"9","author":"Luj\u00e1n","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"2023011909354346700_bib19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","article-title":"Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation","volume":"57","author":"Hatzimouratidis","year":"2010","journal-title":"Eur Urol"},{"key":"2023011909354346700_bib20","first-page":"290","article-title":"AUA guideline on the pharmacologic management of premature ejaculation","volume":"172","author":"Montague","year":"2004","journal-title":"J\u00a0Urol"},{"key":"2023011909354346700_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00004714-199808000-00004","article-title":"Effect of SSRI anti-depressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline","volume":"18","author":"Waldinger","year":"1998","journal-title":"J\u00a0Clin Psychopharmacol"},{"key":"2023011909354346700_bib22","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/ijcp.12700","article-title":"Assessing satisfaction in men with premature ejaculation after dapoxetine treatment in real-world practice","volume":"69","author":"Jiann","year":"2015","journal-title":"Int J Clin Pract"},{"key":"2023011909354346700_bib23","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1464-410X.2003.04773.x","article-title":"Topical anesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study","volume":"93","author":"Busato","year":"2004","journal-title":"BJU Int"},{"key":"2023011909354346700_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.ijir.3901044","article-title":"Human glans penis augmentation using injectable hyaluronic acid gel","volume":"15","author":"Kim","year":"2003","journal-title":"Int J Impot Res"}],"container-title":["Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S205011611830059X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S205011611830059X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/6\/4\/297\/48768722\/smoa_6_4_297.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/6\/4\/297\/48768722\/smoa_6_4_297.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T06:21:49Z","timestamp":1674109309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/smoa\/article\/6\/4\/297\/6956410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.esxm.2018.06.005","relation":{},"ISSN":["2050-1161"],"issn-type":[{"value":"2050-1161","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,8,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation","name":"articletitle","label":"Article Title"},{"value":"Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esxm.2018.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc. on behalf of the International Society for Sexual Medicine.","name":"copyright","label":"Copyright"}]}}