{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:45:08Z","timestamp":1780364708638,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":1540,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Non-curvature penile deformities associated with loss of erect penile volume are often overlooked and have not been thoroughly investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To describe the prevalence and functional impact of penile volume-loss deformities in our cohort of men with Peyronie\u2019s disease (PD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively examined medical records of patients with PD consecutively evaluated by a specialized urologist from December 2012 to June 2016. We excluded patients with prior surgical correction of PD, prior penile prosthesis, and inadequate erection during office examination. All patients underwent deformity assessment of the erect penis after intracavernosal injection. The assessment included measurement of penile curvature; evaluation for hourglass deformities, indentations, and distal tapering; and application of axial force to assess for penile buckling. Prior to the deformity assessment, each patient completed the Male Sexual Health Questionnaire and was asked if he experienced psychological distress and functional impairment related to his penile deformity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>The primary clinical parameters that we evaluated were presence or absence of axial instability, functional impairment, psychological distress, penile pain, erectile dysfunction, ejaculatory dysfunction, sexual dissatisfaction, decreased sexual activity, and decreased sexual desire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>128 patients met criteria for inclusion. 83 patients (65%) had volume-loss deformities. Unilateral indentations, hourglass deformities, and distal tapering were present in 50 (39%), 30 (23%), and 16 (13%) patients, respectively. Penile curvature &amp;lt;10\u00b0 degrees was present in 115 patients (90%). After controlling for angle of curvature, patients with volume-loss deformities had significantly higher rates of axial instability (odds ratio [OR]\u00a0= 3.5, P\u00a0= .01) and psychological distress (OR\u00a0= 2.6, P\u00a0= .03), as well as decreased sexual activity (OR\u00a0= 2.7, P\u00a0= .02), than patients with non\u2013volume-loss deformities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Volume-loss penile deformities are highly prevalent in men with PD. These deformities are associated with penile axial instability and psychological distress, which may contribute to decreased frequency of sexual activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T21:11:53Z","timestamp":1539810713000},"page":"309-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Beyond Curvature: Prevalence and Characteristics of Penile Volume-Loss Deformities in Men With Peyronie's Disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Ezra J.","family":"Margolin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie M.","family":"Aisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyi C.","family":"Onyeji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"2023011909355796700_bib1","first-page":"1527","article-title":"Peyronie's disease (CME)","volume":"4","author":"Bella","year":"2007","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib2","first-page":"2350","article-title":"Subjective and objective analysis of the prevalence of Peyronie\u2019s disease in a population of men presenting for prostate cancer screening","volume":"171","author":"Mulhall","year":"2004","journal-title":"J\u00a0Urology"},{"key":"2023011909355796700_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie's disease: results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"key":"2023011909355796700_bib4","first-page":"905","article-title":"Evidence-based management guidelines on Peyronie's disease","volume":"13","author":"Chung","year":"2016","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.sxmr.2017.10.002","article-title":"Penile length: measurement technique and applications","volume":"6","author":"Davoudzadeh","year":"2018","journal-title":"Sex Med Rev"},{"key":"2023011909355796700_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.urology.2017.11.012","article-title":"Conservatively managed Peyronie's disease-long-term survey results from patients undergoing nonsurgical and noninjection therapies","volume":"113","author":"Ziegelmann","year":"2018","journal-title":"Urology"},{"key":"2023011909355796700_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ucl.2007.08.017","article-title":"Peyronie's disease","volume":"34","author":"Taylor","year":"2007","journal-title":"Urol Clin North Am"},{"key":"2023011909355796700_bib8","first-page":"2077","article-title":"Peyronie's disease among men who have sex with men: characteristics, treatment, and psychosocial factors","volume":"10","author":"Farrell","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib9","first-page":"1174","article-title":"The clinical characteristics of Peyronie's patients with notching deformity","volume":"4","author":"Cakan","year":"2007","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib10","first-page":"1985","article-title":"The chronology of depression and distress in men with Peyronie's disease","volume":"5","author":"Nelson","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib11","first-page":"1977","article-title":"Impact of Peyronie's disease on sexual and psychosocial functioning: qualitative findings in patients and controls","volume":"5","author":"Rosen","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib12","first-page":"2179","article-title":"Risk factors for emotional and relationship problems in Peyronie's disease","volume":"5","author":"Smith","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023011909355796700_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ijir.2012.48","article-title":"How curved is too curved? 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