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After 4\u00a0weeks of treatment with dapoxetine 30\u00a0mg as needed, patients with PE underwent the same fMRI examination again 3\u00a0hours after dapoxetine administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>The data were preprocessed using a data processing assistant for resting-state fMRI, and voxelwise amplitude of low-frequency fluctuation (ALFF) maps was calculated to identify abnormal neural activity in the brain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>(a) The ALFF of patients with PE was significantly lower in the bilateral hippocampus and thalamus and higher in the left fusiform and lingual gyrus than that of healthy controls; (b) decreased and increased ALFF in patients with PE recovered after dapoxetine administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We preliminarily identified the relevant sites by analyzing changes in the ALFF in patients with lifelong PE. Analyzing ALFF changes in the brain by resting-state fMRI is an effective method to study PE, and it might provide a reference for disease diagnosis and future research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2020.100287","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T10:45:24Z","timestamp":1611139524000},"page":"100287-100287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in the Amplitude of Low-Frequency Fluctuation in Patients With Lifelong Premature Ejaculation by Resting-State Functional MRI"],"prefix":"10.1093","volume":"9","author":[{"given":"Ma","family":"Yubo","sequence":"first","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi , 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