{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:52:00Z","timestamp":1771487520521,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":719,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Melanotan II, an injectable melanocortin analog, is illicitly available on the internet to generate a sunless tan through melanocyte induction. It is also used as a sexual stimulant in unlicensed performance enhancement clinics, and has been investigated as a possible treatment agent in erectile dysfunction. We describe in this case report a patient presenting with acute ischemic priapism after subcutaneous injection of melanotan II. The patient was initially managed with cavernosal aspiration and irrigation, and intracavernous injection of phenylephrine without achieving detumescence. After failing initial management, the patient underwent operative management with penoscrotal decompression, a promising alternative technique for the management of refractory ischemic priapism. Priapism after melanotan II injection has only been reported in the literature twice before. This case report highlights a rare presentation of acute ischemic priapism after melanotan II use, managed with surgical decompression. Future therapeutic applications of these agents and updated management guidelines should consider priapism as a possible side effect.<\/jats:p>\n                  <jats:p>CW. Mallory, DM Lopategui, BH. Cordon. Melanotan Tanning Injection: A Rare Cause of Priapism. Sex Med 2021;9:100298.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2020.100298","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T14:27:59Z","timestamp":1610720879000},"page":"100298-100298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Melanotan Tanning Injection: A Rare Cause of Priapism"],"prefix":"10.1093","volume":"9","author":[{"given":"Chase W.","family":"Mallory","sequence":"first","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Lopategui","sequence":"additional","affiliation":[{"name":"Division of Urology, Mount Sinai Medical Center , Miami, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy H.","family":"Cordon","sequence":"additional","affiliation":[{"name":"Division of Urology, Mount Sinai Medical Center , Miami, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2023010721371048700_bib1","doi-asserted-by":"crossref","first-page":"e227644","DOI":"10.1136\/bcr-2018-227644","article-title":"Melanotan-induced priapism: a Hard-Earned tan","volume":"12","author":"Dreyer","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2023010721371048700_bib2","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.peptides.2005.01.023","article-title":"Discovery that a melanocortin Regulates sexual functions in male and female Humans","volume":"26","author":"Hadley","year":"2005","journal-title":"Peptides"},{"key":"2023010721371048700_bib3","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3109\/15563650.2012.740637","article-title":"Melanotan II injection resulting in systemic toxicity and Rhabdomyolysis 2012","volume":"50","author":"Nelson","year":"2012","journal-title":"Clin Toxicol"},{"key":"2023010721371048700_bib4","article-title":"Guideline on the management of priapism","volume":"170","author":"Monague","year":"2003","journal-title":"J Urol"},{"key":"2023010721371048700_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bju.15127","article-title":"Favorable multi-institutional experience with penoscrotal decompression for prolonged ischemic priapism","volume":"126","author":"Baumgarten","year":"2020","journal-title":"BJU Int"},{"key":"2023010721371048700_bib6","article-title":"Role of the melanocortin-4 receptor in Hypoactive sexual Desire Disorder","author":"U.S. National Library of Medicine","year":"2019"},{"key":"2023010721371048700_bib7","article-title":"Setmelanotide (RM-493), melanocortin-4 receptor (MCR4) agonist, in Bardet-biedl Syndrome (BBS) and Alstrom Syndrome (AS) patients with Moderate to severe obesity","author":"U.S. National Library of Medicine","year":"2018"}],"container-title":["Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050116120301859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050116120301859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/9\/1\/100298\/48425813\/smoa_9_1_100298.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/9\/1\/100298\/48425813\/smoa_9_1_100298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T21:37:21Z","timestamp":1673127441000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/smoa\/article\/9\/1\/100298\/6956707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.esxm.2020.100298","relation":{},"ISSN":["2050-1161"],"issn-type":[{"value":"2050-1161","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melanotan Tanning Injection: A Rare Cause of Priapism","name":"articletitle","label":"Article Title"},{"value":"Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esxm.2020.100298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the International Society for Sexual Medicine.","name":"copyright","label":"Copyright"}]}}