{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:41Z","timestamp":1783113941709,"version":"3.54.6"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":647,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["smoa.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Previous studies have indicated that low-intensity extracorporeal shockwave therapy (Li-ESWT) may improve male erectile dysfunction (ED) of vascular aetiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate penile rehabilitation of Li-ESWT in a randomized, placebo-controlled trial in men with ED following robotic nerve-sparing radical prostatectomy (RARP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Included were men with ED following nerve-sparing RP with a score &amp;lt;22 in the 5-item International Index of Erectile Function (IIEF-5) questionnaire. Participants were divided into an active A (n\u00a0=\u00a020) and a placebo\/sham B group (n\u00a0=\u00a018). They were randomized consecutively upon study entry. Each study arm had one treatment a week for 5 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Sexual outcomes were assessed by international validated questionnaires, Erection Hardness Score (EHS) and IIEF-5 at baseline and at 4 and 12 weeks after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 38 (n\u00a0=\u00a038) participants were enrolled; there were no dropouts. A significant increase was observed in IIEF-5 and EHS in group A at both 4 and 12 weeks. At 12 weeks, the mean IIEF-5 score had increased by 3.45 points (P = .026), while the mean EHS score had increased by 0.5 points (P= .019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This randomized study indicates that Li-ESWT for ED in men undergone RP might be effective and safe. However, further and more robust research is needed before Li-ESWT can be characterized as a reliable treatment modality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.esxm.2021.100338","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T08:49:42Z","timestamp":1616921382000},"page":"100338-100338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Erectile Dysfunction A Prospective Randomized Placebo-Controlled Study Evaluating the Effect of Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT) in Men With Erectile Dysfunction Following Radical Prostatectomy"],"prefix":"10.1093","volume":"9","author":[{"given":"Peter Bill Juul","family":"Ladegaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune M\u00f8ller","family":"Skov-Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"2023012006410143600_bib1","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3390\/ijms18081794","article-title":"Neuroprotective and nerve regenerative approaches for treatment of erectile dysfunction after cavernous nerve injury","volume":"18","author":"Campbell","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2023012006410143600_bib2","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1097\/01.ju.0000154356.76027.4f","article-title":"Histological alterations in cavernous tissue after radical prostatectomy","volume":"173","author":"Iacono","year":"2005","journal-title":"J Urol"},{"key":"2023012006410143600_bib3","article-title":"Robotic-assisted radical prostatectomy after the first decade: surgical evolution or new paradigm","volume":"2013","author":"Skarecky","year":"2013","journal-title":"ISRN Urol"},{"key":"2023012006410143600_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11701-016-0607-7","article-title":"Current status of various neurovascular bundle-sparing techniques in robot-assisted radical prostatectomy","volume":"10","author":"Kumar","year":"2016","journal-title":"J Robot Surg"},{"key":"2023012006410143600_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.eururo.2015.02.029","article-title":"Urinary incontinence and erectile dysfunction after robotic versus open radical prostatectomy: a prospective, controlled, nonrandomised trial","volume":"68","author":"Haglind","year":"2015","journal-title":"Eur Urol"},{"key":"2023012006410143600_bib6","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1016\/j.esxm.2017.06.003","article-title":"A retrospective study of erectile function and use of erectile aids in prostate cancer patients after radical prostatectomy in denmark","volume":"5","author":"Haahr","year":"2017","journal-title":"Sex Med"},{"key":"2023012006410143600_bib7","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1111\/j.1743-6109.2009.01351.x","article-title":"Erectile function recovery rate after radical prostatectomy: a meta-analysis","volume":"6","author":"Tal","year":"2009","journal-title":"J Sex Med"},{"key":"2023012006410143600_bib8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/j.1464-410X.2010.09231.x","article-title":"Changes in specific domains of sexual function and sexual bother after radical prostatectomy","volume":"106","author":"Le","year":"2010","journal-title":"BJU Int"},{"key":"2023012006410143600_bib9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJM199805143382001","article-title":"Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group","volume":"338","author":"Goldstein","year":"1998","journal-title":"N Engl J Med"},{"key":"2023012006410143600_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.eururo.2013.09.051","article-title":"Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT)","volume":"65","author":"Montorsi","year":"2014","journal-title":"Eur Urol"},{"key":"2023012006410143600_bib11","doi-asserted-by":"crossref","first-page":"e91327","DOI":"10.1371\/journal.pone.0091327","article-title":"Systematic review and meta-analysis of the use of phosphodiesterase type 5 inhibitors for treatment of erectile dysfunction following bilateral nerve-sparing radical prostatectomy","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"2023012006410143600_bib12","doi-asserted-by":"crossref","first-page":"21C","DOI":"10.1016\/S0002-9149(99)00044-2","article-title":"Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist","volume":"83","author":"Webb","year":"1999","journal-title":"Am J Cardiol"},{"key":"2023012006410143600_bib13","first-page":"13","article-title":"Erectile dysfunction post-radical prostatectomy - a challenge for both patient and physician","volume":"10","author":"Bratu","year":"2017","journal-title":"J Med Life"},{"key":"2023012006410143600_bib14","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1111\/j.1743-6109.2011.02466.x","article-title":"Erectile function and sexual satisfaction before and after penile prosthesis implantation in radical prostatectomy patients: a comparison with patients with vasculogenic erectile dysfunction","volume":"8","author":"Menard","year":"2011","journal-title":"J Sex Med"},{"key":"2023012006410143600_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5534\/wjmh.2016.34.3.155","article-title":"The current status of stem-cell therapy in erectile dysfunction: a review","volume":"34","author":"Reed-Maldonado","year":"2016","journal-title":"World J Mens Health"},{"key":"2023012006410143600_bib16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ebiom.2016.01.024","article-title":"Safety and potential effect of a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy: an open-label phase I clinical trial","author":"Haahr MK","year":"2016","journal-title":"EBioMedicine"},{"key":"2023012006410143600_bib17","first-page":"1","article-title":"Erectile dysfunction treatment using focused linear low-intensity extracorporeal shockwaves: single-blind, sham-controlled, randomized clinical trial","author":"Sramkova","year":"2019","journal-title":"Urol Int"},{"key":"2023012006410143600_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/21681805.2014.984326","article-title":"Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, double-blind, placebo-controlled study","volume":"49","author":"Olsen","year":"2015","journal-title":"Scand J Urol"},{"key":"2023012006410143600_bib19","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.juro.2011.12.117","article-title":"Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study","volume":"187","author":"Vardi","year":"2012","journal-title":"J Urol"},{"key":"2023012006410143600_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41443-019-0117-z","article-title":"Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials","volume":"31","author":"Sokolakis","year":"2019","journal-title":"Int J Impot Res"},{"key":"2023012006410143600_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eururo.2016.05.050","article-title":"Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis","volume":"71","author":"Lu","year":"2017","journal-title":"Eur Urol"},{"key":"2023012006410143600_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/21681805.2015.1100675","article-title":"Low-intensity extracorporeal shockwave therapy in the treatment of postprostatectomy erectile dysfunction: a pilot study","volume":"50","author":"Frey","year":"2016","journal-title":"Scand J Urol"},{"key":"2023012006410143600_bib23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/jsm.12024","article-title":"Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model","volume":"10","author":"Qiu","year":"2013","journal-title":"J Sex Med"},{"key":"2023012006410143600_bib24","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.juro.2015.12.049","article-title":"Penile low intensity shock wave treatment is able to shift pde5i nonresponders to responders: a double-blind, sham controlled study","volume":"195","author":"Kitrey","year":"2016","journal-title":"J Urol"},{"key":"2023012006410143600_bib25","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.eururo.2011.07.053","article-title":"Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale","volume":"60","author":"Rosen","year":"2011","journal-title":"Eur Urol"},{"key":"2023012006410143600_bib26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5534\/wjmh.190130","article-title":"Electromagnetic low-intensity extracorporeal shock wave therapy in patients with erectile dysfunction: a sham-controlled, double-blind, randomized prospective study","volume":"38","author":"Kim","year":"2020","journal-title":"World J Mens Health"},{"key":"2023012006410143600_bib27","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s11255-018-1987-6","article-title":"Efficacy and safety of low-intensity shock wave therapy in penile rehabilitation post nerve-sparing radical cystoprostatectomy: a randomized controlled trial","volume":"50","author":"Zewin","year":"2018","journal-title":"Int Urol Nephrol"},{"key":"2023012006410143600_bib28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/iju.12506","article-title":"Extracorporeal shockwave therapy in the treatment of erectile dysfunction: a prospective, randomized, double-blinded, placebo controlled study","volume":"21","author":"Yee","year":"2014","journal-title":"Int J Urol"},{"key":"2023012006410143600_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jsxm.2016.11.307","article-title":"Effect of low-energy linear shockwave therapy on erectile dysfunction-a double-blinded, sham-controlled, randomized clinical trial","volume":"14","author":"Fojecki","year":"2017","journal-title":"J Sex Med"}],"container-title":["Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050116121000180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2050116121000180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/9\/3\/100338\/48793629\/smoa_9_3_100338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/smoa\/article-pdf\/9\/3\/100338\/48793629\/smoa_9_3_100338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:41:52Z","timestamp":1674196912000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/smoa\/article\/9\/3\/100338\/6956877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,28]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.esxm.2021.100338","relation":{},"ISSN":["2050-1161"],"issn-type":[{"value":"2050-1161","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6]]},"published":{"date-parts":[[2021,3,28]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Erectile Dysfunction A Prospective Randomized Placebo-Controlled Study Evaluating the Effect of Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT) in Men With Erectile Dysfunction Following Radical Prostatectomy","name":"articletitle","label":"Article Title"},{"value":"Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.esxm.2021.100338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the International Society for Sexual Medicine.","name":"copyright","label":"Copyright"}]}}