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On the other hand, the analysis of data from 3 studies describing serum leptin levels in PE patients before and after treatment with selective serotonin reuptake inhibitors (SSRIs) showed that there was a significant decrease with leptin levels in PE patients after treatment (WMD (95%CI)\u00a0=\u00a022.06 (17.21, 26.92), P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>It is possible that leptin can be used as a new marker for premature ejaculation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strength &amp; Limitations<\/jats:title>\n                    <jats:p>The strength of this study is that it is the first meta- analysis to assess the differences of serum leptin levels between patients with premature ejaculation and healthy subjects and the changes of leptin levels before and after treatment in patients with premature ejaculation. A major limitation is that a greater heterogeneity was identified through our analysis, however we did not find a definitive source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a statistically significant relationship between serum leptin levels and patients with PE. In addition, serum leptin levels in patients with PE decreased significantly after 8 weeks of treatment with SSRIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.esxm.2022.100509","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T13:56:07Z","timestamp":1649339767000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Marker for Premature Ejaculation: Serum Leptin Level"],"prefix":"10.1093","volume":"10","author":[{"given":"Guodong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, Hospital of Anhui Medical University , China"},{"name":"Institute of Urology, Hospital of Anhui Medical University , China"},{"name":"Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University , 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Urology, Hospital of Anhui Medical University , China"},{"name":"Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital of Anhui Medical University , China"},{"name":"Institute of Urology, Hospital of Anhui Medical University , China"},{"name":"Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Third Hospital , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Andrology, Drum Tower Hospital, Medical School of Nanjing University , Nanjing , 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