{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:54:44Z","timestamp":1765230884624,"version":"3.33.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.etap.2008.02.006","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T00:55:41Z","timestamp":1203987341000},"page":"102-108","source":"Crossref","is-referenced-by-count":22,"title":["Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2"],"prefix":"10.1016","volume":"26","author":[{"given":"Heleen M.","family":"Wortelboer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel G.J.","family":"Balvers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Usta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"van Bladeren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole H.P.","family":"Cnubben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2008.02.006_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tox.2004.07.003","article-title":"Endogenous thiols and MRP transporters contribute to Hg2+ efflux in HgCl2-treated tubular MDCK cells","volume":"206","author":"Aleo","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2008.02.006_bib2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione and glutathione disulfide in biological samples","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2008.02.006_bib3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.02110s5689","article-title":"Transport of toxic metals by molecular mimicry","volume":"110","author":"Ballatori","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2008.02.006_bib4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0272-0590(85)90165-4","article-title":"Biliary secretion of glutathione and of glutathione\u2013metal complexes","volume":"5","author":"Ballatori","year":"1985","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.etap.2008.02.006_bib5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.taap.2004.09.008","article-title":"Molecular mechanisms of reduced glutathione transport: role of the MRP\/CFTR\/ABCC and OATP\/SLC21A families of membrane proteins","volume":"204","author":"Ballatori","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2008.02.006_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-4347(95)00098-4","article-title":"Characterization of cisplatin\u2013glutathione adducts by liquid chromatography\u2013mass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats and cancer patients","volume":"669","author":"Bernareggi","year":"1995","journal-title":"J. Chromatogr. Biomed. Appl."},{"key":"10.1016\/j.etap.2008.02.006_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-4274(85)90046-3","article-title":"Toxicity determined in vitro by morphological alterations and neutral red absorption","volume":"24","author":"Borenfreund","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2008.02.006_bib8","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jnci\/92.16.1295","article-title":"A family of drug transporters: the multidrug resistance-associated proteins","volume":"92","author":"Borst","year":"2000","journal-title":"Natl. Cancer Inst."},{"key":"10.1016\/j.etap.2008.02.006_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.biochem.71.102301.093055","article-title":"Mammalian ABC transporters in health and disease","volume":"71","author":"Borst","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.etap.2008.02.006_bib10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.febslet.2005.12.039","article-title":"On the putative co-transport of drugs by multidrug resistance proteins","volume":"580","author":"Borst","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.etap.2008.02.006_bib11","doi-asserted-by":"crossref","first-page":"30962","DOI":"10.1074\/jbc.272.49.30962","article-title":"ATPase activity of purified multidrug resistance-associated protein","volume":"272","author":"Chang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib12","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0002-9440(10)61234-5","article-title":"Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2","volume":"167","author":"Ciarimboli","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.etap.2008.02.006_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1517\/17425255.1.2.219","article-title":"Metabolism of ABC drug transporter inhibitors; complicating factor for multidrug resistance","volume":"1","author":"Cnubben","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.etap.2008.02.006_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tox.2004.09.002","article-title":"Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats","volume":"207","author":"Csanaky","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2008.02.006_bib15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0026-895X(24)23190-4","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.etap.2008.02.006_bib16","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1124\/dmd.30.12.1378","article-title":"Kinetic study of the reaction of cisplatin with thiols","volume":"30","author":"Dabrowiak","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.etap.2008.02.006_bib17","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.febslet.2005.12.036","article-title":"Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)","volume":"580","author":"Deeley","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.etap.2008.02.006_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0009-2797(94)90099-X","article-title":"Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study","volume":"90","author":"Delnomdedieu","year":"1994","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2008.02.006_bib19","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI119886","article-title":"Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA","volume":"101","author":"Evers","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.etap.2008.02.006_bib20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1054\/bjoc.2000.1260","article-title":"Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2 mediated transport","volume":"83","author":"Evers","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.etap.2008.02.006_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-4347(98)00282-5","article-title":"On-column formation of arsenic-glutathione species detected by size-exclusion chromatography in conjunction with arsenic-specific detectors","volume":"716","author":"Gailer","year":"1998","journal-title":"J. Chromatogr. Biomed. Sci. Appl."},{"key":"10.1016\/j.etap.2008.02.006_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ygyno.2005.08.046","article-title":"MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma","volume":"100","author":"Guminski","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.etap.2008.02.006_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/00003495-200059004-00002","article-title":"Clinical perspectives on platinum resistance","volume":"59","author":"Giaccone","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.etap.2008.02.006_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/10715769900301121","article-title":"Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells","volume":"31","author":"Goto","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.etap.2008.02.006_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1124\/jpet.103.059410","article-title":"Kinetic study on the reactions of platinum drugs with glutathione","volume":"308","author":"Hagrman","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.etap.2008.02.006_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1389200043489199","article-title":"The MRP-related and BCRP\/ABCG2 multidrug resistance proteins: biology, substrate and regulation","volume":"5","author":"Haimeur","year":"2004","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.etap.2008.02.006_bib27","first-page":"2532","article-title":"Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2","volume":"59","author":"Hooijberg","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2008.02.006_bib28","doi-asserted-by":"crossref","first-page":"14981","DOI":"10.1074\/jbc.271.25.14981","article-title":"Coordinated induction of MRP\/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells","volume":"271","author":"Ishikawa","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib29","first-page":"1649","article-title":"Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells","volume":"22","author":"Itoh","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1016\/j.etap.2008.02.006_bib30","doi-asserted-by":"crossref","first-page":"33404","DOI":"10.1074\/jbc.M007030200","article-title":"The MRP2\/cMOAT transporter and arsenic\u2013glutathione complex formation are required for biliary excretion of arsenic","volume":"275","author":"Kala","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0300-483X(01)00570-4","article-title":"Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression","volume":"171","author":"Kauffmann","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2008.02.006_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1124\/dmd.31.1.11","article-title":"Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)","volume":"31","author":"Leslie","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.etap.2008.02.006_bib33","doi-asserted-by":"crossref","first-page":"32700","DOI":"10.1074\/jbc.M404912200","article-title":"Arsenic transport by the human multidrug resistance protein 1 (MRP1\/ABCC1): evidence that a tri-glutathione conjugate is required","volume":"279","author":"Leslie","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib34","doi-asserted-by":"crossref","first-page":"27846","DOI":"10.1074\/jbc.M102453200","article-title":"Transport of the beta-O-Glucuronide conjugate of the tobacco-specific carcinogen 4-methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). requirement for glutathione or a non-sulfur containing analog","volume":"276","author":"Leslie","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib35","doi-asserted-by":"crossref","first-page":"9675","DOI":"10.1074\/jbc.271.16.9675","article-title":"Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport","volume":"271","author":"Loe","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib36","first-page":"5130","article-title":"Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione","volume":"58","author":"Loe","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2008.02.006_bib37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0022-3565(24)39265-1","article-title":"Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)","volume":"293","author":"Loe","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.etap.2008.02.006_bib38","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1006\/bbrc.2000.3384","article-title":"Structure\u2013activity studies of verapamil analogs that modulate transport of leukotriene C4 and reduced glutathione by multidrug resistance protein MRP1","volume":"275","author":"Loe","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2008.02.006_bib39","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0022-3565(24)29270-3","article-title":"Rational use of in vitro P-glycoprotein assays in drug discovery","volume":"299","author":"Polli","year":"2001","journal-title":"J. Pharmcol. Exp. Ther."},{"key":"10.1016\/j.etap.2008.02.006_bib40","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1074\/jbc.M008251200","article-title":"Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1","volume":"276","author":"Qian","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00689042","article-title":"Intracellular glutathione and cytotoxicity of platinum complexes","volume":"36","author":"Pendyala","year":"1995","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.etap.2008.02.006_bib42","first-page":"5232","article-title":"Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins","volume":"57","author":"Rappa","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2008.02.006_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1015180026665","article-title":"The MRP1-mediated effluxes of arsenic and antimony do not require arsenic\u2013glutathione and antimony\u2013glutathione complex formation","volume":"34","author":"Salerno","year":"2002","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.etap.2008.02.006_bib44","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/S0021-9258(18)42909-2","article-title":"Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase","volume":"267","author":"Sarkadi","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2008.02.006_bib45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/bjc.1998.461","article-title":"Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines","volume":"78","author":"Sharp","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.etap.2008.02.006_bib46","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood.V89.9.3354","article-title":"Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL). II. Clinical efficacy and pharmacokinetics in relapsed patients","volume":"9","author":"Shen","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.etap.2008.02.006_bib47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0300-483X(99)00148-1","article-title":"Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals","volume":"142","author":"Vernhet","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2008.02.006_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0162-0134(98)10084-3","article-title":"Preparation, 195Pt NMR spectra and biological activity of platinum (IV) complexes with dipeptides","volume":"73","author":"Watabe","year":"1999","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.etap.2008.02.006_bib49","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1021\/tx034101x","article-title":"Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin","volume":"16","author":"Wortelboer","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.etap.2008.02.006_bib50","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.bcp.2005.04.001","article-title":"Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha, beta-unsaturated carbonyl compounds","volume":"69","author":"Wortelboer","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2008.02.006_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0031-6997(24)01438-8","article-title":"Molecular interactions with mercury in the kidney","volume":"52","author":"Zalups","year":"2000","journal-title":"Pharmacol. Rev."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668908000392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668908000392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T19:22:17Z","timestamp":1738092137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668908000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1382668908000392"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2008.02.006","relation":{},"ISSN":["1382-6689"],"issn-type":[{"type":"print","value":"1382-6689"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}