{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:03:38Z","timestamp":1762297418138},"reference-count":97,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.etap.2009.02.005","type":"journal-article","created":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T12:06:31Z","timestamp":1235304391000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["About coffee, cappuccino and connective tissue growth factor\u2014Or how to protect your liver!?"],"prefix":"10.1016","volume":"28","author":[{"given":"Olav A.","family":"Gressner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2009.02.005_bib1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ncb826","article-title":"Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta","volume":"4","author":"Abreu","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.etap.2009.02.005_bib2","first-page":"1","article-title":"Deaths: leading causes for 2001","volume":"52","author":"Anderson","year":"2003","journal-title":"Natl. Vital. Stat. Rep."},{"key":"10.1016\/j.etap.2009.02.005_bib3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/PL00000758","article-title":"Regulation of gene expression by transcription factor acetylation","volume":"57","author":"Bannister","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0278-6915(95)00093-3","article-title":"Caffeine consumption","volume":"34","author":"Barone","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2009.02.005_bib5","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1097\/01.ASN.0000025282.48298.7B","article-title":"The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease","volume":"13","author":"Belibi","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.etap.2009.02.005_bib6","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2001.28457","article-title":"Transforming growth factor beta and the liver","volume":"34","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1365-2141.2007.06739.x","article-title":"High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia","volume":"138","author":"Boag","year":"2007","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.etap.2009.02.005_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0968-0004(99)01516-9","article-title":"The many HATs of transcription coactivators","volume":"25","author":"Brown","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1286-4579(99)00255-5","article-title":"TGF-beta1: immunosuppressant and viability factor for T lymphocytes","volume":"1","author":"Cerwenka","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1016\/j.etap.2009.02.005_bib10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0955-0674(00)00200-3","article-title":"HATs on and beyond chromatin","volume":"13","author":"Chen","year":"2001","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.etap.2009.02.005_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08977190412331279890","article-title":"Bone morphogenetic proteins","volume":"22","author":"Chen","year":"2004","journal-title":"Growth Factors"},{"key":"10.1016\/j.etap.2009.02.005_bib12","series-title":"Caffeine, Coffee and Health","first-page":"97","article-title":"Mechanism of action of caffeine","author":"Daly","year":"1993"},{"key":"10.1016\/j.etap.2009.02.005_bib13","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1096\/fasebj.13.13.1774","article-title":"Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP","volume":"13","author":"Duncan","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.etap.2009.02.005_bib14","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.1074\/jbc.C100008200","article-title":"Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation","volume":"276","author":"Ebisawa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib15","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1200\/JCO.2005.02.047","article-title":"Role of transforming growth factor Beta in human cancer","volume":"23","author":"Elliott","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.etap.2009.02.005_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1007976831684","article-title":"Recent advances in caffeine and theobromine toxicities: a review","volume":"51","author":"Eteng","year":"1997","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.etap.2009.02.005_bib17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00018-003-3269-3","article-title":"Caffeine as a psychomotor stimulant: mechanism of action","volume":"61","author":"Fisone","year":"2004","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib18","doi-asserted-by":"crossref","first-page":"40341","DOI":"10.1074\/jbc.M605077200","article-title":"Depletion of cAMP-response element-binding protein\/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT\/enhancer-binding protein (C\/EBP) alpha, C\/EBP beta, or PPAR gamma 2","volume":"281","author":"Fox","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib19","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.etap.2009.02.005_bib21","doi-asserted-by":"crossref","first-page":"45888","DOI":"10.1074\/jbc.M105490200","article-title":"Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3","volume":"276","author":"Fu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2125.1999.00890.x","article-title":"Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism","volume":"47","author":"Gates","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.etap.2009.02.005_bib23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.gt.3302929","article-title":"siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats","volume":"14","author":"George","year":"2007","journal-title":"Gene Ther."},{"key":"10.1016\/j.etap.2009.02.005_bib24","first-page":"92","article-title":"Mediators of hepatic fibrogenesis","volume":"43","author":"Gressner","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib25","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1478-3231.2008.01826.x","article-title":"Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases","volume":"28","author":"Gressner","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.etap.2009.02.005_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1053\/jhep.1996.v23.pm0008617439","article-title":"Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta","volume":"23","author":"Gressner","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib27","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0168-8278(97)80117-1","article-title":"TGF-beta-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes","volume":"26","author":"Gressner","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib28","doi-asserted-by":"crossref","first-page":"d793","DOI":"10.2741\/gressner","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front Biosci."},{"key":"10.1016\/j.etap.2009.02.005_bib29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jhep.2007.05.015","article-title":"Differential effects of TGF-beta on connective tissue growth factor (CTGF\/CCN2) expression in hepatic stellate cells and hepatocytes","volume":"47","author":"Gressner","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib30","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/j.1440-1746.2008.05345.x","article-title":"Changing the pathogenetic roadmap of liver fibrosis?","volume":"23","author":"Gressner","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib31","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/j.1582-4934.2008.00260.x","article-title":"Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor","volume":"12","author":"Gressner","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.etap.2009.02.005_bib32","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/j.1478-3231.2008.01729.x","article-title":"Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF\/CCN2) expression","volume":"28","author":"Gressner","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.etap.2009.02.005_bib33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jhep.2008.03.029","article-title":"Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and Smad2\/3-dependent pathways","volume":"49","author":"Gressner","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib34","doi-asserted-by":"crossref","unstructured":"Gressner, O.A., Gao, C.F., Rehbein, K., et al. Elevated concentrations of 15-deoxy-\u039412,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with PPARgamma inducing drugs. Liver Int., doi:10.1111\/j.1478-3231.2008.01895.x, in press-a.","DOI":"10.1111\/j.1478-3231.2008.01895.x"},{"key":"10.1016\/j.etap.2009.02.005_bib35","doi-asserted-by":"crossref","unstructured":"Gressner, O.A., Siluschek, M., Lahme, B., Gressner, A.M. Intraperitoneal application of caffeine prevents d-galactosamine induced hepatic expression of connective tissue growth factor (CTGF\/CCN2) in the rat. J. Hepatol., doi:10.1016\/j.jhep.2009.02.001, in press-b.","DOI":"10.1016\/j.jhep.2009.02.001"},{"key":"10.1016\/j.etap.2009.02.005_bib36","doi-asserted-by":"crossref","unstructured":"Gressner, O.A., Lahme, B., Siluschek, M., et al. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor-beta actions in hepatocytes\u2014but without modulating bone morphogenetic protein 7 signalling. Hepatology, 49 2009, doi:10.1002\/hep.22850.","DOI":"10.1002\/hep.22850"},{"key":"10.1016\/j.etap.2009.02.005_bib37","doi-asserted-by":"crossref","unstructured":"Gressner OA, Lahme B, Rehbein K, Siluschek M, Gressner AM. Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells. Liver Int., doi:10.1111\/j.1478-3231.2009.01987.x, in press-c.","DOI":"10.1111\/j.1478-3231.2009.01987.x"},{"key":"10.1016\/j.etap.2009.02.005_bib38","first-page":"133","article-title":"Connective tissue growth factor is directly related to liver fibrosis","volume":"49","author":"Hayashi","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib39","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1476-5926-2-S1-S7","article-title":"PPAR gamma and hepatic stellate cells","volume":"1","author":"Hazra","year":"2004","journal-title":"Comp. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib40","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1681\/ASN.V1291853","article-title":"Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP","volume":"12","author":"Heusinger-Ribeiro","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.etap.2009.02.005_bib41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jcb.20558","article-title":"TGF-beta control of cell proliferation","volume":"96","author":"Huang","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.etap.2009.02.005_bib42","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.etap.2009.02.005_bib43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2005.08.070","article-title":"Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice","volume":"336","author":"Inoue","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2009.02.005_bib44","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.metabol.2003.08.004","article-title":"Studies on the mechanism of caffeine action in alveolar macrophages: caffeine elevates cyclic adenosine monophosphate level and prostaglandin synthesis","volume":"53","author":"Jafari","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.etap.2009.02.005_bib45","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1007\/s00018-005-4533-5","article-title":"Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development","volume":"62","author":"Jeon","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib46","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.3748\/wjg.v13.i39.5208","article-title":"CTGF, intestinal stellate cells and carcinoid fibrogenesis","volume":"13","author":"Kidd","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.etap.2009.02.005_bib47","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1096\/fasebj.12.12.1151","article-title":"Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle","volume":"12","author":"Kothapalli","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.etap.2009.02.005_bib48","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation: a regulatory modification to rival phosphorylation?","volume":"19","author":"Kouzarides","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.etap.2009.02.005_bib49","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.bjc.6602737","article-title":"Coffee and risk of death from hepatocellular carcinoma in a large cohort study in Japan","volume":"93","author":"Kurozawa","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.etap.2009.02.005_bib50","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2007.03.044","article-title":"Coffee consumption and risk of liver cancer: a meta-analysis","volume":"132","author":"Larsson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib51","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1038\/sj.onc.1209091","article-title":"Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3\u2032 kinase\/AKT pathways","volume":"24","author":"Larue","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.etap.2009.02.005_bib52","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1242\/jcs.03270","article-title":"All in the CCN family: essential matricellular signaling modulators emerge from the bunker","volume":"119","author":"Leask","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib53","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/mp.54.3.180","article-title":"The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts","volume":"54","author":"Leask","year":"2001","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.etap.2009.02.005_bib54","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jgm.894","article-title":"Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats","volume":"8","author":"Li","year":"2006","journal-title":"J. Gene Med."},{"key":"10.1016\/j.etap.2009.02.005_bib55","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.3748\/wjg.14.2110","article-title":"Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer","volume":"14","author":"Liu","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.etap.2009.02.005_bib56","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/70258","article-title":"Ubiquitin-dependent degradation of TGF-beta-activated smad2","volume":"1","author":"Lo","year":"1999","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.etap.2009.02.005_bib57","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/PL00000893","article-title":"Structure and function of histone acetyltransferases","volume":"58","author":"Marmorstein","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0959-437X(00)00173-8","article-title":"Histone acetyltransferases: function, structure, and catalysis","volume":"11","author":"Marmorstein","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.etap.2009.02.005_bib59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)00121-5","article-title":"TGFbeta signaling in growth control, cancer, and heritable disorders","volume":"103","author":"Massague","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.etap.2009.02.005_bib60","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.etap.2009.02.005_bib61","first-page":"835A","article-title":"Higher caffeine consumption is associated with milder fibrosis in patients with chronic liver diseases","volume":"46","author":"Modi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib62","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1146\/annurev.biochem.66.1.807","article-title":"Transcriptional regulation by cyclic AMP","volume":"66","author":"Montminy","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.etap.2009.02.005_bib63","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/mgme.2000.3059","article-title":"Connective tissue growth factor: what's in a name?","volume":"71","author":"Moussad","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.etap.2009.02.005_bib64","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/jcp.2007.052795","article-title":"Expression of connective tissue growth factor (CTGF\/CCN2) in head and neck squamous cell carcinoma","volume":"61","author":"Mullis","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.etap.2009.02.005_bib65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2141.2007.06721.x","article-title":"Connective tissue growth factor is an indicator of bone involvement in multiple myeloma, but matrix metalloproteinase-9 is not","volume":"139","author":"Munemasa","year":"2007","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.etap.2009.02.005_bib66","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1440-1746.1998.tb00713.x","article-title":"Plasma transforming growth factor-beta 1 concentrations in patients with chronic viral hepatitis","volume":"13","author":"Murawaki","year":"1998","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.etap.2009.02.005_bib67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00609587","article-title":"Plasma and salivary pharmacokinetics of caffeine in man","volume":"21","author":"Newton","year":"1981","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.etap.2009.02.005_bib68","unstructured":"National Fire Protection Association\u2014Hazardous Materials Classification, 2008. [cited; Available from: www.nfpa.org\/index.asp]."},{"key":"10.1016\/j.etap.2009.02.005_bib69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/hep.21466","article-title":"Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation","volume":"45","author":"Nguyen","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib70","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1681\/ASN.2007111261","article-title":"CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy","volume":"19","author":"Nguyen","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.etap.2009.02.005_bib71","unstructured":"National Paint and Coatings Association\u2014Hazardous Materials Information System\u00ae III (HMIS\u00ae III), 2008. [cited; Available from: www.paint.org\/hmis\/index.cfm]."},{"key":"10.1016\/j.etap.2009.02.005_bib72","first-page":"2478","article-title":"Effect of transforming growth factor beta on cell death of cultured rat hepatocytes","volume":"51","author":"Oberhammer","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2009.02.005_bib73","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/PL00000892","article-title":"Mammalian histone acetyltransferases and their complexes","volume":"58","author":"Ogryzko","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.etap.2009.02.005_bib74","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","article-title":"Expression of connective tissue growth factor in experimental rat and human liver fibrosis","volume":"30","author":"Paradis","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dld.2004.01.003","article-title":"Liver fibrosis: from the bench to clinical targets","volume":"36","author":"Pinzani","year":"2004","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.etap.2009.02.005_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1386-6346(03)00115-3","article-title":"Connective tissue growth factor (CTGF\/CCN2) in hepatic fibrosis","volume":"26","author":"Rachfal","year":"2003","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.etap.2009.02.005_bib77","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0083-6729(05)70003-0","article-title":"Structural and functional properties of CCN proteins","volume":"70","author":"Rachfal","year":"2005","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.etap.2009.02.005_bib78","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/bbrc.1994.1738","article-title":"Caffeine biotransformation in human hepatocyte lines derived from normal liver tissue","volume":"201","author":"Roberts","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2009.02.005_bib79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.etap.2009.02.005_bib80","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2004.09.075","article-title":"Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States","volume":"128","author":"Ruhl","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib81","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1053\/j.gastro.2005.08.056","article-title":"Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States","volume":"129","author":"Ruhl","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2009.02.005_bib82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1357-2725(97)00093-9","article-title":"Coupling gene expression to cAMP signalling: role of CREB and CREM","volume":"30","author":"Sassone-Corsi","year":"1998","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.etap.2009.02.005_bib83","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ijc.20989","article-title":"Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan","volume":"116","author":"Shimazu","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.etap.2009.02.005_bib84","doi-asserted-by":"crossref","first-page":"39870","DOI":"10.1074\/jbc.M607868200","article-title":"The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation","volume":"281","author":"Simonsson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib85","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1745-7254.2006.00299.x","article-title":"PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression","volume":"27","author":"Sun","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.etap.2009.02.005_bib86","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/ije\/27.3.438","article-title":"Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers","volume":"27","author":"Tanaka","year":"1998","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.etap.2009.02.005_bib87","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01740665","article-title":"Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations","volume":"43","author":"Ullrich","year":"1992","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.etap.2009.02.005_bib88","series-title":"The World of Caffeine: The Science and Culture of the World's Most Popular Drug","author":"Weinberg","year":"2000"},{"key":"10.1016\/j.etap.2009.02.005_bib89","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/hep.21806","article-title":"Profibrogenic transforming growth factor-beta\/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes","volume":"46","author":"Weng","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2009.02.005_bib90","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/BST0340761","article-title":"Reversible ubiquitination regulates the Smad\/TGF-beta signalling pathway","volume":"34","author":"Wicks","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.etap.2009.02.005_bib91","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1158\/0008-5472.CAN-06-1308","article-title":"Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3","volume":"66","author":"Yang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2009.02.005_bib92","doi-asserted-by":"crossref","first-page":"40650","DOI":"10.1074\/jbc.M510094200","article-title":"Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells","volume":"280","author":"Yavrom","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib93","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.emboj.7600069","article-title":"Integration of TGF-beta\/Smad and Jagged1\/Notch signalling in epithelial-to-mesenchymal transition","volume":"23","author":"Zavadil","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.etap.2009.02.005_bib94","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.etap.2009.02.005_bib95","doi-asserted-by":"crossref","first-page":"23337","DOI":"10.1074\/jbc.M700194200","article-title":"Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition","volume":"282","author":"Zeisberg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2009.02.005_bib96","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1073\/pnas.98.3.974","article-title":"Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase","volume":"98","author":"Zhang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.etap.2009.02.005_bib97","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbrc.2006.09.069","article-title":"PPARgamma agonists prevent TGFbeta1\/Smad3-signaling in human hepatic stellate cells","volume":"350","author":"Zhao","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668909000350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668909000350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T05:49:26Z","timestamp":1633153766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668909000350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1382668909000350"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2009.02.005","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}