{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:55Z","timestamp":1791230935687,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.etap.2013.09.021","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:10:36Z","timestamp":1381536636000},"page":"1150-1166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: Reversal effect of essential metals and a chelating agent"],"prefix":"10.1016","volume":"36","author":[{"given":"Praveen Kumar","family":"Kadeyala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saritha","family":"Sannadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarami Reddy","family":"Gottipolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2013.09.021_bib0005","first-page":"265","article-title":"Biochemical toxicology of arsenic","volume":"10","author":"Aposhian","year":"1989","journal-title":"Rev. Biochem. Toxicol."},{"issue":"1","key":"10.1016\/j.etap.2013.09.021_bib0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/15287398509530726","article-title":"The effect of dietary calcium on lead absorption, distribution and elimination kinetics in rats","volume":"16","author":"Aungst","year":"1985","journal-title":"J. Toxicol. Health"},{"key":"10.1016\/j.etap.2013.09.021_bib0015","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0076-6879(57)03493-X","article-title":"Determination of metals","volume":"3","author":"Ballentine","year":"1957","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2013.09.021_bib0020","first-page":"366","article-title":"Effect of calcium on the absorption and retention of lead","volume":"91","author":"Barton","year":"1978","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.etap.2013.09.021_bib0025","first-page":"37","article-title":"Glutathione, iron and Parkinson's disease","volume":"10","author":"Bharath","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2013.09.021_bib0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.etap.2009.03.012","article-title":"Oral co-administration of lipoic acid, quercetin and captopril prevents gallium arsenide toxicity in rats","volume":"28","author":"Bhatt","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2013.09.021_bib0035","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.etap.2012.02.003","article-title":"Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats","volume":"33","author":"Bhattacharyaa","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2013.09.021_bib0040","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.2174\/138161210793176563","article-title":"Cell death targets and potential modulators in Alzheimer's disease","volume":"16","author":"Castro","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.etap.2013.09.021_bib0045","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0076-6879(55)02300-8","article-title":"Assay of catalase and peroxidases","volume":"11","author":"Chance","year":"1955","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2013.09.021_bib0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0009-2797(94)90099-X","article-title":"Reduction and binding of arsenate and dimethularsinate by glutathione: a magnetic resonance study","volume":"90","author":"Delnomdedieu","year":"1994","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2013.09.021_bib0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","article-title":"Mitochondria as the central control point of apoptosis","volume":"10","author":"Desagher","year":"2000","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.etap.2013.09.021_bib0060","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1046\/j.1432-1327.2000.01597.x","article-title":"Glutathione metabolism in brain metabolic interactions between astrocytes and neurons in the defense against reactive oxygen species","volume":"267","author":"Dringen","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.etap.2013.09.021_bib0065","first-page":"7369","article-title":"The role of glutathione S-transferase on anticancer drug resistance","volume":"22","author":"Dynyelle","year":"2003","journal-title":"Drug. Resist."},{"issue":"2","key":"10.1016\/j.etap.2013.09.021_bib0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","article-title":"Arsenic-induced oxidative stress and its reversibility","volume":"51","author":"Flora","year":"2011","journal-title":"Free Radic. Biol Med."},{"key":"10.1016\/j.etap.2013.09.021_bib0075","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1742-7843.2011.00836.x","article-title":"Monoisoamyl 2,3-dimercaptosuccinic Acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: a pharmacokinetic approach","volume":"110","author":"Flora","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jat.890","article-title":"Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II Changes in female rats","volume":"23","author":"Flora","year":"2003","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0085","series-title":"Pharmacological perspectives of some toxic chemicals and antidotes","first-page":"271","article-title":"Chronic arsenic poisoning: diagnosis and treatment","author":"Flora","year":"2004"},{"key":"10.1016\/j.etap.2013.09.021_bib0090","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.neuron.2008.09.002","article-title":"From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function","author":"Geer","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.etap.2013.09.021_bib0095","first-page":"436","article-title":"Chronic arsenic toxicity and human health","volume":"128","author":"Guha Mazumder","year":"2008","journal-title":"Ind. J. Med. Res."},{"key":"10.1016\/j.etap.2013.09.021_bib0100","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.etap.2005.05.005","article-title":"Therapeutic effects of Moringa oleifera on arsenic induced toxicity in rats","volume":"20","author":"Gupta","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2013.09.021_bib0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0968-0004(90)90206-Q","article-title":"The measurement and mechanism of lipid peroxidation in biological systems","volume":"15","author":"Gutteridge","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.etap.2013.09.021_bib0110","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-transferase the first step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2013.09.021_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1539\/joh.47.1","article-title":"Strategies for safe and effective treatment for chronic arsenic and lead poisoning","volume":"47","author":"Kalia","year":"2005","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.etap.2013.09.021_bib0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/BTER:110:1:43","article-title":"Combined administration of N-acetylcysteine and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy","volume":"110","author":"Kannan","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.etap.2013.09.021_bib0125","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1080\/10934520600873571","article-title":"Human health effects from chronic arsenic poisoning\u2014a review","volume":"41","author":"Kapaj","year":"2006","journal-title":"J. Environ. Sci. Health A"},{"key":"10.1016\/j.etap.2013.09.021_bib0135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/faat.1994.1075","article-title":"Zinc-induced arsenite tolerance in mice","volume":"23","author":"Kreppel","year":"1994","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0076-6879(79)55008-3","article-title":"Preparation of synaptic and nonsynaptic mitochondria from mammalian brain","volume":"55","author":"Lai","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2013.09.021_bib0145","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1289\/ehp.9611","article-title":"Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic","volume":"115","author":"Lantz","year":"2007","journal-title":"Environ Health Perspect."},{"key":"10.1016\/j.etap.2013.09.021_bib0150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/brain\/awg014","article-title":"Lead neurotoxicity in children: basic mechanisms and clinical correlates","volume":"126","author":"Lidsky","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.etap.2013.09.021_bib0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156720506778249515","article-title":"Oxidative stress: apoptosis in neuronal injury","volume":"3","author":"Loh","year":"2006","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.etap.2013.09.021_bib0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00204-007-0272-8","article-title":"Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid","volume":"82","author":"Manna","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(00)00306-1","article-title":"Effects of antioxidant enzymes in the molecular control of reactive oxygen species","volume":"153","author":"Mates","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2013.09.021_bib0170","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jat.871","article-title":"Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA","volume":"22","author":"Mehta","year":"2002","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0175","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2013.09.021_bib0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.2000.80.1.315","article-title":"Mitochondria and neuronal survival","volume":"80","author":"Nicholls","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.etap.2013.09.021_bib0185","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","article-title":"Caspases: killer proteases","volume":"22","author":"Nicholson","year":"1997","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/j.etap.2013.09.021_bib0190","first-page":"351","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Arch. Biochem."},{"key":"10.1016\/j.etap.2013.09.021_bib0195","first-page":"330","article-title":"Oxidative damage induced by metals without redox capacity in biological systems","volume":"47","author":"Oteiza","year":"1995","journal-title":"Ciencia Cult."},{"key":"10.1016\/j.etap.2013.09.021_bib0200","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jat.1149","article-title":"Morphological and functional alterations in human proximal tubular cell line induced by low level inorganic arsenic: evidence for targeting of mitochondria and initiated apoptosis","volume":"26","author":"Peraza","year":"2006","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.919117","article-title":"Cellular and molecular toxicity of lead in bone","volume":"91","author":"Pound","year":"1991","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.etap.2013.09.021_bib0210","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3923\/jpt.2006.270.277","article-title":"Influence of calcium and zinc on lead-induced alterations in ATPases in the developing mouse brain","volume":"1","author":"Prasanthi","year":"2006","journal-title":"J. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mrfmmm.2003.07.015","article-title":"Metal-induced apoptosis: mechanisms","volume":"533","author":"Pulido","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.etap.2013.09.021_bib0220","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium; bio chemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.etap.2013.09.021_bib0225","first-page":"729","article-title":"Lead perturbs calmodulin dependent cyclic AMP metabolism in rat central nervous system","volume":"33","author":"Sandhir","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.etap.2013.09.021_bib0230","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx00031a016","article-title":"Reaction of arsenic(III) and arsenic (V) species with glutathione","volume":"6","author":"Scott","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0235","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/B:MCBI.0000007262.26044.e8","article-title":"Oxidative mechanism of arsenic toxicity and carcinogenesis","volume":"255","author":"Shi","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2013.09.021_bib0240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jbt.20209","article-title":"Protective effect of arjunolic acid against arsenic induced oxidative stress in mouse brain","volume":"22","author":"Sinha","year":"2008","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0245","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00204-002-0350-x","article-title":"Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney","volume":"76","author":"Sivaprasad","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2013.09.021_bib0250","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0005-2744(69)90280-0","article-title":"Purification and properties of glutathione reductase of human erythrocytes","volume":"185","author":"Staal","year":"1969","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.etap.2013.09.021_bib0255","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0891-5849(94)00159-H","article-title":"Oxidative mechanisms in the toxicity of metal ions","volume":"18","author":"Stohs","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.etap.2013.09.021_bib0260","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.taap.2006.11.035","article-title":"Iron supplement prevents lead-induced disruption of the blood\u2013brain barrier during rat development","volume":"219","author":"Wang","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2013.09.021_bib0265","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12011-009-8455-1","article-title":"Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in offspring rats","volume":"134","author":"Xi","year":"2010","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668913002135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668913002135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T22:41:10Z","timestamp":1646779270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668913002135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S1382668913002135"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2013.09.021","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: Reversal effect of essential metals and a chelating agent","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2013.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}