{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:49:35Z","timestamp":1786988975816,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.etap.2014.03.002","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T18:09:12Z","timestamp":1396030152000},"page":"1202-1211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats"],"prefix":"10.1016","volume":"37","author":[{"given":"Temidayo O.","family":"Omobowale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola A.","family":"Oyagbemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinleye S.","family":"Akinrinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale B.","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwabusola T.","family":"Daramola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing S.","family":"Ogunpolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-0801","authenticated-orcid":false,"given":"James O.","family":"Olopade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2014.03.002_bib0010","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1056\/NEJMoa030535","article-title":"Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease","volume":"349","author":"Blankenberg","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.etap.2014.03.002_bib0015","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Buetler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.etap.2014.03.002_bib0020","series-title":"Lead Poisoning","first-page":"45","author":"Cantarow","year":"1944"},{"key":"10.1016\/j.etap.2014.03.002_bib0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.etap.2009.06.002","article-title":"Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes","volume":"28","author":"Chen","year":"2009","journal-title":"Environ. Toxicol. Pharmcol."},{"key":"10.1016\/j.etap.2014.03.002_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxlet.2011.03.017","article-title":"Divalent lead cations induce cyclooxygenase-2 gene expression by epidermal growth factor receptor\/nuclear factor-kappa B signaling in A431carcinoma cells","volume":"203","author":"Chou","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2014.03.002_bib0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.talanta.2012.11.043","article-title":"Lead biomonitoring in different organs of lead intoxicated rats employing GF AAS and different sample preparations","volume":"104","author":"de Sousa","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.etap.2014.03.002_bib0040","series-title":"Carlton's Histopathological Techniques","author":"Drury","year":"1976"},{"key":"10.1016\/j.etap.2014.03.002_bib0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0278-6915(00)00039-9","article-title":"Chemoprevention of 2 acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron \u2013 a Garcina kola seed extract","volume":"38","author":"Farombi","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2014.03.002_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00244-012-9786-z","article-title":"Pyruvate kinase activity and \u03b4-aminolevulinic acid dehydratase activity as biomarkers of toxicity in workers exposed to lead","volume":"63","author":"Feksa","year":"2012","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.etap.2014.03.002_bib0055","first-page":"130","article-title":"Glutathione-S-transferase activity: the enzymic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2014.03.002_bib0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0300-483X(02)00380-3","article-title":"Antioxidant nutrients and lead toxicity","volume":"180","author":"Hsu","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0065","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0300-483X(76)90056-1","article-title":"Effect of short-term administration of lead to pregnant rats","volume":"5","author":"Hubermont","year":"1976","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0075","series-title":"Bromobenzene-Induced Liver Necrosis; Protective Role of GSH & Evidence for 3, 4 Bromobenzene Oxide as the Hepatotoxic Metabolite","first-page":"108","author":"Jollow","year":"1994"},{"key":"10.1016\/j.etap.2014.03.002_bib0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tox.2012.07.002","article-title":"Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead","volume":"301","author":"Kasperczyk","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00128-013-1011-x","article-title":"Tissue distribution of metals in white-fronted geese and spot-billed ducks from Korea","volume":"91","author":"Kim","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.etap.2014.03.002_bib0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2013.01.008","article-title":"Protective potential of black grapes against lead induced oxidative stress in rats","volume":"35","author":"Lakshmi","year":"2013","journal-title":"Environ. Toxicol. Pharmcol."},{"key":"10.1016\/j.etap.2014.03.002_bib0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-4274(02)00404-6","article-title":"Effects of low doses of dietary lead on red blood cell production in male and female mice","volume":"137","author":"Iavicoli","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2014.03.002_bib0100","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.etap.2009.12.006","article-title":"Quercetin protects rat liver against lead-induced oxidative stress and apoptosis","volume":"29","author":"Liu","year":"2010","journal-title":"Environ. Toxicol. Pharmcol."},{"key":"10.1016\/j.etap.2014.03.002_bib0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1637\/8055-070907-Reg","article-title":"Inactivation of avian influenza virus using common detergents and chemicals","volume":"52","author":"Lombardi","year":"2008","journal-title":"Avian Dis."},{"key":"10.1016\/j.etap.2014.03.002_bib0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2014.03.002_bib0115","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anoin in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"217","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2014.03.002_bib0120","doi-asserted-by":"crossref","first-page":"917","DOI":"10.4067\/S0034-98872013000700012","article-title":"Acute hepatitis due to infectious mononucleosis in a 21-year-old-man","volume":"141","author":"Modesto Dos Santos","year":"2013","journal-title":"Rev. M\u00e9d. Chil."},{"key":"10.1016\/j.etap.2014.03.002_bib0125","doi-asserted-by":"crossref","first-page":"320704","DOI":"10.1155\/2013\/320704","article-title":"Voluntary exercise prevents lead-induced elevation of oxidative stress and inflammation markers in male rat blood","author":"Mohammadi","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.etap.2014.03.002_bib0130","first-page":"518","article-title":"Lead hepatotoxicity and potential health effects","volume":"126","author":"Mudipalli","year":"2007","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.etap.2014.03.002_bib0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0300-483X(02)00223-8","article-title":"Lead induced oxidative damage and its response to combined administration of lipoic acid and succimers in rats","volume":"177","author":"Pande","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/ijerph2006030041","article-title":"Effect of lead (Pb) exposure on the activity of superoxide dismutase and catalase in battery manufacturing workers (BMW) of Western Maharashtra (India) with reference to heme biosynthesis","volume":"3","author":"Patil","year":"2006","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.etap.2014.03.002_bib0145","first-page":"457327","article-title":"Oxidative stress in lead and cadmium toxicity and its amelioration","author":"Patra","year":"2011","journal-title":"Vet. Med. Int."},{"key":"10.1016\/j.etap.2014.03.002_bib0150","first-page":"114","article-title":"Lead toxicity part II \u2013 the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity","volume":"11","author":"Patrick","year":"2006","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.etap.2014.03.002_bib0155","series-title":"Proceedings XIV International Congress on Occupational Health, vol. III","first-page":"1068","author":"Pecora","year":"1963"},{"key":"10.1016\/j.etap.2014.03.002_bib0160","series-title":"Public Health Service Policy on Humane Care and the Use of Laboratory Animals","first-page":"99","author":"PHS (PUBLIC HEALTH SERVICE)","year":"1996"},{"key":"10.1016\/j.etap.2014.03.002_bib0165","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1007\/s11356-013-1475-6","article-title":"Lead-induced oxidative damage in steriled seedlings of Nymphoides peltatum","volume":"20","author":"Qiao","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.etap.2014.03.002_bib0170","first-page":"182","article-title":"Optimised standard colorimetric methods","volume":"10","author":"Rec. Gscc (DGKC)","year":"1972","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.etap.2014.03.002_bib0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"Colorimetric method for the determination of serum transaminase activity","volume":"28","author":"Reitmann","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.etap.2014.03.002_bib0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2005.05.026","article-title":"Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats","volume":"214","author":"Saxena","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2004.07.006","article-title":"Amelioration of lead toxicity on rat liver with vitamin C and silymarin supplements","volume":"206","author":"Shalana","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.002_bib0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013006923","article-title":"Reversal of lead-induced toxicity due to the effect of antioxidants","volume":"32","author":"Sharma","year":"2013","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.etap.2014.03.002_bib0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Shinha","year":"1972","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2014.03.002_bib0200","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0076-6879(74)31019-1","article-title":"Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes","volume":"31","author":"Steck","year":"1974","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2014.03.002_bib0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12640-010-9167-1","article-title":"The mechanism of vanadium-mediated developmental hypomyelination is related to destruction of oligodendrocyte progenitors through a relationship with ferritin and iron","volume":"19","author":"Todorich","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.etap.2014.03.002_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2014.03.002_bib0215","first-page":"563","article-title":"Effect of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in liver","volume":"51","author":"Wang","year":"2007","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.etap.2014.03.002_bib0220","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12011-011-9268-6","article-title":"Protective effect of naringenin against lead-induced oxidative stress in rats","volume":"146","author":"Wang","year":"2012","journal-title":"Biol. Trace Element Res."},{"key":"10.1016\/j.etap.2014.03.002_bib0225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4103\/0253-7613.115015","article-title":"Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats","volume":"45","author":"Wang","year":"2013","journal-title":"Indian J. Pharmcol."},{"key":"10.1016\/j.etap.2014.03.002_bib0230","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydrogen peroxides","volume":"233","author":"Woff","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.etap.2014.03.002_bib0235","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cardiores.2005.09.019","article-title":"Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells","volume":"69","author":"Wu","year":"2006","journal-title":"Cardiovasc. Res."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266891400057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266891400057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T23:10:54Z","timestamp":1761433854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138266891400057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S138266891400057X"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.002","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}