{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T22:18:04Z","timestamp":1768861084749,"version":"3.49.0"},"update-to":[{"DOI":"10.1016\/j.etap.2014.03.006","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000}}],"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007102","name":"Zagazig University","doi-asserted-by":"publisher","award":["5K2\/M4"],"award-info":[{"award-number":["5K2\/M4"]}],"id":[{"id":"10.13039\/501100007102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.etap.2014.03.006","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T23:16:11Z","timestamp":1395184571000},"page":"907-915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["RETRACTED: Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats"],"prefix":"10.1016","volume":"37","author":[{"given":"Dalia I.","family":"Hamdan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona F.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assem M.","family":"El-Shazly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2014.03.006_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","article-title":"Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation","volume":"208","author":"Ahmad","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2014.03.006_bib0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1179\/1351000212Y.0000000019","article-title":"Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats","volume":"17","author":"Anandan","year":"2012","journal-title":"Redox. Rep."},{"key":"10.1016\/j.etap.2014.03.006_bib0015","series-title":"Flavonoids: Chemistry, Biochemistry and Applications","author":"Andersen","year":"2006"},{"key":"10.1016\/j.etap.2014.03.006_bib0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11010-008-9930-2","article-title":"Influence of l-rhamnosyl-d-glucosyl derivatives on properties and biological interaction of flavonoids","volume":"321","author":"Bellocco","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2014.03.006_bib0025","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1021\/jf970373s","article-title":"Uses and properties of citrus flavonoids","volume":"45","author":"Benavente-Garcia","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.etap.2014.03.006_bib0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0021-9673(99)00708-6","article-title":"Liquid chromatographic\u2013mass spectrometric determination of phenolic compounds using a capillary-scale particle beam interface","volume":"855","author":"Cappiello","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.etap.2014.03.006_bib0035","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/(SICI)1097-0231(19991215)13:23<2399::AID-RCM805>3.0.CO;2-N","article-title":"Validation of liquid chromatography ionspray mass spectrometry method for the analysis of flavanones, flavones and flavonols","volume":"13","author":"Careri","year":"1999","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.etap.2014.03.006_bib0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1590\/S0102-86502006000300009","article-title":"Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats","volume":"21","author":"Cavallini","year":"2006","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.etap.2014.03.006_bib0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3892\/or.2010.1105","article-title":"Anti-pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals","volume":"25","author":"Choi","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.etap.2014.03.006_bib0050","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1051\/analusis:2000280888","article-title":"Tandam mass spectral strategies for the structure characterization of flavonoid glycosides","volume":"28","author":"Cuyckens","year":"2000","journal-title":"Analysis"},{"key":"10.1016\/j.etap.2014.03.006_bib0055","first-page":"481","article-title":"l-Carnitine inhibits ethanol-induced gastric mucosa injury in rats","volume":"57","author":"Dokmeci","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.etap.2014.03.006_bib0060","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jssc.200500053","article-title":"Determination of flavonoids in citrus juices by micro-HPLC-ESI\/MS","volume":"28","author":"Dugo","year":"2005","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.etap.2014.03.006_bib0065","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/j.2042-7158.2012.01512.x","article-title":"Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart","volume":"64","author":"Elavarasan","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.006_bib0070","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.etap.2014.03.006_bib0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.2042-7158.1994.tb03753.x","article-title":"Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice","volume":"46","author":"Emim","year":"1994","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.006_bib0080","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0014-827X(01)01111-9","article-title":"Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat","volume":"56","author":"Guardia","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.etap.2014.03.006_bib0085","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.foodchem.2010.12.129","article-title":"Chemical composition and biological activity of Citrus jambhiri Lush","volume":"127","author":"Hamdan","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.etap.2014.03.006_bib0090","series-title":"The Handbook of Natural Flavonoids","author":"Harborne","year":"1999"},{"key":"10.1016\/j.etap.2014.03.006_bib0095","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.2042-7158.2011.01405.x","article-title":"Peonage-San extract (KMP6): a new anti-allergic effect","volume":"64","author":"Han","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.006_bib0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5560\/ZNC.2012.67c0144","article-title":"Chemical constituents and biological activities of Senecio aegyptius var. discoideus Boiss","volume":"67c","author":"Hassan","year":"2012","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.etap.2014.03.006_bib0105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00011-010-0295-0","article-title":"Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation","volume":"6","author":"Jain","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.etap.2014.03.006_bib0110","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ejphar.2010.09.017","article-title":"Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9","volume":"649","author":"Kamaraj","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.006_bib0115","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/ptr.2840","article-title":"Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2014.03.006_bib0120","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/ptr.3209","article-title":"7,3\u2032-Dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation","volume":"24","author":"Li","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2014.03.006_bib0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08923973.2012.723010","article-title":"7,3\u2032-Dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis","volume":"35","author":"Li","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.etap.2014.03.006_bib0130","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jdiacomp.2012.06.001","article-title":"Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed\/streptozotocin-induced type 2 diabetic rats","volume":"2","author":"Mahmoud","year":"2012","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.etap.2014.03.006_bib0135","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.foodchem.2009.03.023","article-title":"Identification of natural epimeric flavanone glycosides by NMR spectroscopy","volume":"116","author":"Maltese","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.etap.2014.03.006_bib0140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.pbb.2010.11.010","article-title":"Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats","volume":"97","author":"Mart\u00ednez","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.etap.2014.03.006_bib0145","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1073\/pnas.95.7.3408","article-title":"Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme","volume":"95","author":"Maskos","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.etap.2014.03.006_bib0150","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ejphar.2010.10.053","article-title":"Inactivation of nuclear factor-\u03baB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells","volume":"650","author":"Nazari","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.006_bib0155","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jphotobiol.2011.02.020","article-title":"Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice","volume":"103","author":"Petrova","year":"2011","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.etap.2014.03.006_bib0160","first-page":"390","article-title":"An overview of Citrus aurantium used in treatment of various diseases","volume":"5","author":"Surayawanshi","year":"2011","journal-title":"Afr. J. Plant Sci."},{"key":"10.1016\/j.etap.2014.03.006_bib0165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cca.2009.12.026","article-title":"Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage","volume":"411","author":"Takeuchi","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.etap.2014.03.006_bib0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0928-4257(01)00005-5","article-title":"Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs","volume":"95","author":"Tanaka","year":"2001","journal-title":"J. Physiol. Paris"},{"issue":"Suppl. 2","key":"10.1016\/j.etap.2014.03.006_bib0175","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2036.16.s2.22.x","article-title":"Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury","volume":"16","author":"Tanaka","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2014.03.006_bib0180","first-page":"657","article-title":"Gastric antisecretory, anti-ulcer and cytoprotective properties of 9-hydroxy-19,20-bis-nor-prostanoic acid in experimental animals","volume":"32","author":"Valcavi","year":"1982","journal-title":"Arzneim Forsch.\/Drug Res."},{"key":"10.1016\/j.etap.2014.03.006_bib0185","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1210\/en.2002-220410","article-title":"Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha-1beta, and IL-6 mRNA levels in Leydig cell progenitors","volume":"143","author":"Walch","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2014.03.006_bib0190","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","article-title":"NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2014.03.006_bib0195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1254\/jphs.11097FP","article-title":"Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats","volume":"117","author":"Wang","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.etap.2014.03.006_bib0200","series-title":"Biochemical Toxicology: A Practical Approach","article-title":"Evaluation of lipid peroxidation in lipids and biological membranes","author":"Wills","year":"1987"}],"updated-by":[{"DOI":"10.1016\/j.etap.2014.03.006","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000}},{"DOI":"10.1016\/j.etap.2025.104851","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000}},{"DOI":"10.1016\/j.etap.2025.104851","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000}},{"DOI":"10.1016\/j.etap.2025.104851","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"record-id":"68528"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668914000611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668914000611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:39:29Z","timestamp":1766122769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668914000611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1382668914000611"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.006","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}