{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:01:15Z","timestamp":1792202475040,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004858","name":"Sichuan University of Science and Engineering","doi-asserted-by":"publisher","award":["2013RC14"],"award-info":[{"award-number":["2013RC14"]}],"id":[{"id":"10.13039\/501100004858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.etap.2014.03.011","type":"journal-article","created":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T08:18:50Z","timestamp":1395562730000},"page":"975-983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":125,"title":["Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"37","author":[{"given":"Jie-Qiong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2014.03.011_bib0005","doi-asserted-by":"crossref","first-page":"e31318","DOI":"10.1371\/journal.pone.0031318","article-title":"Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-kB, AP-1 and NF-AT","volume":"7","author":"Checker","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.etap.2014.03.011_bib0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1743-7075-10-20","article-title":"Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats","volume":"10","author":"Ebaid","year":"2013","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.etap.2014.03.011_bib0015","first-page":"933","article-title":"Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats","volume":"10","author":"Gayathri","year":"2009","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.etap.2014.03.011_bib0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.04.012","article-title":"New therapeutic aspect for carvedilol: anti fibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage","volume":"261","author":"Hamdy","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0025","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00204-008-0394-7","article-title":"Effect of \u03b1-tocopherol on carbon tetrachloride intoxication in the rat liver","volume":"83","author":"Iida","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2014.03.011_bib0030","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.bcp.2005.08.008","article-title":"Ursolic acid promotes the release of macrophag emigration inhibitory factor via ERK2 activation in resting mouse macrophages","volume":"70","author":"Ikeda","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0035","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.4049\/jimmunol.178.8.4854","article-title":"Aggregated ursolic acid, a natural triterpenoid, induces IL-1\u03b2 release from murine peritoneal macrophages: role of CD36","volume":"178","author":"Ikeda","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2014.03.011_bib0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2011.01.017","article-title":"Ferulic acid protects against carbon tetrachloride-induced liver injury in mice","volume":"282","author":"Kim","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.011_bib0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-483X(00)00437-6","article-title":"Role of macrophages and inflammatory mediators in chemically induced toxicity","volume":"160","author":"Laskin","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2014.03.011_bib0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.fct.2012.10.059","article-title":"Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function","volume":"52","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2014.03.011_bib0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/faat.1994.1005","article-title":"The effects of 10 triterpenoid compounds on experimental liver injury in mice","volume":"22","author":"Liu","year":"1994","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.etap.2014.03.011_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.taap.2011.11.015","article-title":"Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K\/Akt\/eNOS pathway","volume":"258","author":"Liu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0065","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/jf304562b","article-title":"Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway","volume":"61","author":"Liu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.etap.2014.03.011_bib0070","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/10715762.2012.760198","article-title":"Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1\/JNK and PI3K\/Akt pathway","volume":"47","author":"Liu","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.etap.2014.03.011_bib0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejps.2011.11.002","article-title":"Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP","volume":"45","author":"Lv","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.etap.2014.03.011_bib0080","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.etap.2011.02.007","article-title":"Ganoderma applanatum terpenes protect mouse liver against benzo(\u03b1)pyren-induced oxidative stress and inflammation","volume":"31","author":"Ma","year":"2011","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1078\/0940-2993-00185","article-title":"Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes","volume":"53","author":"Martin-Aragon","year":"2001","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.etap.2014.03.011_bib0090","first-page":"743","article-title":"Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases","volume":"121","author":"Martinez","year":"2003","journal-title":"Med. Clin."},{"key":"10.1016\/j.etap.2014.03.011_bib0095","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Onkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2014.03.011_bib0100","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.lfs.2005.05.060","article-title":"Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats","volume":"78","author":"Saravanan","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.etap.2014.03.011_bib0105","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.bcp.2013.03.006","article-title":"Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies","volume":"85","author":"Shanmugam","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0110","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.taap.2009.11.005","article-title":"Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the in flammatory response","volume":"242","author":"Shim","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0115","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12272-013-0050-5","article-title":"Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats","volume":"36","author":"Shin","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.etap.2014.03.011_bib0120","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.neuro.2007.03.002","article-title":"Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal","volume":"28","author":"Shinomol","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etap.2014.03.011_bib0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2008.05.006","article-title":"Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats","volume":"26","author":"Singh","year":"2008","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"Tacke","year":"2009","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.etap.2014.03.011_bib0135","doi-asserted-by":"crossref","first-page":"e86557","DOI":"10.1371\/journal.pone.0086557","article-title":"Aqueous extract of Gracilaria tenuistipitata suppresses LPS-Induced NF-kB and MAPK Activation in RAW 264.7 and rat peritoneal macrophages and exerts hepatoprotective effects on carbon tetrachloride treated rat","volume":"9","author":"Tseng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2014.03.011_bib0140","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.fct.2012.05.050","article-title":"Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1. Toll-like receptor 4 and 2 expression","volume":"50","author":"Tu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2014.03.011_bib0145","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.taap.2012.11.007","article-title":"Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice","volume":"266","author":"Wang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2014.03.011_bib0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.etap.2014.03.011_bib0155","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1021\/jf1045624","article-title":"Suppression of hepatitis B virus X protein-mediated tumorigenic effects by ursolic acid","volume":"59","author":"Wu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.etap.2014.03.011_bib0160","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s12272-012-0513-0","article-title":"Attenuation of aortic injury by ursolic acid through RAGE-Nox-NF\u03baB pathway in streptozocin-induced diabetic rats","volume":"35","author":"Xiang","year":"2012","journal-title":"Arch. Pharm. Res."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668914000660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668914000660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T23:08:57Z","timestamp":1761433737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668914000660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1382668914000660"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.011","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2014.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}