{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:53:17Z","timestamp":1789494797972,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.etap.2014.06.003","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T18:43:04Z","timestamp":1402944184000},"page":"239-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells"],"prefix":"10.1016","volume":"38","author":[{"given":"Hye Hyeon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Kwon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wun-Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Kee","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hyun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2014.06.003_bib0005","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1021\/jf990862n","article-title":"Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.","volume":"48","author":"Ahn","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.etap.2014.06.003_bib0010","first-page":"86","article-title":"Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells","volume":"49","author":"Baik","year":"2012","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.etap.2014.06.003_bib0015","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1038\/onc.2009.47","article-title":"Bid: a Bax-like BH3 protein","volume":"27","author":"Billen","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.etap.2014.06.003_bib0020","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ceb.2009.09.004","article-title":"Mitochondrial cell death effectors","volume":"21","author":"Brenner","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.etap.2014.06.003_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3858\/emm.2012.44.2.033","article-title":"Autophagy and cancer","volume":"44","author":"Choi","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.etap.2014.06.003_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.taap.2011.08.030","article-title":"Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor","volume":"257","author":"Choi","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/166949a0","article-title":"Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link","volume":"166","author":"Cunningham","year":"1950","journal-title":"Nature"},{"key":"10.1016\/j.etap.2014.06.003_bib0040","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/sj.cdd.4401950","article-title":"Mechanisms of cytochrome c release from mitochondria","volume":"13","author":"Garrido","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.etap.2014.06.003_bib0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1476-4598-8-39","article-title":"Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation","volume":"8","author":"Gill","year":"2009","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.etap.2014.06.003_bib0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1008654316572","article-title":"Apoptosis: molecular mechanisms and implications for cancer chemotherapy","volume":"19","author":"Guchelaar","year":"1997","journal-title":"Pharm. World Sci."},{"key":"10.1016\/j.etap.2014.06.003_bib0055","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1631\/jzus.B1000081","article-title":"Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules","volume":"11","author":"He","year":"2010","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.etap.2014.06.003_bib0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000322395","article-title":"Cordycepin (3\u2032-deoxyadenosine), an inhibitor of mRNA polyadenylation, suppresses proliferation and activates apoptosis in human epithelial endometriotic cells in vitro","volume":"72","author":"Imesch","year":"2011","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.etap.2014.06.003_bib0065","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0070","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.tiv.2011.02.001","article-title":"Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells","volume":"25","author":"Jeong","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.etap.2014.06.003_bib0075","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.4014\/jmb.1203.03039","article-title":"Effect of cordycepin purified from Cordyceps militaris on Th1 and Th2 cytokines in mouse splenocytes","volume":"22","author":"Jeong","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.etap.2014.06.003_bib0080","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbamcr.2011.01.026","article-title":"Caspase-8 and bid: caught in the act between death receptors and mitochondria","volume":"1813","author":"Kantari","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.etap.2014.06.003_bib0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejphar.2006.06.047","article-title":"Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264 7 macrophage cells","volume":"545","author":"Kim","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0090","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.4161\/auto.26308","article-title":"BIX-01294 induces autophagy-associated cell death via EHMT2\/G9a dysfunction and intracellular reactive oxygen species production","volume":"9","author":"Kim","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.etap.2014.06.003_bib0095","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1261\/rna.032391.112","article-title":"Inhibition of polyadenylation reduces inflammatory gene induction","volume":"18","author":"Kondrashov","year":"2012","journal-title":"RNA"},{"key":"10.1016\/j.etap.2014.06.003_bib0100","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/ptr.3132","article-title":"Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells","volume":"24","author":"Lee","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2014.06.003_bib0105","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3892\/ijo.2013.1762","article-title":"Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species-mediated mitochondrial death pathway","volume":"42","author":"Lee","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.etap.2014.06.003_bib0110","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3892\/or.2013.2589","article-title":"Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway","volume":"30","author":"Lee","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.etap.2014.06.003_bib0115","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s10637-012-9859-x","article-title":"The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells","volume":"30","author":"Lee","year":"2012","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.etap.2014.06.003_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.etap.2014.06.003_bib0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","article-title":"Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics","volume":"21","author":"Martinou","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.etap.2014.06.003_bib0130","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1247\/csf.27.421","article-title":"Autophagosome formation in mammalian cells","volume":"27","author":"Mizushima","year":"2002","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.etap.2014.06.003_bib0135","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.bbamcr.2013.06.001","article-title":"Crosstalk between apoptosis, necrosis and autophagy","volume":"1833","author":"Nikoletopoulou","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.etap.2014.06.003_bib0140","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1073\/pnas.67.4.1878","article-title":"Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin","volume":"67","author":"Penman","year":"1970","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.etap.2014.06.003_bib0145","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.exger.2012.09.003","article-title":"Cordycepin (3\u2032-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats","volume":"47","author":"Ramesh","year":"2012","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.etap.2014.06.003_bib0150","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.intimp.2012.10.008","article-title":"Cordycepin suppresses TNF-\u03b1-induced NF-\u03baB activation by reducing p65 transcriptional activity, inhibiting I\u03baB\u03b1 phosphorylation, and blocking IKK\u03b3 ubiquitination","volume":"14","author":"Ren","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0155","first-page":"758","article-title":"Incorporation of 3\u2032-deoxyadenosine-5\u2032-triphosphate into RNA by RNA polymerase from Micrococcus lysodeikticus","volume":"17","author":"Shigeura","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2014.06.003_bib0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4110\/in.2009.9.3.98","article-title":"Cordycepin suppresses expression of diabetes regulating genes by inhibition of lipopolysaccharide-induced inflammation in macrophages","volume":"9","author":"Shin","year":"2009","journal-title":"Immune Netw."},{"key":"10.1016\/j.etap.2014.06.003_bib0165","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/AAC.42.6.1424","article-title":"Antifungal activity of 3\u2032-deoxyadenosine (cordycepin)","volume":"42","author":"Sugar","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.etap.2014.06.003_bib0170","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/S0021-9258(18)93437-X","article-title":"The incorporation of sangivamycin 5\u2032-triphosphate into polyribonucleotide by ribonucleic acid polymerase from Micrococcus lysodeikticus","volume":"243","author":"Suhadolnik","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2014.06.003_bib0175","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5483\/BMBRep.2012.45.4.242","article-title":"Resveratrol and piperine enhance radiosensitivity of tumor cells","volume":"45","author":"Tak","year":"2012","journal-title":"BMB Rep."},{"key":"10.1016\/j.etap.2014.06.003_bib0180","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1089\/ars.2010.3482","article-title":"Autophagosome formation and molecular mechanism of autophagy","volume":"14","author":"Tanida","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.etap.2014.06.003_bib0185","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.etap.2014.06.003_bib0190","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(95)90541-3","article-title":"Yama\/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase","volume":"81","author":"Tewari","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.etap.2014.06.003_bib0195","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00280-007-0467-y","article-title":"The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner","volume":"61","author":"Thomadaki","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0200","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/BC.2005.056","article-title":"Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction","volume":"386","author":"Thomadaki","year":"2005","journal-title":"Biol. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.etap.2014.06.003_bib0205","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1464-410X.2005.05944.x","article-title":"Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins","volume":"96","author":"Watson","year":"2005","journal-title":"BJU Int."},{"key":"10.1016\/j.etap.2014.06.003_bib0210","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00280-006-0354-y","article-title":"The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line","volume":"60","author":"Wu","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.etap.2014.06.003_bib0215","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3109\/10715762.2011.647688","article-title":"Cordycepin inhibits albumin-induced epithelial\u2013mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production","volume":"46","author":"Xiao","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.etap.2014.06.003_bib0220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.etap.2014.06.003_bib0225","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1142\/S0192415X08006387","article-title":"Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis","volume":"36","author":"Zhou","year":"2008","journal-title":"Am. J. Chin. Med."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266891400146X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266891400146X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:16:34Z","timestamp":1649420194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138266891400146X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S138266891400146X"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2014.06.003","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2014.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}