{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:42:54Z","timestamp":1791772974032,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.etap.2015.04.010","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T06:19:20Z","timestamp":1429510760000},"page":"1161-1169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Assessment of benzene induced oxidative impairment in rat isolated pancreatic islets and effect on insulin secretion"],"prefix":"10.1016","volume":"39","author":[{"given":"Haji","family":"Bahadar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Maqbool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mostafalou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Baeeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahban","family":"Rahimifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Navaei-Nigjeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abdollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2015.04.010_bib0005","first-page":"RA141","article-title":"Pesticides and oxidative stress: a review","volume":"10","author":"Abdollahi","year":"2004","journal-title":"Med. Sci. Monitor"},{"key":"10.1016\/j.etap.2015.04.010_bib0010","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/EJE-11-0053","article-title":"Oxidative DNA damage and obesity in type 2 diabetes mellitus","volume":"164","author":"Al-aubaidy","year":"2011","journal-title":"Euro. J. Endocrinol."},{"key":"10.1016\/j.etap.2015.04.010_bib0015","first-page":"141","article-title":"The protective effect of garlic extract against acetaminophen-induced loss of mitochondrial membrane potential in freshly isolated rat hepatocytes","volume":"5","author":"Anoush","year":"2009","journal-title":"Iranian J. Pharm. Sci."},{"key":"10.1016\/j.etap.2015.04.010_bib0020","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.freeradbiomed.2009.08.014","article-title":"Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK","volume":"47","author":"Archuleta","year":"2009","journal-title":"Free Radical. Biol. Med."},{"key":"10.1016\/j.etap.2015.04.010_bib0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2014.02.012","article-title":"Current understandings and perspectives on non-cancer health effects of benzene: A global concern","volume":"276","author":"Bahadar","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2015.04.010_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40200-014-0117-y","article-title":"Growing burden of diabetes in Pakistan and the possible role of arsenic and pesticides","volume":"13","author":"Bahadar","year":"2014","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.etap.2015.04.010_bib0035","doi-asserted-by":"crossref","first-page":"e54374","DOI":"10.1371\/journal.pone.0054374","article-title":"Cadmium induces apoptosis in pancreatic beta-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated C-Jun N-terminal kinase activation","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2015.04.010_bib0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.taap.2009.11.024","article-title":"Inorganic mercury causes pancreatic \u03b2-cell death via the oxidative stress-induced apoptotic and necrotic pathways","volume":"243","author":"Chen","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2015.04.010_bib0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(96)90013-6","article-title":"Oxidative damage to DNA in diabetes mellitus","volume":"347","author":"Dandona","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.etap.2015.04.010_bib0050","doi-asserted-by":"crossref","first-page":"E615","DOI":"10.1152\/ajpendo.00578.2007","article-title":"Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase 3","volume":"294","author":"Dokken","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.etap.2015.04.010_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.52.1.1","article-title":"Are oxidative stress activated signaling pathways mediators of insulin resistance and \u03b2-cell dysfunction?","volume":"52","author":"Evans","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.etap.2015.04.010_bib0060","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1177\/15353702-0322807-09","article-title":"Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells","volume":"228","author":"Gardner","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.etap.2015.04.010_bib0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pestbp.2006.08.007","article-title":"Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative\/nitrosative stress in rat Langerhans islets cells: molecular evidence for involvement of non-cholinergic mechanisms","volume":"87","author":"Ghafour-Rashidi","year":"2007","journal-title":"Pesticide Biochem. Physiol."},{"key":"10.1016\/j.etap.2015.04.010_bib0070","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1289\/ehp.1307082","article-title":"Insulin resistance and environmental pollutants: experimental evidence and future perspectives","volume":"121","author":"Hectors","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2015.04.010_bib0075","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00125-011-2109-5","article-title":"Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function","volume":"54","author":"Hectors","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.etap.2015.04.010_bib0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxlet.2005.06.018","article-title":"Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite","volume":"160","author":"Izquierdo-Vega","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2015.04.010_bib0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tox.2006.11.072","article-title":"Altered glucose homeostasis and oxidative impairment in pancreas of rats subjected to dimethoate intoxication","volume":"231","author":"Kamath","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2015.04.010_bib0090","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.atmosenv.2006.10.052","article-title":"Contribution to ambient benzene concentrations in the vicinity of petrol stations: estimation of the associated health risk","volume":"41","author":"Karakitsios","year":"2007","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.etap.2015.04.010_bib0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxlet.2010.11.019","article-title":"Arsenic induces pancreatic \u03b2-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways","volume":"201","author":"Lu","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2015.04.010_bib0100","doi-asserted-by":"crossref","first-page":"21938","DOI":"10.1074\/jbc.C100109200","article-title":"Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade","volume":"276","author":"Mahadev","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2015.04.010_bib0105","first-page":"251","article-title":"Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats","volume":"140","author":"Milani","year":"2005","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2015.04.010_bib0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MPA.0b013e318181da4e","article-title":"Pancreatic islets are very poor in rectifying oxidative DNA damage","volume":"38","author":"Modak","year":"2009","journal-title":"Pancreas"},{"key":"10.1016\/j.etap.2015.04.010_bib0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","article-title":"Pesticides and human chronic diseases: evidences, mechanisms, and perspectives","volume":"268","author":"Mostafalou","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2015.04.010_bib0120","first-page":"101","article-title":"Protective effects of crocin against streptozotocin-induced oxidative damage in rat striatum","volume":"52","author":"Naghizadeh","year":"2014","journal-title":"Acta Medica Iranica"},{"key":"10.1016\/j.etap.2015.04.010_bib0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pestbp.2013.04.003","article-title":"On the biochemical and molecular mechanisms by which malathion induces dysfunction in pancreatic islets in vivo and in vitro","volume":"106","author":"Nili-ahmadabadi","year":"2013","journal-title":"Pesticide Biochem. Physiol."},{"key":"10.1016\/j.etap.2015.04.010_bib0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/15376520500191623","article-title":"Stimulatory effects of malathion on the key enzymes activities of insulin secretion in langerhans islets, glutamate dehydrogenase and glucokinase","volume":"16","author":"Panahi","year":"2006","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.etap.2015.04.010_bib0135","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/db06-1601","article-title":"Reactive oxygen species as a signal in glucose-stimulated insulin secretion","volume":"56","author":"Pi","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.etap.2015.04.010_bib0140","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3109\/15376516.2012.673093","article-title":"Improvement of isolated rat pancreatic islets function by combination of cerium oxide nanoparticles\/sodium selenite through reduction of oxidative stress","volume":"22","author":"Pourkhalili","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.etap.2015.04.010_bib0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mrfmmm.2005.06.012","article-title":"Oxidative stress-induced DNA damage by particulate air pollution","volume":"592","author":"Risom","year":"2005","journal-title":"Mutat. Res.\/Fund. Mol. Mech. Mutagen"},{"key":"10.1016\/j.etap.2015.04.010_bib0150","first-page":"201","article-title":"Oxidative mechanisms in the toxicity of chromium and cadmium ions","volume":"19","author":"Stohs","year":"1999","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.etap.2015.04.010_bib0155","first-page":"2","article-title":"Preparation of genomic DNA from mammalian tissue","volume":"2","author":"Strauss","year":"2001","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.etap.2015.04.010_bib0160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2011.10.441","article-title":"Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?","volume":"52","author":"Styskal","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.etap.2015.04.010_bib0165","first-page":"169","article-title":"Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury in the rat?","volume":"1362","author":"Sundari","year":"1997","journal-title":"Biophys. Acta"},{"key":"10.1016\/j.etap.2015.04.010_bib0170","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0041-008X(90)90037-U","article-title":"Pharmacokinetics of benzene","volume":"102","author":"Travis","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2015.04.010_bib0175","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/ajim.20901","article-title":"Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers","volume":"53","author":"Uzma","year":"2010","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.etap.2015.04.010_bib0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15428110208984708","article-title":"Benzene in gasoline and crude oil: occupational and environmental implications","volume":"63","author":"Verma","year":"2002","journal-title":"AIHA J."},{"key":"10.1016\/j.etap.2015.04.010_bib0185","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.biopha.2007.07.006","article-title":"Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice","volume":"63","author":"Zhang","year":"2009","journal-title":"Biomed. Pharmacother"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915001039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915001039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T20:01:56Z","timestamp":1566590516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668915001039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1382668915001039"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2015.04.010","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of benzene induced oxidative impairment in rat isolated pancreatic islets and effect on insulin secretion","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2015.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}