{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:23:45Z","timestamp":1762521825957,"version":"3.41.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.etap.2015.09.006","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T03:20:02Z","timestamp":1444965602000},"page":"901-906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation"],"prefix":"10.1016","volume":"40","author":[{"given":"Mohamed T.","family":"Khayyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania M.","family":"El-Hazek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona A.","family":"El-Ghazaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2015.09.006_bib0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jep.2005.05.004","article-title":"Chemical diversity of propolis and the problem of standardization","volume":"100","author":"Bankova","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etap.2015.09.006_bib0010","first-page":"32","article-title":"Effect of propolis against radiation-induced oral mucositis in rats","volume":"21","author":"Benderli","year":"2011","journal-title":"Kulak Burun Bogaz Ihtis Derg."},{"key":"10.1016\/j.etap.2015.09.006_bib0015","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.phymed.2008.02.010","article-title":"Radioprotective effect of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay","volume":"15","author":"Benkovic","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.etap.2015.09.006_bib0020","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"65","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.etap.2015.09.006_bib0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.bmt.1704563","article-title":"Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy","volume":"34","author":"Blijlevens","year":"2004","journal-title":"Bone Marrow Transpl."},{"key":"10.1016\/j.etap.2015.09.006_bib0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yexmp.2011.11.007","article-title":"Radiation-induced damage in different segments of the rat intestine after external beam irradiation of the liver","volume":"92","author":"Cameron","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.etap.2015.09.006_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4161\/cbt.5.1.2235","article-title":"Use of the 13C-sucrose breath test to assess chemotherapy-induced small intestinal mucositis in the rat","volume":"5","author":"Clarke","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.etap.2015.09.006_bib0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ghir.2004.12.002","article-title":"Pre-treatment with insulin-like growth factor-I partially ameliorate 5-fluorouracil-induced intestinal mucositis in rats","volume":"15","author":"Cool","year":"2005","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.etap.2015.09.006_bib0045","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0016-5085(03)00170-7","article-title":"Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease","volume":"124","author":"Crenn","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2015.09.006_bib0050","first-page":"53","article-title":"Effects of propolis and CAPE on proliferation and apoptosis of McCoy-Plovdiv cell line","volume":"50","author":"Draganova-Filipova","year":"2008","journal-title":"Folia Med. (Plovdiv)"},{"key":"10.1016\/j.etap.2015.09.006_bib0055","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood.V83.1.33.33","article-title":"A bone marrow stromal-derived growth factor, interluekin-11, stimulates recovery of small intestinal mucosal cells after cytoblative therapy","volume":"83","author":"Du","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.etap.2015.09.006_bib0060","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0016-5085(88)90512-4","article-title":"Prospects for management of gastrointestinal injury associated with the acute radiation syndrome","volume":"95","author":"Dubois","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2015.09.006_bib0065","first-page":"229","article-title":"The use of aqueous propolis extract against radiation-induced damage","volume":"21","author":"El-Ghazaly","year":"1995","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.etap.2015.09.006_bib0070","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3109\/09553002.2011.602378","article-title":"Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure","volume":"87","author":"El-Ghazaly","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.etap.2015.09.006_bib0075","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-3565(24)29210-7","article-title":"Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappa B, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats","volume":"299","author":"Fitzpatrick","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.etap.2015.09.006_bib0080","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1023\/A:1018807524075","article-title":"Sodium butyrate-induced liver-type alkaline phosphatase activity in a small intestinal epithelial cell line, IEC6","volume":"43","author":"Fukushima","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.etap.2015.09.006_bib0085","first-page":"622","article-title":"The effect of ethanolic extract of propolis on radiation-induced mucositis in rats","volume":"31","author":"Ghassemi","year":"2010","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.etap.2015.09.006_bib0090","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.radonc.2013.10.030","article-title":"MiR-210: a potential therapeutic target against radiation-induced enteropathy","volume":"111","author":"Hamama","year":"2014","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.etap.2015.09.006_bib0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/SPC.0b013e3281108014","article-title":"Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management","volume":"1","author":"Hauer-Jensen","year":"2007","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"10.1016\/j.etap.2015.09.006_bib0100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid antioxidants: chemistry, metabolism and structure activity relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.etap.2015.09.006_bib0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10620-009-0780-x","article-title":"Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways","volume":"55","author":"Hepgul","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.etap.2015.09.006_bib0110","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/jn\/126.10.2519","article-title":"Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats","volume":"126","author":"Howarth","year":"1996","journal-title":"J. Nutr."},{"key":"10.1016\/j.etap.2015.09.006_bib0115","doi-asserted-by":"crossref","first-page":"19618","DOI":"10.3390\/ijms141019618","article-title":"A Combination of pre- and post-exposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage","volume":"14","author":"Ito","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.etap.2015.09.006_bib0120","first-page":"332","article-title":"The effect of whole-body radiation on blood levels of gastrointestinal peptides in the rat","volume":"1","author":"Katanyutanon","year":"2008","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.etap.2015.09.006_bib0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cden.2007.10.002","article-title":"Management of oral mucositis in patients who have cancer","volume":"52","author":"Lalla","year":"2008","journal-title":"Dent. Clin. N. Am."},{"key":"10.1016\/j.etap.2015.09.006_bib0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bbrc.2005.09.071","article-title":"Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the regulation of TLR4 expression","volume":"337","author":"Lee","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2015.09.006_bib0135","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ijrobp.2003.09.039","article-title":"Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NFkappaB inhibitor","volume":"58","author":"Linard","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.etap.2015.09.006_bib0140","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.oraloncology.2006.04.011","article-title":"Nuclear factor kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy","volume":"43","author":"Logan","year":"2007","journal-title":"Oral Oncol."},{"key":"10.1016\/j.etap.2015.09.006_bib0145","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0360-3016(03)00781-8","article-title":"Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage","volume":"57","author":"Lutgens","year":"2003","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.etap.2015.09.006_bib0150","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijrobp.2004.02.052","article-title":"Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients","volume":"60","author":"Lutgens","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.etap.2015.09.006_bib0155","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1089\/dna.2006.25.684","article-title":"The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression","volume":"25","author":"Malo","year":"2006","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.etap.2015.09.006_bib0160","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/mnfr.201100105","article-title":"Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-\u03baB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells","volume":"55","author":"Mapesa","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.etap.2015.09.006_bib0165","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1124\/jpet.103.060673","article-title":"Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappa B transcription factors","volume":"308","author":"Marquez","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.etap.2015.09.006_bib0170","first-page":"1196","article-title":"Dose-dependent profile of ethanolic extracts of Iranian propolis on radiation-induced mucositis in rats","volume":"32","author":"Motallebnejad","year":"2011","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.etap.2015.09.006_bib0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5005\/jp-journals-10024-1479","article-title":"Evaluation of protective effect of propolis on parotid salivary glands in gamma-irradiated rats","volume":"15","author":"Motallebnejad","year":"2014","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.etap.2015.09.006_bib0180","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.1440-1681.2000.03380.x","article-title":"Changes in absorptive function of rat intestine injured by methotrexate","volume":"27","author":"Naruhashi","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.etap.2015.09.006_bib0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1748-717X-5-22","article-title":"Pro-inflammatory cytokines play a key role in the development of radiotherapy induced gastrointestinal mucositis","volume":"5","author":"Ong","year":"2010","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.etap.2015.09.006_bib0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0167-8140(90)90024-Q","article-title":"Effect of radiation on glucose absorption in the mouse jejunum in vivo","volume":"18","author":"Overgaard","year":"1990","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.etap.2015.09.006_bib0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005176-199307000-00007","article-title":"Influence of orally administered epidermal growth factor on normal and damaged intestinal mucosa in rats","volume":"17","author":"Petschow","year":"1993","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.etap.2015.09.006_bib0200","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tox.2004.12.009","article-title":"Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes","volume":"209","author":"Prasad","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2015.09.006_bib0205","first-page":"23","article-title":"Gastrointestinal peptide signalling in health and disease","volume":"587","author":"Rozengurt","year":"2002","journal-title":"Eur. J. Surg. Suppl."},{"key":"10.1016\/j.etap.2015.09.006_bib0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0367-326X(02)00187-9","article-title":"Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galengin","volume":"73","author":"Russo","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.etap.2015.09.006_bib0215","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4161\/cbt.5.6.2659","article-title":"Oral ingestion of Streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats","volume":"5","author":"Tooley","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.etap.2015.09.006_bib0220","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/gut.2007.128868","article-title":"Role of alkaline phosphatase in colitis in man and rats","volume":"58","author":"Tuin","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.etap.2015.09.006_bib0225","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursors in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915300855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915300855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T01:45:12Z","timestamp":1748655912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668915300855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1382668915300855"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2015.09.006","relation":{},"ISSN":["1382-6689"],"issn-type":[{"type":"print","value":"1382-6689"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2015.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}