{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:36:13Z","timestamp":1769877373778,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81374008"],"award-info":[{"award-number":["81374008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2013022002"],"award-info":[{"award-number":["2013022002"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Quanmin Oral Graduate Sci-tech Innovation Foundation, the President Fund of Liaoning Medical University","award":["QM2014002"],"award-info":[{"award-number":["QM2014002"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.etap.2015.09.007","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T06:01:01Z","timestamp":1442383261000},"page":"764-773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation"],"prefix":"10.1016","volume":"40","author":[{"given":"Meng","family":"Mei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meili","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonghua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghui","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2015.09.007_bib0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2011.10.037","article-title":"Activation of mitochondrial mu-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion","volume":"415","author":"Chen","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2015.09.007_bib0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yexcr.2009.07.025","article-title":"Up-regulation of calcium-dependent proteolysis in human myoblasts under acute oxidative stress","volume":"316","author":"Dargelos","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.etap.2015.09.007_bib0015","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3892\/mmr.2015.3400","article-title":"Effect of astragaloside IV against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial ATP-sensitive potassium channels","volume":"12","author":"Guan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.etap.2015.09.007_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1248\/cpb.c13-00556","article-title":"Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K\/Akt pathway","volume":"62","author":"Jia","year":"2014","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.etap.2015.09.007_bib0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11010-011-1022-z","article-title":"Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy","volume":"359","author":"Jing","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2015.09.007_bib0030","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1007\/s11033-014-3560-4","article-title":"Protective effect of calpain inhibitor N-acetyl-l-leucyl-l-leucyl-l-norleucinal on acute alcohol consumption related cardiomyopathy","volume":"41","author":"Kartkaya","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.etap.2015.09.007_bib0035","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.etap.2015.09.007_bib0040","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1440-1681.2009.05243.x","article-title":"Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure","volume":"36","author":"Li","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.etap.2015.09.007_bib0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-013-1686-7","article-title":"Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol","volume":"381","author":"Lu","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2015.09.007_bib0050","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ptr.5297","article-title":"Astragaloside IV attenuates injury caused by myocardial ischemia\/reperfusion in rats via regulation of toll-like receptor 4\/nuclear factor-kappaB signaling pathway","volume":"29","author":"Lu","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2015.09.007_bib0055","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.etap.2015.03.014","article-title":"Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-alpha\/PGC-1alpha signaling mediated energy biosynthesis","volume":"39","author":"Luan","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2015.09.007_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2015.06.005","article-title":"PD150606 protects against ischemia\/reperfusion injury by preventing mu-calpain-induced mitochondrial apoptosis","author":"Luo","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.etap.2015.09.007_bib0065","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1113\/jphysiol.2014.286518","article-title":"Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy","volume":"593","author":"Min","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.etap.2015.09.007_bib0070","first-page":"65","article-title":"Role of calpain in apoptosis","volume":"13","author":"Momeni","year":"2011","journal-title":"Cell J."},{"key":"10.1016\/j.etap.2015.09.007_bib0075","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/cdd.2008.123","article-title":"An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death","volume":"15","author":"Norberg","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.etap.2015.09.007_bib0080","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1089\/ars.2011.3973","article-title":"Mechanistic links between oxidative stress and disuse muscle atrophy","volume":"15","author":"Powers","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.etap.2015.09.007_bib0085","doi-asserted-by":"crossref","first-page":"E31","DOI":"10.1152\/ajpendo.00609.2011","article-title":"Mitochondrial signaling contributes to disuse muscle atrophy","volume":"303","author":"Powers","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.etap.2015.09.007_bib0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BJ20061903","article-title":"NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation","volume":"406","author":"Serrander","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.etap.2015.09.007_bib0095","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.24999","article-title":"Nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat","author":"Sheng","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.etap.2015.09.007_bib0100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/cvr\/cvs163","article-title":"Calpains, mitochondria, and apoptosis","volume":"96","author":"Smith","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.etap.2015.09.007_bib0105","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/FJC.0b013e3181d9f5d4","article-title":"Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium","volume":"55","author":"Suryakumar","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.etap.2015.09.007_bib0110","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.2337\/diabetes.53.2007.S12","article-title":"Structure, activation, and biology of calpain","volume":"53","author":"Suzuki","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.etap.2015.09.007_bib0115","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1152\/japplphysiol.01383.2011","article-title":"Early apoptosis in different models of cardiac hypertrophy induced by high renin-angiotensin system activity involves CaMKII","volume":"112","author":"Velez Rueda","year":"2012","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.etap.2015.09.007_bib0120","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fct.2012.12.022","article-title":"Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes","volume":"53","author":"Xiao","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2015.09.007_bib0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1749-8090-6-54","article-title":"VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation","volume":"6","author":"Xu","year":"2011","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.etap.2015.09.007_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2013.10.017","article-title":"Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4\/NF-small ka, CyrillicB signaling pathway in isoproterenol-induced myocardial hypertrophy","author":"Yang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etap.2015.09.007_bib0135","doi-asserted-by":"crossref","first-page":"e0118759","DOI":"10.1371\/journal.pone.0118759","article-title":"Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-kappaB\/PGC-1alpha signaling mediated energy biosynthesis","volume":"10","author":"Zhang","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.etap.2015.09.007_bib0140","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bbadis.2015.01.019","article-title":"Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia\/reoxygenation","volume":"1852","author":"Zheng","year":"2015","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915300867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915300867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T16:24:16Z","timestamp":1567182256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668915300867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1382668915300867"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2015.09.007","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2015.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}