{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:51:00Z","timestamp":1778215860444,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Liaoning science and technology research projects","award":["2013225086"],"award-info":[{"award-number":["2013225086"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.etap.2015.11.001","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T21:20:48Z","timestamp":1447363248000},"page":"13-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction"],"prefix":"10.1016","volume":"43","author":[{"given":"Yanhua","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongda","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongnan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2015.11.001_bib0005","series-title":"Pharmacy Dictionary","first-page":"340","author":"Chinese Pharmaceutical Association","year":"2006"},{"key":"10.1016\/j.etap.2015.11.001_bib0185","first-page":"168","volume":"vol. 1","author":"Chinese Pharmacopoeia Commission","year":"2010"},{"key":"10.1016\/j.etap.2015.11.001_bib0010","doi-asserted-by":"crossref","first-page":"8975","DOI":"10.1073\/pnas.0308484101","article-title":"Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A\/STK15 depletion","volume":"101","author":"Du","year":"2004","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.etap.2015.11.001_bib0015","first-page":"52","volume":"vol. 1","author":"Duke","year":"1985"},{"key":"10.1016\/j.etap.2015.11.001_bib0020","first-page":"363","volume":"vol. 2","author":"Duke","year":"1985"},{"issue":"1","key":"10.1016\/j.etap.2015.11.001_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/1541-7786.MCR-06-0208","article-title":"Roles of aurora kinases in mitosis and tumorigenesis","volume":"5","author":"Fu","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.etap.2015.11.001_bib0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tcb.2005.03.004","article-title":"Aurora kinases, aneuploidy and cancer, a coincidence or a real link?","volume":"15","author":"Giet","year":"2005","journal-title":"Trends Cell Biol."},{"issue":"15","key":"10.1016\/j.etap.2015.11.001_bib0040","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1158\/0008-5472.CAN-05-3353","article-title":"The aurora kinase inhibitor vx-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function","volume":"66","author":"Gizatullin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2015.11.001_bib0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0378-8741(00)00341-X","article-title":"Plants used against cancer-an extension of the work of Jonathan Hartwell","volume":"73","author":"Graham","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.etap.2015.11.001_bib0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1517\/17460441.2011.555395","article-title":"Update on aurora kinase targeted therapeutics in oncology","volume":"6","author":"Green","year":"2011","journal-title":"Expert Opin. Drug Discov."},{"issue":"4","key":"10.1016\/j.etap.2015.11.001_bib0060","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12253-012-9534-8","article-title":"Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy","volume":"18","author":"Hegyi","year":"2012","journal-title":"Pathol. Oncol. Res."},{"issue":"3","key":"10.1016\/j.etap.2015.11.001_bib0065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0092-8674(00)00034-9","article-title":"Mitotic phosphorylation of histone h3 is governed by ipl1\/aurora kinase and glc7\/pp1 phosphatase in budding yeast and nematodes","volume":"102","author":"Hsu","year":"2000","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.etap.2015.11.001_bib0070","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood-2007-07-099325","article-title":"Aurora kinase inhibitory VX-680 increases Bax\/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia","volume":"111","author":"Huang","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.etap.2015.11.001_bib0075","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jep.2013.07.030","article-title":"Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma","volume":"149","author":"Hu","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.etap.2015.11.001_bib0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.200208092","article-title":"The small molecule hesperadin reveals a role for Aurora-B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint","volume":"161","author":"Hauf","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.etap.2015.11.001_bib0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12185-009-0462-7","article-title":"P53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells","volume":"91","author":"Ikezoe","year":"2010","journal-title":"Int. J. Hematol."},{"issue":"4","key":"10.1016\/j.etap.2015.11.001_bib0090","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.bbrc.2005.08.235","article-title":"Survivin inhibits anti-growth effect of p53 activated by aurora B","volume":"336","author":"Jung","year":"2005","journal-title":"Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.etap.2015.11.001_bib0095","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12253-012-9534-8","article-title":"Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy","volume":"18","author":"Katalin","year":"2012","journal-title":"Pathol. Oncol. Res."},{"issue":"10","key":"10.1016\/j.etap.2015.11.001_bib0100","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.bbagrm.2010.09.004","article-title":"Aurora kinase inhibitors as anticancer molecules","volume":"1799","author":"Katayama","year":"2010","journal-title":"Biochim. Biophys. Acta (BBA)-Gene Regul. Mechan."},{"issue":"22","key":"10.1016\/j.etap.2015.11.001_bib0105","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1016\/j.febslet.2011.10.022","article-title":"Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway","volume":"585","author":"Kim","year":"2011","journal-title":"FEBS Lett."},{"issue":"7","key":"10.1016\/j.etap.2015.11.001_bib0110","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/blood-2008-01-128611","article-title":"Concomitant inhibition of mdm2-p53 interaction and aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia","volume":"112","author":"Kojima","year":"2008","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.etap.2015.11.001_bib0115","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s10529-013-1164-z","article-title":"S39, a novel Aurora B kinase inhibitor, shows potent antineoplastic activity in human Hela cervical cancer cell line","volume":"35","author":"Li","year":"2013","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.etap.2015.11.001_bib0120","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/leu.2010.15","article-title":"Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias","volume":"24","author":"Moore","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.etap.2015.11.001_bib0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ctrv.2007.09.005","article-title":"Aurora kinases as targets for cancer therapy","volume":"34","author":"Mountzios","year":"2008","journal-title":"Cancer Treat. Rev."},{"issue":"7","key":"10.1016\/j.etap.2015.11.001_bib0130","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.oraloncology.2007.08.010","article-title":"Aurora kinase small molecule inhibitor destroys mitotic spindle, suppresses cell growth, and induces apoptosis in oral squamous cancer cells","volume":"44","author":"Pan","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.etap.2015.11.001_bib0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jpba.2011.08.033","article-title":"Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry","volume":"57","author":"Qiao","year":"2012","journal-title":"J. Pharmaceut. Biomed."},{"issue":"5","key":"10.1016\/j.etap.2015.11.001_bib0140","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.yexcr.2011.12.014","article-title":"The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis","volume":"318","author":"Salmela","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.etap.2015.11.001_bib0145","doi-asserted-by":"crossref","first-page":"669","DOI":"10.5012\/bkcs.2008.29.3.669","article-title":"A new sterol from whole plants of Eriocaulon sieboldianum","volume":"29","author":"Song","year":"2008","journal-title":"B Kor. Chem. Soc."},{"issue":"1","key":"10.1016\/j.etap.2015.11.001_bib0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbcan.2008.07.003","article-title":"The Aurora kinase family in cell division and cancer","volume":"1786","author":"Vader","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA)-Rev. Cancer"},{"issue":"1","key":"10.1016\/j.etap.2015.11.001_bib0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0092-8674(00)80718-7","article-title":"Phosphorylation of histone H3 is required for proper chromosome condensation and segregation","volume":"97","author":"Wei","year":"1999","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.etap.2015.11.001_bib0165","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejps.2012.03.002","article-title":"The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells","volume":"46","author":"Xie","year":"2012","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.etap.2015.11.001_bib0170","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.foodchem.2013.01.018","article-title":"Flavonoids from the capitula of Eriocaulon austral","volume":"139","author":"Xu","year":"2013","journal-title":"Food Chem."},{"issue":"6","key":"10.1016\/j.etap.2015.11.001_bib0175","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2007-02-073700","article-title":"AZD1152, a novel and selective Aurora-B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo","volume":"110","author":"Yang","year":"2007","journal-title":"Blood"},{"issue":"5\u20136","key":"10.1016\/j.etap.2015.11.001_bib0180","first-page":"241","article-title":"Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines","volume":"20","author":"Zekri","year":"2012","journal-title":"Oncol. Res. Feat. Preclin. Clin. Cancer Therapeu."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915301150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668915301150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T13:46:18Z","timestamp":1567345578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668915301150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":34,"alternative-id":["S1382668915301150"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2015.11.001","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2015.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}